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Kanerva’s Occupational Dermatology pp 1–20Cite as

Drug Allergens

  • Living reference work entry
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  • 200 Accesses

Abstract

Many drugs from very different drug classes and categories have been reported to elicit allergic contact dermatitis by direct contact or airborne exposure.

Rarely, immediate-type reactions with urticaria or anaphylaxis have been observed.

Employees in the development, production, and maintenance in the pharmaceutical industry and workers in health care are typically affected.

Most drugs are haptens and therefore need to be or become reactive to be able to bind to protein to form a complete antigen.

Some prodrugs and intermediate substances in the synthetization process are highly reactive and more prone to be allergenic.

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References

  • Alomar A, Puig L, Vilaltella I (1987) Allergic contact dermatitis due to ranitidine. Contact Dermatitis 17:54–55

    Article  PubMed  CAS  Google Scholar 

  • Altomare GF, Capella GL, Veraldi S (1992) Occupational drug dermatitis. Clin Dermatol 10:141–147

    Article  PubMed  CAS  Google Scholar 

  • Ancona A (1985) Allergic contact dermatitis to nitrofurazone. Contact Dermatitis 13:35

    Article  PubMed  CAS  Google Scholar 

  • Arévalo A, Blancas R, Ancona A (1995) Occupational contact dermatitis from piroxicam. Am J Contact Dermat 6:113–114

    Article  Google Scholar 

  • Baeck M, Goossens AN (2009) Patients with airborne sensitization/contact dermatitis from budesonide-containing aerosols ‘by proxy’. Contact Dermatitis 61:1–8

    Article  PubMed  CAS  Google Scholar 

  • Barbaud A (2002) Occupational dermatitis in health care personnel. Rev Prat 52:1425–1432

    PubMed  Google Scholar 

  • Barbaud A, Trechot P, Bertrand O, Schmutz JL (1995) Occupational allergy to propacetamol. Lancet 346:902

    Article  PubMed  CAS  Google Scholar 

  • Barbaud A, Reichert-Penetrat S, Tréchot P, Cuny JF, Weber M, Schmutz JL (1997) Occupational contact dermatitis to propacetamol. Allergological and chemical investigations in two cases. Dermatology 195:329–331

    Article  PubMed  CAS  Google Scholar 

  • Barberá E, De La Cuadra J (1989) Occupational airborne allergic contact dermatitis from tylosin. Contact Dermatitis 20:308–309

    Article  PubMed  Google Scholar 

  • Barroga A, Romaguera C, Vilaplana J (1992) Contact dermatitis from avoparcin. Contact Dermatitis 27:115

    Article  Google Scholar 

  • Bause GS, Kugelman LC (1990) Contact anaphylactoid response to labetalol. Contact Dermatitis 23:51

    Article  PubMed  CAS  Google Scholar 

  • Belsito DV (1993) Contact urticaria from pentamidine isethionate. Contact Dermatitis 29:158–159

    Article  PubMed  CAS  Google Scholar 

  • Bennett MF, Lowney AC, Bourke JF (2016) A study of occupational contact dermatitis in the pharmaceutical industry. Br J Dermatol 174:654–656

    Article  PubMed  CAS  Google Scholar 

  • Benyoussef K, Bottlaender A, Pfister HR, Caussade P, Heid E, Grosshans E (1996) Allergic contact dermatitis from mesna. Contact Dermatitis 34:228–229

    Article  PubMed  CAS  Google Scholar 

  • Berl V, Barbaud A, Lepoittevin J-P (1998) Mechanism of allergic contact dermatitis from propacetamol: sensitization to activated N,N-diethylglycine. Contact Dermatitis 38:185–188

    Article  PubMed  CAS  Google Scholar 

  • Bernstein JA, Stauder T, Bernstein DI, Bernstein IL (1994) A combined respiratory and cutaneous hypersensitivity syndrome induced by work exposure to quaternary amines. J Allergy Clin Immunol 94:257–259

    Article  PubMed  CAS  Google Scholar 

  • Bircher AJ (1996) Arzneimittelallergie und Haut. Georg Thieme, Stuttgart/New York

    Google Scholar 

  • Bircher AJ, Bigliardi P, Langauer Messmer S, Surber C (1999) Occupational airborne contact dermatitis from diphencyprone in a pharmacy employee. Contact Dermatitis 41:52

    Article  PubMed  CAS  Google Scholar 

  • Björkner BE (1994) Industrial airborne dermatoses. Dermatol Clin 12:501–509

    Article  PubMed  Google Scholar 

  • Blancas-Espinosa R, Conde-Salazar L, Pérez-Hortet C (2006) Occupational airborne contact dermatitis from pristinamycin. Contact Dermatitis 54:63–65

    Article  PubMed  CAS  Google Scholar 

  • Bonamonte D, Carino M, Mundo L, Foti C (2002) Occupational airborne allergic contact dermatitis from 2-aminothiophenol. Eur J Dermatol 12:592–593

    PubMed  Google Scholar 

  • Bruijn MS, Lavrijsen APM, Van Zuuren EJ (2009) An unusual case of contact dermatitis to procaine. Contact Dermatitis 60:182–183

    Article  PubMed  CAS  Google Scholar 

  • Burches E, Revert A, Martin J, Iturralde A (2015) Occupational systemic allergic dermatitis caused by sevoflurane. Contact Dermatitis 72:62–63

    Article  PubMed  CAS  Google Scholar 

  • Burden AD, Beck MH (1992) Contact hypersensitivity to azathioprine. Contact Dermatitis 27:329–330

    Article  PubMed  CAS  Google Scholar 

  • Calnan CD (1975) Occupational piperazine dermatitis. Contact Dermatitis 1:126

    PubMed  Google Scholar 

  • Camarasa G, Alomar A (1980) Contact dermatitis to an H2 antagonist. Contact Dermatitis 6:152–153

