Abstract
Neuroimaging in cerebral palsy, although not a prerequisite for diagnosis, provides vital insights in elucidating the etiopathogenesis and has widespread implications in treatment, prognosis, and planning early interventions to curtail complications. Neuroimaging is abnormal in a majority of children with cerebral palsy. Magnetic resonance imaging, due to its superior soft tissue differentiation, multiplanar capabilities, and prospect for functional imaging, is uniquely qualified for assessment of fetal and postnatal brain. Cranial ultrasound and computed tomography, although inferior in soft tissue resolution, have a potential role in emergent situations. Hypoxic-ischemic encephalopathy is one of the commonly identified causes of cerebral palsy with other etiologies being congenital infections of central nervous system such as Cytomegalovirus (CMV) and toxoplasmosis and congenital malformations.
References
Aicardi J (2005) Aicardi syndrome. Brain Dev 27(3):164–171
Anderson JL, Levy PT, Leonard KB et al (2014) Congenital lymphocytic choriomeningitis virus: when to consider the diagnosis. J Child Neurol 29(6):837–842
Ashwal S, Russman BS, Blasco BA et al (2004) Practice parameter: diagnostic assessment of the child with cerebral palsy. Neurology 62:851–863
Averill LW, Kandula VV, Akyol Y, Epelman M (2015) Fetal brain magnetic resonance imaging findings in congenital cytomegalovirus infection with postnatal imaging correlation. Semin Ultrasound CT MR 36:476–486
Bahi-Buisson N et al (2013) New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum. Brain 136(Pt 1):223–244
Barkovich AJ (1992) MR and CT evaluation of profound neonatal and infantile asphyxia. Am J Neuroradiol 13:959–972
Barkovich AJ (2012) Pediatric neuroimaging, 5th edn. Lippincott Williams & Wilkins, Philadelphia
Barkovich AJ, Kjos BO (1992) Schizencephaly: correlation of clinical findings with MR characteristics. Am J Neuroradiol 13:85–94
Barkovich AJ, Sargent SK (1995) Profound asphyxia in the premature infant: imaging findings. AJNR Am J Neuroradiol 16:1837–1846
Barkovich AJ, Koch TK, Carrol CL (1991) The spectrum of lissencephaly: report of ten cases analyzed by magnetic resonance imaging. Ann Neurol 30:139–146
Barkovich AJ et al (2012) A developmental and genetic classification for malformations of cortical development: update 2012. Brain 135(Pt 5):1348–1369
Basu AP (2014) Early intervention after perinatal stroke: opportunities and challenges. Dev Med Child Neurol 56(6):516–521. https://doi.org/10.1111/dmcn.12407
Bax M, Goldstein M, Rosenbaum P, Leviton A, Paneth N, Dan B, Jacobsson B, Damiano D, Executive Committee for the Definition of Cerebral Palsy (2005) Proposed definition and classification of cerebral palsy, April 2005. Dev Med Child Neurol 47(8):571–576
Bekiesinska-Figatowska M, Walecki J (2001) MRI of the hypophysis in a patient with the 18q- syndrome. Neuroradiology 43:875–876
Boltshauser E, Isler W (1977) Joubert syndrome: episodic hyperpnea, abnormal eye movements, retardation and ataxia, associated with dysplasia of the cerebellar vermis. Neuropadiatrie 8:57–66
