Generic Name
Paroxetine
Brand Name
Paxil, Paxil XR, Paxil CR, Brisdelle, and Pexeva
Class
Antidepressants, selective serotonin reuptake inhibitor
Proposed Mechanism(s) of Action
Increases serotonin by blocking the serotonin reuptake pump. Theoretically inhibits muscarinic recycles and blocks nitric oxide synthase Cyp450 260, 2C19, and 3A4 enzymes
Indication
Major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, post-traumatic stress disorder, generalized anxiety disorder, premenstrual dysphoric disorder, and menopausal vasomotor symptoms
Off-Label Use
Stuttering, vasovagal syncope, and diabetic neuropathy
Side Effects
Serious
Seizures, mania, and suicidal ideation (rare)
Common
Sexual dysfunction, decreased appetite, nausea, dry mouth, insomnia, tremors, agitation, sweating, bruising, bleeding, and hyponatremia
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References and Readings
Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug interaction effects. http://www.drugs.com/drug_interactions.html
Drug molecule images. http://www.worldofmolecules.com/drugs/
Free drug online and PDA software. www.epocrates.com
Free Drug Online and PDA Software. www.medscape.com
Gene-based estimate of drug interactions. http://mhc.daytondcs.com:8080/cgi bin/ddiD4?ver=4&task=getDrugList
Pill identification. http://www.drugs.com/pill_identification.html
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Courtney, J.C., Akins, C., Gonzalez, E.A. (2018). Paroxetine. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1688
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1688
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Online ISBN: 978-3-319-57111-9
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