    Article  PubMed  CAS  Google Scholar 

  • Camarasa JG, Barnadas M (1982) Occupational dermatosis by vitamin K3 sodium bisulphite. Contact Dermatitis 8:268

    Article  PubMed  CAS  Google Scholar 

  • Cannon J, Fitzgerald B, Seed M, Agius R, Jiwany A, Cullinan P (2015) Occupational asthma from tafenoquine in the pharmaceutical industry: implications for QSAR. Occup Med (Lond) 65:256–258

    Article  CAS  Google Scholar 

  • Caraffini S, Assalve D, Stingeni L, Lisi P (1994) Tylosin, an airborne contact allergen in veterinarians. Contact Dermatitis 31:327–328

    Article  PubMed  CAS  Google Scholar 

  • Choi GS, Sung JM, Lee JW, Ye YM, Park HS (2009) A case of occupational asthma caused by inhalation of vancomycin powder. Allergy 64:1391–1392

    Article  PubMed  CAS  Google Scholar 

  • Cockayne SE, Gawkrodger DJ (1997) Occupational contact dermatitis in an aromatherapist. Contact Dermatitis 37:306–307

    Article  PubMed  CAS  Google Scholar 

  • Coenraads PJ, Hogen Esch AJ, Prevoo RLMA (2001) Occupational contact dermatitis from diacetylmorphine (heroin). Contact Dermatitis 45:114

    Article  PubMed  CAS  Google Scholar 

  • Conde-Salazar L, Guimaraens D, Romero L (1984) Occupational contact dermatitis from cytosine arabinoside synthesis. Contact Dermatitis 10:44–45

    Article  PubMed  CAS  Google Scholar 

  • Condé-Salazar L, Guimaraens D, Romero LV, Gonzalez MA (1986) Occupational dermatitis from cephalosporins. Contact Dermatitis 14:70–71

    Article  PubMed  Google Scholar 

  • Condé-Salazar L, Llinás MG, Guimaraens D, Romero L (1988) Occupational allergic contact dermatitis from amethocaine. Contact Dermatitis 19:69–70

    Article  PubMed  Google Scholar 

  • Condé-Salazar L, Guimaraens D, Llinas G, Romero L, González MA (1989) Occupational allergic contact dermatitis from oxolamine. Contact Dermatitis 21:206

    Article  Google Scholar 

  • Conde-Salazar L, Guimaraens D, Gonzalez M, Fuente C (1991) Occupational allergic contact dermatitis from opium alkaloids. Contact Dermatitis 25:202–203

    Article  PubMed  CAS  Google Scholar 

  • Corazza M, Mantovani L, Trimurti S, Virgili A (1994) Occupational contact sensitization to ethylenediamine in a nurse. Contact Dermatitis 31:328–329

    Article  PubMed  CAS  Google Scholar 

  • Dahlquist I (1977) Allergic reactions to apomorphine. Contact Dermatitis 3:349–350

    Article  PubMed  CAS  Google Scholar 

  • Dal Monte A, Laffi G, Mancini G (1994) Occupational contact dermatitis due to spectinomycin. Contact Dermatitis 31:204–205

    Article  PubMed  CAS  Google Scholar 

  • Dastychová E (2003) Allergic contact dermatitis in methotrexate manufacture. Contact Dermatitis 48:226

    Article  PubMed  Google Scholar 

  • Dastychová E, Semrádová V (2000) A case of contact hypersensitivity to platinum salts. Contact Dermatitis 43:226

    PubMed  Google Scholar 

  • Davies MG (1983) Contact allergy to dicyclohexyl-carbodiimide. Contact Dermatitis 9:318

    Article  PubMed  CAS  Google Scholar 

  • De Boer J, Van Joost T (1988) Sensitisation to dichlorobenzoyl chloride. Contact Dermatitis 18: 116–117

    Article  PubMed  Google Scholar 

  • De Groot AC, Conemans JMH (1990) Contact allergy to furazolidone. Contact Dermatitis 22:202–205

    Article  PubMed  Google Scholar 

  • De Groot AC, Van Wijnen WG, Van Wijnen-Vos M (1990) Occupational contact dermatitis of the eyelids, without ocular involvement, from thimerosal in contact lens fluid. Contact Dermatitis 23:195–196

    Article  PubMed  Google Scholar 

  • Deschamps D, Garnier R, Savoye J, Chabaux C, Efthymiou ML, Fournier E (1988) Allergic and irritant contact dermatitis from diethyl-β-chloroethylamine. Contact Dermatitis 18:103–105

    Article  PubMed  CAS  Google Scholar 

  • Dinis A, Bhandão M, Faria A (1988) Occupational contact dermatitis from vitamin K3 sodium bisulphite. Contact Dermatitis 18:170–171

    Article  PubMed  CAS  Google Scholar 

  • Dooms-Goossens A, Gevers D, Mertens A, Vanderheyden D (1983) Allergic contact urticaria due to chloramine. Contact Dermatitis 9:319–320

    Article  PubMed  CAS  Google Scholar 

  • Dooms-Goossens A, De Boulle K, Snauwaert J, Degreef H (1986a) Sensitization to 3,4,6-trichloropyridazine. Contact Dermatitis 14:64–65

    Article  PubMed  CAS  Google Scholar 

  • Dooms-Goossens AE, Debusschere KM, Gevers DM, Dupré KM, Degreef HJ, Loncke JP, Snauwaert JE (1986b) Contact dermatitis caused by airborne agents. A review and case reports. J Am Acad Dermatol 15:1–10

    Article  PubMed  CAS  Google Scholar 

  • Dooms-Goossens A, Bedert R, Degreef H, Vandaele M (1990) Airborne allergic contact dermatitis from kitasamycin and midecamycin. Contact Dermatitis 23:118–119