Bonthius DJ (2012) Lymphocytic choriomeningitis virus: an under-recognized cause of neurologic disease in the fetus, child and adult. Semin Pediatr Neurol 19:89–95
Bonthius DJ, Nichols B, Harb H, Mahoney J, Karacay B (2007a) Lymphocytic choriomeningitis virus infection of the developing brain: critical role of host age. Ann Neurol 62:356–374
Bonthius DJ, Wright R, Tseng B et al (2007b) Congenital lymphocytic choriomeningitis virus infection: spectrum of disease. Ann Neurol 62:347–355
Bouyssi-Kobar M, du Plessis AJ, Robertson RL, Limperopoulos C (2015) Fetal magnetic resonance imaging: exposure times and functional outcomes at preschool age. Pediatr Radiol 45:1823–1830
Boylan G, Young K, Panerai R, Rennie J, Evans D (2000) Dynamic cerebral autoregulation in sick newborn infants. Pediatr Res 48:12–17
Breedveld G, de Coo IF, Lequin MH et al (2006) Novel mutations in three families confirm a major role of COL4A1 in hereditary porencephaly. J Med Genet 43:490–495
Brown LY, Odent S, David V et al (2001) Holoprosencephaly due to mutation in. ZIC2: alanine tract expansion mutations may be caused by parental somatic recombination. Hum Mol Genet 10:791–796
Cecchetto G, Milanese L, Giordano R, Viero A, Suma V, Manara R (2013) Looking at the missing brain: hydranencephaly case series and literature review. Pediatr Neurol 48(2):152–158. https://doi.org/10.1016/j.pediatrneurol.2012.10.009
Cemeroglu AP et al (2015) Spectrum of clinical presentations and endocrinological findings of patients with septo-optic dysplasia: a retrospective study. J Pediatr Endocrinol Metab 28(9–10):1057–1063
Chao CP, Zaleski CG, Patton AC (2006) Neonatal hypoxic-ischemic encephalopathy: multimodality imaging findings. Radiographics 26(Suppl 1):S159–S172
Chih-Ping Chen, Shu-Chin Chien (2010) Prenatal sonographic features of Miller-Dieker syndrome. J Med Ultrasound 18(4):147–152
Colombani M, Chouchane M, Pitelet G, Morales L, Callier P, Pinard JP, Lion-François L, Thauvin-Robinet C, Mugneret F, Huet F, Guibaud L, Faivre L (2006) A new case of megalencephaly and perisylvian polymicrogyria with post-axial polydactyly and hydrocephalus: MPPH syndrome. Eur J Med Genet 49(6):466–471
Colugnati FA, Staras SA, Dollard SC, Cannon MJ (2007) Incidence of cytomegalovirus infection among the general population and pregnant women in the United States. BMC Infect Dis 7:71
Curry CJ, Lammer EJ, Nelson V, Shaw GM (2005) Schizencephaly: heterogeneous etiologies in a population of 4 million California births. Am J Med Genet A 137(2):181–189
de Grouchy J, Royer P, Salmon C, Lamy M (1964) Délétion partielle des bras longs du chromosome 18. Pathol Biol 12:579–582
de Vries LS, Groenendaal F (2010) Patterns of neonatal hypoxic-ischaemic brain injury. Neuroradiology 52(6):555–566. https://doi.org/10.1007/s00234-010-0674-9
Del Toro J, Louis PT, Goddard-Finegold J (1991) Cerebrovascular regulation and neonatal brain injury. Pediatr Neurol 7:3–12
Delaine M, Weingertner AS, Nougairede A et al (2017) Microcephaly caused by lymphocytic choriomeningitis virus. Emerg Infect Dis 23:1548–1550
