Generic Name
Brexpiprazole
Brand Name
Rexulti
Class
Atypical Neuroleptic, Serotonin-Dopamine Modulators (SDAM)
Proposed Mechanism(s) of Action
The efficacy of brexpiprazole may be mediated through a combination of partial agonist activity as serotonin 5-HT1A and dopamine D2 receptors, and antagonist activity at serotonin 5-HT2A receptors.
Indication
Schizophrenia, adjunctive treatment of major depressive disorder
Off Label Use
No common offlabel use
Side Effects
Serious
Increased risk of death in elderly people with dementia-related psychosis, CVA among elderly patients, hyperglycemia, low white blood cell count, orthostatic hypotension, seizures.
Common
Headache, weight gain, somnolence, dyspepsia, constipation, fatigue, dizziness, anxiety, restlessness, increased appetite.
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Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Additional Information
CenterWatch: https://www.centerwatch.com/drug-information/fda-approved-drugs/drug/100084/rexulti-brexpiprazole.
Drug Molecule Images: http://www.worldofmolecules.com/drugs/.
Free Drug Online and PDA Software: www.epocrates.com.
Free Drug Online and PDA Software.
Gene-Based Estimate of Drug interactions: http://mhc.daytondcs.com: 8080/cgi bin/ddiD4?ver=4&task=getDrugList.
Medscape Psychiatry.
Pill Identification.: http://www.drugs.com/pill_identification.html.
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Gonzalez, E.A. (2018). Brexipiprazole. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_9262
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DOI: https://doi.org/10.1007/978-3-319-57111-9_9262
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Publisher Name: Springer, Cham
Print ISBN: 978-3-319-57110-2
Online ISBN: 978-3-319-57111-9
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