    Article  PubMed  CAS  Google Scholar 

  • Dorado Bris JM, Aragues Montañes M, Sols Candela M, Garcia Diez A (1992) Contact sensitivity to pyrazinobutazone (Carudol®) with positive oral provocation test. Contact Dermatitis 26:355–356

    Article  PubMed  CAS  Google Scholar 

  • Dziuk M, Gall H, Sterry W (1994) Contact dermatitis from the ACE-inhibitor captopril. Derm Beruf Umwelt 42:159–161

    Google Scholar 

  • Ekenvall L, Forsbeck M (1978) Contact eczema produced by a β-adrenergic blocking agent (alprenolol). Contact Dermatitis 4:190–194

    Article  PubMed  CAS  Google Scholar 

  • Ferran M, Giménez-Arnau A, Luque S, Berenguer N, Iglesias M, Pujol RM (2005) Occupational airborne contact dermatitis from sporadic exposure to tetrazepam during machine maintenance. Contact Dermatitis 52:173–174

    Article  PubMed  Google Scholar 

  • Filipe P, Soares Almeida RSL, Rodrigo FG (1996) Occupational allergic contact dermatitis from cephalosporins. Contact Dermatitis 34:226

    Article  PubMed  CAS  Google Scholar 

  • Finch TM, Muncaster A, Prais L, Foulds IS (2000) Occupational airborne allergic contact dermatitis from isoflurane vapour. Contact Dermatitis 42:46

    PubMed  CAS  Google Scholar 

  • Fisher AA (1991) Allergic contact dermatitis to mitomycin C. Cutis 47:225–227

    PubMed  CAS  Google Scholar 

  • Foti C, Vena GA, Angelini G (1992) Occupational contact allergy to benzydamine hydrochloride. Contact Dermatitis 27:328–329

    Article  PubMed  CAS  Google Scholar 

  • Foti C, Vena GA, Cucurachi MR, Angelini G (1994) Occupational contact allergy from cephalosporins. Contact Dermatitis 31:129–130

    Article  PubMed  CAS  Google Scholar 

  • Foti C, Bonamonte D, Trenti R, Veña GA, Angelini G (1997) Occupational contact allergy to cephalosporins. Contact Dermatitis 36:104–105

    Article  PubMed  CAS  Google Scholar 

  • Foussereau J (1989) Accidental occupational sensitization to p-nitrobenzoyl chloride in a chemistry student synthesizing procaine. Contact Dermatitis 20:397–398

    Article  PubMed  CAS  Google Scholar 

  • Foussereau J, Benezra C, Maibach HI (1982) Occupational contact dermatitis: clinical and chemical aspects. Munksgaard, Kopenhagen

    Google Scholar 

  • Francalanci S, Gola M, Giorgini S, Muccinelli A, Sertoli A (1986) Occupational photocontact dermatitis from olaquindox. Contact Dermatitis 15:112–114

    Article  PubMed  CAS  Google Scholar 

  • Frattasio A, Germino M, Cargnello S, Patrone P (1997) Side-effects during treatment with SADBE. Contact Dermatitis 36:118–119

    Article  PubMed  CAS  Google Scholar 

  • Fumagalli M, Bigardi AS, Legori A, Pigatto PD (1992) Occupational contact dermatitis from airborne nicergoline. Contact Dermatitis 27:256

    Article  PubMed  CAS  Google Scholar 

  • Fung MA, Geisse JK, Maibach HI (1996) Airborne contact dermatitis from metaproterenol in a respiratory therapist. Contact Dermatitis 35:317–318

    Article  PubMed  CAS  Google Scholar 

  • Gamboa P, Jáuregui I, Urrutia I (1995) Occupational sensitization to aminopenicillins with oral tolerance to penicillin V. Contact Dermatitis 32:48–49

    Article  PubMed  CAS  Google Scholar 

  • García-Bravo B, Gines E, Russo F (1995) Occupational contact dermatitis from ceftiofur sodium. Contact Dermatitis 33:62–63

    Article  PubMed  Google Scholar 

  • Garcia-Perez A (1978) Occupational dermatitis from DNFB with cross sensitivity to DNCB. Contact Dermatitis 4:125–127

    Article  PubMed  CAS  Google Scholar 

  • Gastelain PY, Piriou A (1980) Contact dermatitis due to propanidid in an anesthetist. Contact Dermatitis 6:360

    Article  PubMed  CAS  Google Scholar 

  • Gauchía R, Rodríguez-Serna M, Silvestre JF, Linana JJ, Aliaga A (1996) Allergic contact dermatitis from streptomycin in a cattle breeder. Contact Dermatitis 35:374–375

    Article  PubMed  Google Scholar 

  • Goday Buján JJ, Yanguas Bayona I, Soloeta Arechavala R (1994) Allergic contact dermatitis from cyanamide: report of 3 cases. Contact Dermatitis 31:331–332

    Article  PubMed  Google Scholar 

  • Goh CL, Ng SK (1984) Allergic contact dermatitis to ranitidine. Contact Dermatitis 11:252–252

    Article  PubMed  CAS  Google Scholar 

  • Goh CL, Ng SK (1985) Photoallergic contact dermatitis to carbimazole. Contact Dermatitis 12:58–59

    Article  PubMed  CAS  Google Scholar 

  • Gómez Ollés S, Madrid-San Martín F, Cruz M-J, Muñoz X (2010) Occupational asthma due to colistin in a pharmaceutical worker. Chest 137:1200–1202

    Article  PubMed  Google Scholar 

  • Goossens A, Hulst KV (2011) Occupational contact dermatitis in the pharmaceutical industry. Clin Dermatol 29:662–668

    Article  PubMed  Google Scholar 

  • Guerra L, Venturo N, Tardio M, Tosti A (1991) Airborne contact dermatitis from animal feed antibiotics. Contact Dermatitis 25:333–334