Démurger F, Pasquier L, Dubourg C, Dupé V, Gicquel I, Evain C, Ratié L, Jaillard S, Beri M, Leheup B, Lespinasse J, Martin-Coignard D, Mercier S, Quelin C, Loget P, Marcorelles P, Laquerrière A, Bendavid C, Odent S, David V (2013) Array-CGH analysis suggests genetic heterogeneity in rhombencephalosynapsis. Mol Syndromol 4(6):267–272. https://doi.org/10.1159/000353878
Diebler C, Dusser A, Dulac O (1985) Congenital toxoplasmosis. Clinical and neuroradiological evaluation of the cerebral lesions. Neuroradiology 27:125–130
Dobyns W, Barkovich A (1999) Microcephaly with simplified gyral pattern (oligogyric microcephaly) and microlissencephaly. Neuropediatrics 30:105–106
Doneda C, Parazzini C, Righini A et al (2010) Early cerebral lesions in cytomegalovirus infection: prenatal MR imaging. Radiology 255(2):613–621
Elliott R, Harter DH (2008) Rhombencephalosynapsis associated with autosomal dominant polycystic kidney disease Type 1. J Neurosurg Pediatr 2:435–437
Fink KR, Thapa MM, Ishak GE, Pruthi S (2010) Neuroimaging of pediatric central nervous system cytomegalovirus infection. Radiographics 30:1779–1796
Garne E, Dolk H, Krägeloh-Mann I, Holst Ravn S, Cans C, SCPE Collaborative Group (2008) Cerebral palsy and congenital malformations. Eur J Paediatr Neurol 12(2):82–88. Epub 2007 Sep 19
Greisen G (1992) Ischemia of the preterm brain. Biol Neonate 62:243–247
Hedlund G, Bale JF, Barkovich AJ (2012) Infections of the developing and mature nervous system. In: Barkovich AJ, Raybaud C (eds) Pediatric neuroimaging, 5th edn. Lippincott Williams and Wilkins, Philadelphia, pp 954–1050
Himmelmann K, Horber V, De La Cruz J, Horridge K, Mejaski-Bosnjak V, Hollody K, Krägeloh-Mann I, SCPE Working Group (2017) MRI classification system (MRICS) for children with cerebral palsy: development, reliability, and recommendations. Dev Med Child Neurol 59:57–64. https://doi.org/10.1111/dmcn.13166
Hopkins B, Sutton VR, Lewis RA, Van den Veyver I, Clark G (2008) Neuroimaging aspects of Aicardi syndrome. Am J Med Genet A 146A(22):2871–2878. https://doi.org/10.1002/ajmg.a.32537
Inder T, Anderson N, Spencer C, Wells S, Volpe J (2003) White matter injury in the premature infant: a comparison between serial cranial sonographic and MR findings at term. Am J Neuroradiol 24:805–809
Jeong WK, Joo BE, Seo JH et al (2015) Mesial temporal lobe epilepsy in toxoplasmosis: a case report. J Epilepsy Res 5:25–28
Joubert M, Eisenring JJ, Robb JP et al (1969) Familial agenesis of the cerebellar vermis. A syndrome of episodic hyperpnea, abnormal eye movements, ataxia, and retardation. Neurology 19:813–825
Kadri H, Mawla AA, Kazah J (2006) The incidence, timing, and predisposing factors of germinal matrix and intraventricular hemorrhage (GMH/IVH) in preterm neonates. Childs Nerv Syst 22(9):1086–1090
Kelberman D, Dattani MT (2007) Genetics of septo-optic dysplasia. Pituitary 10(4):393–407
Kobayashi Y, Kawashima H, Magara S, Akasaka N, Tohyama J (2015) Gómez-López-Hernández syndrome in a Japanese patient: a case report. Brain Dev 37(3):356–358. https://doi.org/10.1016/j.braindev.2014.05.002.
