Synonyms
Cowden syndrome; Hamartomatous polyposis; Juvenile polyposis; Juvenile polyps; Peutz-Jeghers polyps; Peutz-Jeghers syndrome
Definition
Hamartomatous polyps are malformations of tissue elements indigenous to the gastrointestinal (GI) tract that protrude into the visceral lumen (Fenoglio-Preiser et al. 2008). They are polypoid lesions characterized by a variable admixture of epithelial and mesenchymal elements that recapitulate the composition of normal gut.
Hamartomatous polyps can be found in almost any GI segment, either solitary sporadic lesions or part of hereditary polyposis syndromes. In the latter, in rare cases, their appearance is not specific, but in most, the histological features together with thorough clinical background will allow a proper diagnosis. This is of important prognostic importance since different polyposis syndromes have additional extra-GI manifestations and different association with the development of malignancy.
Peutz-Jeghers (PJ) polypsare part...
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References and Further Reading
Calva, D., & Howe, J. (2008). Hamartomatous polyposis syndromes. The Surgical clinics of North America, 88(4), 779.
Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008). Polyposis and hereditary cancer syndromes. In J. McGouh & J. Pine (Eds.), Gastrointestinal pathology an atlas and text (pp. 704–724). Philadelphia: Lippincott Williams & Wilkins.
Hornick, J. L., & Odze, R. D. (2009). Polyps of the large intestine. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.
Kopacova, M., Tacheci, I., Rejchrt, S., & Bures, J. (2009). Peutz-jeghers syndrome: Diagnostic and therapeutic approach. World Journal of Gastroenterology, 15(43), 5397–5408.
Lauwers, G. Y., Carneiro, F., Graham, D. Y., Curado, M. P., Franceschi, S., Montgomery, E., Tatematsu, M., & Hattori, T. (2010). Gastric carcinoma. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. D. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 48–58). Lyon: IARC.
Offerhaus, G. J. A., & Howe, J. R. (2010). Juvenile polyposis. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. D. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 166–167). Lyon: IARC.
Yantiss, R. K., & Antoniolli, D. A. (2009). Polyps of the small intestine. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.
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Baldaia, H. (2017). Hamartomatous Polyps. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1629
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DOI: https://doi.org/10.1007/978-3-319-40560-5_1629
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