    Article  PubMed  CAS  Google Scholar 

  • Guimaraens D, Gonzales MA, Condé-Salazar L (1994) Occupational allergic contact dermatitis from intermediate products in famotidine synthesis. Contact Dermatitis 31:259–260

    Article  PubMed  CAS  Google Scholar 

  • Haddar M, Araibia A, Laibldder C, Mekki R, Benmami F (1993) Contact dermatitis due to ethylene oxide. Arch Mal Prof Med Trav Secur Soc 54:358–359

    Google Scholar 

  • Happle R, Kalveram KJ, Büchner U, Echternacht-Happle K, Göggelmann W, Summer KH (1980) Contact allergy as a therapeutic tool for alopecia areata: application of squaric acid dibutylester. Dermatologica 161:289–297

    Article  PubMed  CAS  Google Scholar 

  • Hardie RA, Savin JA, White DA, Pumford S (1978) Quinine dermatitis: investigation of a factory outbreak. Contact Dermatitis 4:121–124

    Article  PubMed  CAS  Google Scholar 

  • Harle DG, Baldo BA, Coroneos NJ, Fisher MM (1989) Anaphylaxis following administration of papaveretum. Case report: implication of IgE antibodies that react with morphine and codeine, and identification of an allergenic determinant. Anesthesiology 71:489–494

    Article  PubMed  CAS  Google Scholar 

  • Hausen BM (1980) Arnikaallergie. Hautarzt 31:10–17

    PubMed  CAS  Google Scholar 

  • Häusermann P, Harr T, Bircher AJ (2004) Baboon syndrome resulting from systemic drugs: is there strife between SDRIFE and allergic contact dermatitis syndrome? Contact Dermatitis 51:297–310

    Article  PubMed  Google Scholar 

  • Heidenheim M, Jemec GBE (1995) Occupational allergic contact dermatitis from vitamin A acetate. Contact Dermatitis 33:439

    Article  PubMed  CAS  Google Scholar 

  • Herrera-Mozo I, Sanz-Gallen P, Martí-Amengual G (2017) Occupational contact allergy to omeprazole and ranitidine. Med Pr 68:433–435

    PubMed  Google Scholar 

  • Hjorth N, Weismann K (1973) Occupational dermatitis among veterinary surgeons caused by spiramycin, tylosin, and penethamate. Acta Derm Venereol 53:229–232

    PubMed  CAS  Google Scholar 

  • Holdiness MR (1986a) Contact dermatitis to ethambutol. Contact Dermatitis 15:96–97

    Article  PubMed  CAS  Google Scholar 

  • Holdiness MR (1986b) Contact dermatitis to antituberculosis drugs. Contact Dermatitis 15:282–288

    Article  PubMed  CAS  Google Scholar 

  • Hsu CK, Sun CC, Su MS, Kuo EF, Wu YC (1992) Systemic contact allergy from occupational contact with ethyl ethoxymethylene cyanoacetate. Contact Dermatitis 27:58–59

    Article  PubMed  CAS  Google Scholar 

  • Ingemann Larsen A, Jepsen JR, Thulin H (1989) Allergic contact dermatitis from thiamine. Contact Dermatitis 20:387–388

    Article  PubMed  CAS  Google Scholar 

  • Isaksson M, Bruze M, Gruvberger B, Ljunggren B (1994) Quinine and quinidine photoproducts can be identical. Acta Derm Venereol 74:286–288

    PubMed  CAS  Google Scholar 

  • Johansson G (1988) Contact urticaria from levomepromazine. Contact Dermatitis 19:304

    Article  PubMed  CAS  Google Scholar 

  • Jolanki R, Alanko K, Pfäffli P, Estlander T, Kanerva L (1997) Occupational allergic contact dermatitis from 5-chloro-1-methyl-4-nitroimidazole. Contact Dermatitis 36:53–54

    Article  PubMed  CAS  Google Scholar 

  • Jungewelter S, Aalto-Korte K (2008) A new allergen in the pharmaceutical industry. Contact Dermatitis 59:314

    Article  PubMed  CAS  Google Scholar 

  • Kanerva L, Laine R, Jolanki R, Tarvainen K, Estlander T, Helander I (1991) Occupational allergic contact dermatitis caused by nitroglycerin. Contact Dermatitis 24:356–362

    Article  PubMed  CAS  Google Scholar 

  • Kanerva L, Estlander T, Jolanki R (1994) Occupational skin allergy in the dental profession. Dermatol Clin 12:517–532

    Article  PubMed  CAS  Google Scholar 

  • Kanerva L, Alanko K, Estlander T, Sihvonen T, Jolanki R (1997) Occupational allergic contact urticaria from chloramine-T solution. Contact Dermatitis 37:180–181

    Article  PubMed  CAS  Google Scholar 

  • Kanerva L, Jolanki R, Estlander T (2000) Occupational allergic contact dermatitis from benzalkonium chloride. Contact Dermatitis 42:357–358

    PubMed  CAS  Google Scholar 

  • Keller K, Schwanitz HJ (1992) Combined immediate and delayed hypersensitivity to mezlocillin. Contact Dermatitis 27:348–349

    Article  PubMed  CAS  Google Scholar 

  • Kellett JK, Beck MH (1984) Contact sensitivity to chloroquine sulphate. Contact Dermatitis 11:47

    Article  PubMed  CAS  Google Scholar 

  • Kerr AC, Muller F, Ferguson J, Dawe RS (2008) Occupational carprofen photoallergic contact dermatitis. Br J Dermatol 159:1303–1308

    Article  PubMed  CAS  Google Scholar 

  • Kiec-Swierczynska M, Krecisz B (1998) Occupational contact allergy to nifuroxazide simulating prurigo nodularis. Contact Dermatitis 39:93–94