Korzeniewski SJ, Birbeck G, DeLano MC, Potchen MJ, Paneth N (2008) A systematic review of neuroimaging for cerebral palsy. J Child Neurol 23:216–227
Krägeloh-Mann I, Horber V (2007) The role of MR imaging in elucidating pathogenesis of cerebral palsy – a systematic review. Dev Med Child Neurol 47:144–151
Lammens M, Heil J, Gabree FJ, van Engelen B, van den Heuvel L, Weemaes C (2003) Nijmegen breakage syndrome: a neuropathological study. Neuropediatrics 34:189–193
Lancaster JL, Cody JD, Andrews T et al (2005) Myelination in children with partial deletions of chromosome 18q. Am J Neuroradiol 26:447–454
Lanni G, Catalucci A, Conti L, Di Sibio A, Paonessa A, Gallucci M (2011) Pediatric stroke: clinical findings and radiological approach. Stroke Res Treat 2011:172168, 11 pages,. https://doi.org/10.4061/2011/172168
Li AM, Chau V, Poskitt KJ et al (2009) White matter injury in term newborns with neonatal encephalopathy. Pediatr Res 65:85–89
Limitations of Cranial Ultrasonography and Recommendations for MRI. In: Neonatal cranial ultrasonography (2007). Springer, Berlin/Heidelberg
Loevner LA, Shapiro RM, Grossman RI et al (1996) White matter changes associated with deletions of the long arm of chromosome 18 (18q- syndrome): a dysmyelinating disorder? Am J Neuroradiol 17:1843–1848
Louie CM, Gleeson JG (2005) Genetic basis of Joubert syndrome and related disorders of cerebellar development. Hum Mol Genet 14(Suppl 2):R235–R242
Lyons K, Cassady C, Jones J et al (2015) Current role of fetal magnetic resonance imaging in neurologic anomalies. Semin Ultrasound CT MR 36:298–309
Machado V, Pimentel S, Pinto F, Nona J (2015) Perinatal ischemic stroke: a five-year retrospective study in a level-III maternity. Einstein Sao Paulo 13(1):65–71. https://doi.org/10.1590/S1679-45082015AO3056. English, Portuguese
MacLennan AH, Thompson SC, Gecz J (2015) Cerebral palsy: causes, pathways, and the role of genetic variants. Am J Obstet Gynecol 213(6):779–788. https://doi.org/10.1016/j.ajog.2015.05.034
Malinger G, Werner H, Leonel JCR et al (2011) Prenatal brain imaging in congenital toxoplasmosis. Prenat Diagn 31:881–886
Malm G, Engman ML (2007) Congenital cytomegalovirus infections. Semin Fetal Neonatal Med 12:154–159
Manganaro L, Bernardo S, Antonelli A et al (2017) Fetal MRI of the central nervous system: state-of-the-art. Eur J Radiol 93:273–283
Maria BL, Hoang KB, Tusa RJ et al (1997) “Joubert syndrome” revisited: key ocular motor signs with magnetic resonance imaging correlation. J Child Neurol 12:423–430
Meuwissen ME, de Vries LS, Verbeek HA, Lequin MH, Govaert PP, Schot R, Cowan FM, Hennekam R, Rizzu P, Verheijen FW, Wessels MW, Mancini GM (2011) Sporadic COL4A1 mutations with extensive prenatal porencephaly resembling hydranencephaly. Neurology 76:844–846. https://doi.org/10.1212/WNL.0b013e31820e7751
Miller G, Mowrey PN, Hopper KD, Frankel CA, Ladda RL (1990) Neurologic manifestations in 18q2 syndrome. Am J Med Genet 37:128–132
Miller SP, Shevell MI, Patenaude Y, Poulin C, O’Gorman AM (2000) Septo-optic dysplasia plus: a spectrum of malformations of cortical development. Neurology 54(8):1701–1703
Mirzaa G. MPPH syndrome. 2016 Nov 17. In: Adam MP, Ardinger HH, Pagon RA, et al. (ed) GeneReviews® [Internet]. University of Washington, Seattle, Seattle, pp 1993–2017
Mirzaa G, Dodge NN, Glass I, Day C, Gripp K, Nicholson L, Straub V, Voit T, Dobyns WB (2004) Megalencephaly and perisylvian polymicrogyria with postaxial polydactyly and hydrocephalus: a rare brain malformation syndrome associated with mental retardation and seizures. Neuropediatrics 35(6):353–359