    Article  PubMed  CAS  Google Scholar 

  • Kiely C, Murphy G (2010) Photoallergic contact dermatitis caused by occupational exposure to the canine non-steroidal anti-inflammatory drug carprofen. Contact Dermatitis 63:364–365

    Article  PubMed  Google Scholar 

  • Kim M-H, Lee J-M (2014) Diagnosis and management of immediate hypersensitivity reactions to cephalosporins. Allergy Asthma Immunol Res 6:485–495

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Klein T, Woehlck H, Pagel P (2009) Severe allergic contact dermatitis resulting from occupational exposure to tincture of benzoin aerosol spray in an anesthesiologist. J Anesth 23:292–294

    Article  PubMed  Google Scholar 

  • Klijn J (1984) Contact dermatitis from spironolactone. Contact Dermatitis 10:105

    Article  PubMed  CAS  Google Scholar 

  • Krautheim AB, Jermann TH, Bircher AJ (2004) Chlorhexidine anaphylaxis: case report and review of the literature. Contact Dermatitis 50:113–116

    Article  PubMed  CAS  Google Scholar 

  • Lahti A, Puurunen J, Hannuksela M (1990) Occupational contact allergy to 2,4-diamino-6-chloromethylpteridine hydrochloride: an intermediate product in methotrexate synthesis. Contact Dermatitis 22:294

    Article  PubMed  CAS  Google Scholar 

  • Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S (2007) Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis 57:89–93

    Article  PubMed  CAS  Google Scholar 

  • Lepoittevin J-P (2006) Metabolism versus chemical transformation or pro- versus prehaptens? Contact Dermatitis 54:73–74

    Article  PubMed  Google Scholar 

  • Lerman Y, Ribak J, Skulsky M, Ingber A (1995) An outbreak of irritant contact dermatitis from ethylene oxide among pharmaceutical workers. Contact Dermatitis 33:280–281

    Article  PubMed  CAS  Google Scholar 

  • Ljunggren B, Hindsén M, Isaksson M (1992) Systemic quinine photosensitivity with photoepicutaneous cross-reactivity to quinidine. Contact Dermatitis 26:1–4

    Article  PubMed  CAS  Google Scholar 

  • Lo JS, Taylor JS, Oriba H (1990) Occupational allergic contact dermatitis to airborne nitrofurazone. Dermatol Clin 8:165–168

    Article  PubMed  CAS  Google Scholar 

  • Lombardi P, Gola M, Acciai MC, Sertoli A (1989) Unusual occupational allergic contact dermatitis in a nurse. Contact Dermatitis 20:302–303

    Article  PubMed  CAS  Google Scholar 

  • Lowney AC, Mcaleer MA, Bourke J (2010) Occupational allergic contact dermatitis to olanzapine. Contact Dermatitis 62:123–124

    Article  PubMed  Google Scholar 

  • Lubbe D (1993) Professional dinitrochlorobenzene contact dermatitis. Eleven cases in the nitration facility of a chemical plant. Derm Beruf Umwelt 41:19–24

    Google Scholar 

  • Macedo NA, Piñeyro MI, Carmona C (1991) Contact urticaria and contact dermatitis from albendazole. Contact Dermatitis 25:73–75

    Article  PubMed  CAS  Google Scholar 

  • Madsen JT, Lorentzen HF, Paulsen E (2009) Contact sensitization to metronidazole from possible occupational exposure. Contact Dermatitis 60:117–118

    Article  PubMed  CAS  Google Scholar 

  • Malaiyandi V, Houle M, Skotnicki Grant S (2012) Airborne allergic contact dermatitis from tylosin in pharmacy compounders and cross-sensitization to macrolide antibiotics. Dermatitis 23:227–230

    Article  PubMed  CAS  Google Scholar 

  • Mancuso G, Staffa M, Errani A, Berdondini RM, Fabbri P (1990) Occupational dermatitis in animal feed mill workers. Contact Dermatitis 22:37–41

    Article  PubMed  CAS  Google Scholar 

  • Marcos ML, Garcés MM, Alonso L, Juste S, Carretero P, Blanco J, Garcia F, Perez R, Herrero D (1997) Occupational allergic contact dermatitis from homatropine and phenylephrine eyedrops. Contact Dermatitis 37:189

    Article  PubMed  CAS  Google Scholar 

  • Martin P, Bétourné M, Martin JJ, Huriez C (1973) Allergie au carbocromène. Bull Soc Fr Dermatol Syphiligr 80:620

    Google Scholar 

  • Mathelier-Fusade P, Leynadier F (1994) Occupational allergic contact reaction to disulfiram. Contact Dermatitis 31:121–122

    Article  PubMed  CAS  Google Scholar 

  • Mathelier-Fusade P, Mansouri S, Aïssaoui M, Chabane MH, Aractingi S, Leynadier F (1997) Airborne contact dermatitis from propacetamol. Contact Dermatitis 36:267–268

    Article  PubMed  CAS  Google Scholar 

  • Meding B (1986) Contact allergy to omeprazole. Contact Dermatitis 15:36–51

    Article  Google Scholar 

  • Meier H, Elsner P, Wüthrich B (1999) Occupationally-induced contact dermatitis and bronchial asthma in a unusual delayed reaction to hydroxychloroquine. Hautarzt 50:665–669

    Article  PubMed  CAS  Google Scholar 

  • Menné T, Veien NK, Maibach HI (1989) Systemic contact-type dermatitis due to drugs. Semin Dermatol 8:144–148

    PubMed  Google Scholar 

  • Merk HF, Baron JM, Neis MM, Obrigkeit DH, Karlberg A-T (2007) Skin: major target organ of allergic reactions to small molecular weight compounds. Toxicol Appl Pharmacol 224:313–317

    Article  PubMed  CAS  Google Scholar 

  • Meyer HW, Stahl Skov P (2010) Occupational rhinosinusitis due to etoposide, an antineoplastic agent. Scand J Work Environ Health 36:266–267

    Article  PubMed  Google Scholar 

  • Milković-Kraus S, Macan J, Kanceljak-Macan B (2007) Occupational allergic contact dermatitis from azithromycin in pharmaceutical workers: a case series. Contact Dermatitis 56:99–102

    Article  PubMed  Google Scholar 

  • Mitchell JC, Maibach HI (1975) Allergic contact dermatitis from phenoxybenzamine hydrochloride. Contact Dermatitis 1:363–366

    Article  PubMed  CAS  Google Scholar 

  • Miyahara H, Koga T, Imayama S, Hori Y (1993) Occupational contact urticaria syndrome from cefotiam hydrochloride. Contact Dermatitis 29:210–211

    Article  PubMed  CAS  Google Scholar 

  • Møller NE, Jeppesen K (1987) Patch testing with semisynthetic penicillins. Contact Dermatitis 16:227–228

    Article  PubMed  Google Scholar 

  • Møller NE, Kromann N (1989) Bumetanide allergy in factory workers. Contact Dermatitis 20:393–394

    Article  PubMed  Google Scholar 

  • Møller NE, Von Würden K (1992) Hypersensitivity to semisynthetic penicillins and cross-reactivity with penicillin. Contact Dermatitis 26:351–352

    Article  PubMed  Google Scholar 

  • Møller NE, Nielsen B, Von Würden K (1986) Contact dermatitis to semisynthetic penicillins in factory workers. Contact Dermatitis 14:307–311

    Article  PubMed  Google Scholar 

  • Møller NE, Nielsen B, Von Würden K (1990) Changes in penicillin contamination and allergy in factory workers. Contact Dermatitis 22:106–107

    Article  PubMed  Google Scholar 

  • Monterseirín J, Conde J (1990) Contact eczema from famotidine. Contact Dermatitis 22:290

    Article  Google Scholar 

  • Moscato G, Galdi E, Scibilia J, Dellabianca A, Omodeo P, Vittadini G, Biscaldi GP (1995) Occupational asthma, rhinitis and urticaria due to piperacillin sodium in a pharmaceutical worker. Eur Respir J 8:467–469

    Article  PubMed  CAS  Google Scholar 

  • Neumark M, Moshe S, Ingber A, Slodownik D (2009) Occupational airborne contact dermatitis to simvastatin, carvedilol, and zolpidem. Contact Dermatitis 61:51–52

    Article  PubMed  Google Scholar 

  • Neumark M, Ingber A, Levin M, Slodownik D (2011) Occupational airborne contact dermatitis caused by pantoprazole. Contact Dermatitis 64:60–61

    Article  PubMed  Google Scholar 

  • Newman M, Goel P (2010) An anesthesiologist with an allergy to multiple neuromuscular blocking drugs: a new occupational hazard. Anesth Analg 110:601–602

    Article  PubMed  Google Scholar 

  • Newton JA, White I (1987) Connubial dermatitis from Morantel. Contact Dermatitis 16:38–39

    Article  PubMed  CAS  Google Scholar 

  • Niklasson B, Björkner B (1990) Contact allergy to 3,4-dicarbethoxyhexane-2,5-dione. Contact Dermatitis 23:46–47

    Article  PubMed  CAS  Google Scholar 

  • Niklasson B, Björkner B, Hansen L (1990) Occupational contact dermatitis from antitumor agent intermediates. Contact Dermatitis 22:233–235

    Article  PubMed  CAS  Google Scholar 

  • Norris PG, Hawk JLM, White IR (1988) Photoallergic contact dermatitis from fentichlor. Contact Dermatitis 18:318–320

    Article  PubMed  CAS  Google Scholar 

  • Noster U, Hausen BM, Krische B, Schulz KH (1976) Squaric acid diethyl ester – a strong sensitizer. Contact Dermatitis 2:99–104

    Article  PubMed  CAS  Google Scholar 

  • Ortiz-Frutos FJ, Alonso J, Hergueta JP, Quintana I, Iglesias L (1995) Tetrazepam: an allergen with several clinical expressions. Contact Dermatitis 33:63–65

    Article  PubMed  CAS  Google Scholar 

  • Pecegueiro M (1990) Occupational contact dermatitis from penicillin. Contact Dermatitis 23:190–191

    Article  PubMed  CAS  Google Scholar 

  • Peramiquel L, Serra E, Dalmau J, Vila AT, Mascaró JM, Alomar A (2005) Occupational contact dermatitis from simvastatin. Contact Dermatitis 52:286–287

    Article  PubMed  Google Scholar 

  • Pickering FC, Ive FA (1982) Allergic contact dermatitis from 4,7-dichloroquinoline. Contact Dermatitis 8: 269–270

    Article  PubMed  CAS  Google Scholar 

  • Piirilä P, Hodgson U, Estlander T, Keskinen H, Saalo A, Voutilainen R, Kanerva L (2002) Occupational respiratory hypersensitivity in dental personnel. Int Arch Occup Environ Health 75:209–216

    Article  PubMed  CAS  Google Scholar 

  • Placucci F, Benini A, Guerra L, Tosti A (1996) Occupational allergic contact dermatitis from disinfectant wipes used in dentistry. Contact Dermatitis 35:306

    Article  PubMed  CAS  Google Scholar 

  • Poesen N, De Moor A, Busschots A, Dooms-Goossens A (1995) Contact allergy to dicyclohexyl carbodiimide and diisopropyl carbodiimide. Contact Dermatitis 32:368–369

    Article  PubMed  CAS  Google Scholar 

  • Quirce S, Olaguibel JM, García BE, Tabar AI (1993) Occupational airborne contact dermatitis due to benzoyl peroxide. Contact Dermatitis 29:165–166