Nelson KB (2007) Perinatal ischemic stroke. Stroke 38(2 Suppl):742–745
Oguni H, Sugama M, Osawa M (2008) Symptomatic parietooccipital epilepsy as sequela of perinatal asphyxia. Pediatr Neurol 38:345–352
Okereafor A, Allsop JM, Counsell SJ et al (2008) Patterns of brain injury in neonates exposed to perinatal sentinel events. Pediatrics 121:906–914
Okumura A et al (2013) Lissencephaly with marked ventricular dilation, agenesis of corpus callosum, and cerebellar hypoplasia caused by TUBA1A mutation. Brain Dev 35(3):274–279
Oskoui M, Coutinho F, Dykeman J, Jetté N, Pringsheim T (2013) An update on the prevalence of cerebral palsy: a systematic review and meta-analysis. Dev Med Child Neurol 55(6):509–519. https://doi.org/10.1111/dmcn.12080. Epub 2013 Jan 24. Review. Erratum in: Dev Med Child Neurol. 2016 Mar;58(3):316
Parashari UC, Singh R, Yadav R, Aga P (2009) Changes in the globus pallidus in chronic kernicterus. J Pediatr Neurosci 4(2):117–119. https://doi.org/10.4103/1817-1745.57333
Parisi M, Glass I. Joubert syndrome. 2003 Jul 9 [Updated 2017 Jun 29]. In: Adam MP, Ardinger HH, Pagon RA, et al. (ed) GeneReviews® [Internet]. University of Washington, Seattle, Seattle, pp 1993–2017
Pasquier L, Marcorelles P, Loget P et al (2009) Rhombencephalosynapsis and related anomalies: a neuropathological study of 40 fetal cases. Acta Neuropathol 117:185–200
Patel S, Barkovich AJ (2002) Analysis and classification of cerebellar malformations. AJNR Am J Neuroradiol 23(7):1074–1087
Patel DV, Holfels EM, Vogel NP et al (1996) Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis. Radiology 199:433–440
Pavone P, Praticò AD, Vitaliti G, Ruggieri M, Rizzo R, Parano E, Pavone L, Pero G, Falsaperla R (2014) Hydranencephaly: cerebral spinal fluid instead of cerebral mantles. Ital J Pediatr 40:79. https://doi.org/10.1186/s13052-014-0079-1
Poduri A, Evrony GD, Cai X, Elhosary PC, Beroukhim R, Lehtinen MK, Hills LB, Heinzen EL, Hill A, Hill RS, Barry BJ, Bourgeois BF, Riviello JJ, Barkovich AJ, Black PM, Ligon KL, Walsh CA (2012) Somatic activation of AKT3 causes hemispheric developmental brain malformations. Neuron 74:41–48. https://doi.org/10.1016/j.neuron.2012.03.010
Poretti A, Boltshauser E, Loenneker T, Valente EM, Brancati F, Il’yasov K, Huisman TA (2007) Diffusion tensor imaging in Joubert syndrome. AJNR Am J Neuroradiol 28(10):1929–1933
Rakic P, Sidman R (1970) Histogenesis of cortical layers in human cerebellum, particularly the lamina dissecans. J Comp Neurol 139:473–500
Ribiero BG, Werner H, Lopes FPPL et al (2017) Central nervous system effects of intrauterine Zika virus infection: a pictorial review. Radiographics 37:1840–1850
Rossi AC, Prefumo C (2014) Additional value of fetal magnetic resonance imaging in the prenatal diagnosis of central nervous system anomalies: a systematic review of the literature. Ultrasound Obstet Gynecol 44:388–393
Safadi MAP, Berezin EN, Farhat CF, Carvalho ES (2003) Clinical presentation and follow up of children with congenital toxoplasmosis in Brazil. Braz J Infect Dis 7(5):325–331
Saraiva JM, Baraitser M (1992) Joubert syndrome: a review. Am J Med Genet 43:726–731
Satran D, Pierpont ME, Dobyns WB (1999) Cerebello-oculo-renal syndromes including Arima, Senior-Löken and COACH syndromes: more than just variants of Joubert syndrome. Am J Med Genet 86:459–469
Schulte DJ, Comer JA, Erickson BR et al (2006) Congenital lymphocytic choriomeningitis: an underdiagnosed cause of neonatal hydrocephalus. Pediatr Infect Dis J 25:560–562
Shapiro SM (2010) Chronic bilirubin encephalopathy: diagnosis and outcome. Semin Fetal Neonatal Med 15(3):157–163. https://doi.org/10.1016/j.siny.2009.12.004
Shetty J, Fraser J, Goudie D, Kirkpatrick M (2014) Aicardi syndrome in a 47 XXY male – a variable developmental phenotype? Eur J Paediatr Neurol 18(4):529–531. https://doi.org/10.1016/j.ejpn.2014.03.004. Epub 2014 Mar 12
Simon EM, Hevner RF, Pinter JD et al (2002) The middle interhemispheric variant of holoprosencephaly. AJNR Am J Neuroradiol 23:151–155
Steggerda SJ, Leijser LM, Wiggers-de Bruïne FT, van der Grond J, Walther FJ, van Wezel-Meijler G (2009) Cerebellar injury in preterm infants: incidence and findings on US and MR images. Radiology 252(1):190–199. https://doi.org/10.1148/radiol.2521081525
Strizek B, Jani JC, Mucyo E et al (2015) Safety of MR imaging at 1.5T in fetuses: a retrospective case-control study of birth weights and the effects of acoustic noise. Radiology 275:530–537
Surendrababu ARS, Kuruvilla KA, Jana AK (2006) Unusual pattern of calcification in congenital toxoplasmosis: the tram track sign. Pediatr Radiol 36:569
Takanashi J, Barkovich AJ, Clegg NJ, Delgado MR (2003) Middle interhemispheric variant of holoprosencephaly associated with diffuse polymicrogyria. AJNR Am J Neuroradiol 24(3):394–397
Toba S et al (2012) A unique role of dynein and nud family proteins in corticogenesis. Neuropathology 32(4):432–439
Van Doorn M, Rengerink KO, Newsum EA et al (2016) Added value of fetal MRI in fetuses with suspected brain abnormalities on neurosonography: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 29:2949–2961
Varon R, Demuth I, Chrzanowska KH. Nijmegen breakage syndrome. 1999 May 17 [Updated 2017 Feb 2]. In: Adam MP, Ardinger HH, Pagon RA, et al. (ed) GeneReviews® [Internet]. University of Washington, Seattle, Seattle, pp 1993–2017
Victoria T, Jaramillo D, Roberts TPL et al (2014) Fetal magnetic resonance imaging: jumping from 1.5 to 3 tesla (preliminary experience). Pediatr Radiol 44:376–386
Volpe JJ (2008a) Hypoxic-ischemic encephalopathy: neuropathology and pathogenesis. In: Volpe JJ (ed) Neurology of the newborn. Saunders-Elsevier, Philadelphia, pp 347–399
Volpe JJ (2008b) Intracranial hemorrhage: germinal matrix-intraventricular hemorrhage of the premature infant. In: Volpe JJ (ed) Neurology of the newborn, 5th edn. Saunders-Elsevier, Philadelphia, pp 517–588
Widjaja E, Blaser S, Raybaud C (2006) Diffusion tensor imaging of midline posterior fossa malformations. Pediatr Radiol 36(6):510–517
Wright R, Johnson D, Neumann M et al (1997) Congenital lymphocytic choriomeningitis virus syndrome: a disease that mimics congenital toxoplasmosis or cytomegalovirus infection. Pediatrics 100:1–6
Yoneda Y, Haginoya K, Kato M, Osaka H, Yokochi K, Arai H, Kakita A, Yamamoto T, Otsuki Y, Shimizu S, Wada T, Koyama N, Mino Y, Kondo N, Takahashi S, Hirabayashi S, Takanashi J, Okumura A, Kumagai T, Hirai S, Nabetani M, Saitoh S, Hattori A, Yamasaki M, Kumakura A, Sugo Y, Nishiyama K, Miyatake S, Tsurusaki Y, Doi H, Miyake N, Matsumoto N, Saitsu H (2013) Phenotypic spectrum of COL4A1 mutations: porencephaly to schizencephaly. Ann Neurol 73(1):48–57. https://doi.org/10.1002/ana.23736
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Nikam, R.M., Choudhary, A.K., Kandula, V., Averill, L. (2019). Neuroimaging Pathology in Cerebral Palsy. In: Miller, F., Bachrach, S., Lennon, N., O'Neil, M. (eds) Cerebral Palsy. Springer, Cham. https://doi.org/10.1007/978-3-319-50592-3_10-1
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