    Article  PubMed  CAS  Google Scholar 

  • Rademaker M (1994) Allergic contact dermatitis from lavender fragrance in Difflam® gel. Contact Dermatitis 31:58–59

    Article  PubMed  CAS  Google Scholar 

  • Rebandel P, Rudzki E (1986a) Dermatitis from quinazoline oxide. Contact Dermatitis 15:63–65

    Article  PubMed  CAS  Google Scholar 

  • Rebandel P, Rudzki E (1986b) Occupational contact sensitivity in oculists. Contact Dermatitis 15:92

    Article  PubMed  CAS  Google Scholar 

  • Rebandel P, Rudzki E (1990) Dermatitis caused by epichlorohydrin, oxprenolol hydrochloride and propranolol hydrochloride. Contact Dermatitis 23:199

    Article  PubMed  CAS  Google Scholar 

  • Riddell CE, Reed J, Shaw S, Duvall-Young J (2000) Allergic contact fingertip dermatitis secondary to proxymetacaine in an ophthalmologist. Eye 14:907–908

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez A, Echechipia S, Alvarez M, Muro MD (1994) Occupational contact dermatitis from vitamin B12. Contact Dermatitis 31:271

    Article  PubMed  CAS  Google Scholar 

  • Romaguera C, Grimalt F (1983) Occupational dermatitis from codeine. Contact Dermatitis 9:170

    Article  PubMed  CAS  Google Scholar 

  • Romaguera C, Grimalt F, Conde-Salazar L (1980) Occupational dermatitis from vitamin K3 sodium bisulfite. Contact Dermatitis 6:355–356

    Article  PubMed  CAS  Google Scholar 

  • Romaguera C, Grimalt F, Vilaplana J (1988) Epidemic of occupational contact dermatitis from ranitidine. Contact Dermatitis 18:177–178

    Article  PubMed  CAS  Google Scholar 

  • Romaguera C, Grimalt F, Vilaplana J (1990) Contact dermatitis caused by intermediate products in the manufacture of clenbuterol, ranitidine base, and ranitidine hydrochloride. Dermatol Clin 8:115–117

    Article  PubMed  CAS  Google Scholar 

  • Rudzki E (1990) Contact sensitivity to systemically administered drugs. Dermatol Clin 8:177–180

    Article  PubMed  CAS  Google Scholar 

  • Rudzki E, Grzywa Z (1977) Occupational piperazine dermatitis. Contact Dermatitis 3:216

    Article  PubMed  CAS  Google Scholar 

  • Rudzki E, Rebandel P (1985) Occupational contact urticaria from penicillin. Contact Dermatitis 13:192

    Article  PubMed  CAS  Google Scholar 

  • Rudzki E, Rebandel P (1991) Hypersensitivity to semisynthetic penicillins but not to natural penicillin. Contact Dermatitis 25:192

    Article  PubMed  CAS  Google Scholar 

  • Rudzki E, Rebandel P (2001) Contact sensitivity to quinazoline oxide. Contact Dermatitis 44:56–57

    Article  PubMed  CAS  Google Scholar 

  • Rudzki E, Rebandel P, Grzywa Z (1989a) Patch tests with occupational contactants in nurses, doctors and dentists. Contact Dermatitis 20:247–250

    Article  PubMed  CAS  Google Scholar 

  • Rudzki E, Rebandel P, Grzywa Z (1989b) Contact allergy in the pharmaceutical industry. Contact Dermatitis 21:121–122

    Article  PubMed  CAS  Google Scholar 

  • Rycroft RJG (1981) Occupational contact sensitization to 2,6-dichloropurine. Contact Dermatitis 7:349–350

    Article  PubMed  CAS  Google Scholar 

  • Rycroft RJG (1983) Allergic contact dermatitis from a novel diamino intermediate, 5-[(2-aminoethyl)thiomethyl]-N,N-dimethyl-2-furanmethanamine, in laboratory synthesis. Contact Dermatitis 9:456–458

    Article  PubMed  CAS  Google Scholar 

  • Sansom JE, Molloy KC, Lovell CR (1995) Occupational sensitization to diphencyprone in a chemist. Contact Dermatitis 32:363

    Article  PubMed  CAS  Google Scholar 

  • Sato K, Kusaka Y, Suganuma N, Nagasawa S, Deguchi Y (2004) Occupational allergy in medical doctors. J Occup Health 46:165–170

    Article  PubMed  Google Scholar 

  • Savini C, Morelli R, Piancastelli E, Restani S (1989) Contact dermatitis due to ethoxyquin. Contact Dermatitis 21:342–343

    Article  PubMed  CAS  Google Scholar 

  • Schauder S, Schröder W, Geier J (1996) Olaquindox-induced airborne photoallergic contact dermatitis followed by transient or persistent light reactions in 15 pig breeders. Contact Dermatitis 35:344–354

    Article  PubMed  CAS  Google Scholar 

  • Schena D, Barba A, Costa G (1996) Occupational contact urticaria due to cisplatin. Contact Dermatitis 34: 220–221

    Article  PubMed  CAS  Google Scholar 

  • Schmidt RJ (1986) Plant dermatitis. Compositae Clin Dermatol 4:46–61

    Article  PubMed  CAS  Google Scholar 

  • Schwank R, Jirásek L (1963) Kontaktallergie gegen Chloramphenicol mit besonderer Berücksichtigung der Gruppensensibilisierung. Hautarzt 14:24–30

    PubMed  CAS  Google Scholar 

  • Schwenck K, Gall H, Sterry W (1994) Aerogene Kontaktdermatitis auf das Neuroleptikum Chlorprothixen. Allergologie 17:467–469

    Google Scholar 

  • Schwensen J, Menné T, Sommerlund M, Andersen K, Mortz C, Zachariae C, Johansen J (2016) Contact allergy in Danish healthcare workers: a retrospective matched case-control study. Acta Derm Venereol 96:237–240

    Article  PubMed  Google Scholar 

  • Selvaag E, Holm J-Ø, Thune P (1995) Allergic contact dermatitis in an aroma therapist with multiple sensitizations to essential oils. Contact Dermatitis 33: 354–355

    Article  PubMed  CAS  Google Scholar 

  • Sherertz EF (1994) Occupational skin disease in the pharmaceutical industry. Dermatol Clin 12:533–536

    Article  PubMed  CAS  Google Scholar 

  • Soni BP, Sherertz EF (1996) Allergic contact dermatitis from azathioprine. Am J Contact Dermat 7:116–117

    PubMed  CAS  Google Scholar 

  • Sonnex TS, Rycroft RJG (1986) Allergic contact dermatitis from chloromethyl heterocyclic intermediates in the synthesis of a histamine antagonist. Contact Dermatitis 14:265–267

    Article  PubMed  CAS  Google Scholar 

  • Stejskal VDM, Olin RG, Forsbeck M (1986) The lymphocyte transformation test for diagnosis of drug-induced occupational allergy. J Allergy Clin Immunol 77: 411–426

    Article  PubMed  CAS  Google Scholar 

  • Straube MD, Freitag M, Altmeyer P, Szliska C (2000) Occupational airborne contact dermatitis from cefazolin. Contact Dermatitis 42:44–45

    PubMed  CAS  Google Scholar 

  • Swinnen I, Ghys K, Kerre S, Constandt L, Goossens A (2014) Occupational airborne contact dermatitis from benzodiazepines and other drugs. Contact Dermatitis 70:227–232

    Article  PubMed  Google Scholar 

  • Szczurko C, Dompmartin A, Michel M, Castel B, Leroy D (1996) Occupational contact dermatitis from propacetamol. Contact Dermatitis 35:299–301

    Article  PubMed  CAS  Google Scholar 

  • Tadokoro K, Niimi N, Ohtoshi T, Nakajima K, Takafuji S, Onodera K, Suzuki S, Muranaka M (1994) Cefotiam-induced IgE-mediated occupational contact anaphylaxis of nurses; case reports, RAST analysis, and a review of the literature. Clin Exp Allergy 24:127–133

    Article  PubMed  CAS  Google Scholar 

  • Tas J, Weissberg D (1958) Allergy to aminophylline. Allergy 12:39–42

    Article  CAS  Google Scholar 

  • Tennstedt D, Dumont-Fruytier M, Lachapelle JM (1978) Occupational allergic contact dermatitis to virginiamycin, an antibiotic used as a food additive for pigs and poultry. Contact Dermatitis 4:133–134

    Article  PubMed  CAS  Google Scholar 

  • Testud F, Descotes J, Evreux JC (1994) Pathologie professionnelle due aux médicaments. Arch Mal Prof 55:279–286

    Google Scholar 

  • Tuomi M-L, Räsänen L (1995) Contact allergy to tylosin and cobalt in a pig-farmer. Contact Dermatitis 33:285

    Article  PubMed  CAS  Google Scholar 

  • Valsecchi R, Cassina P, Cainelli T (1987) Contact toxic epidermal necrolysis. Contact Dermatitis 16:277

    Article  PubMed  CAS  Google Scholar 

  • Valsecchi R, Rohrich O, Cainelli T (1989) Contact allergy to cistoran, an intermediate in ranitidine synthesis. Contact Dermatitis 20:396–397

    Article  PubMed  CAS  Google Scholar 

  • Van Hecke E (1981) Contact sensitivity to vincamine tartrate. Contact Dermatitis 7:53

    Article  PubMed  Google Scholar 

  • Vanuytrecht-Henderickx D, Bourgeois M, Mariën K, Dooms-Goossens A (1986) Occupational fixed eruption by inhalation of pyrazolones. Contact Dermatitis 14:115

    Article  PubMed  CAS  Google Scholar 

  • Veien NK, Hattel T, Justesen O, Nørholm A (1980) Occupational contact dermatitis due to spiramycin and/or tylosin among farmers. Contact Dermatitis 6:410–413

    Article  PubMed  CAS  Google Scholar 

  • Veraldi S, Benelli C, Pigatto PD (1992) Occupational allergic contact dermatitis from minoxidil. Contact Dermatitis 26:211–212

    Article  PubMed  CAS  Google Scholar 

  • Verschaeve A, Loncke J, Dooms-Goossens A (1984) Occupational contrast media dermatitis: meglumine diatrizoate. Contact Dermatitis 11:318–319

    Article  PubMed  CAS  Google Scholar 

  • Vilaplana J, Romaguera C (2001) Allergic contact dermatitis due to lansoprazole, a proton pump inhibitor. Contact Dermatitis 44:47–48

    Article  PubMed  CAS  Google Scholar 

  • Vilaplana J, Grimalt F, Romaguera C (1990) Contact dermatitis from furaltadone in animal feed. Contact Dermatitis 22:232–233

    Article  PubMed  CAS  Google Scholar 

  • Vilaplana J, Romaguera C, Grimalt P (1991) Contact dermatitis from lincomycin and spectinomycin in chicken vaccinators. Contact Dermatitis 24:225–226

    Article  PubMed  CAS  Google Scholar 

  • Waclawski ER, Aldrige R (1995) Occupational dermatitis from thebaine and codeine. Contact Dermatitis 33:51

    Article  PubMed  CAS  Google Scholar 

  • Wahlberg JE, Boman A (1981) Contact sensitivity to quinidine sulfate from occupational exposure. Contact Dermatitis 7:27–31

    Article  PubMed  CAS  Google Scholar 

  • Walker SL, Ead RD, Shackleton DB, Beck MH (2005) Two cases of occupational allergic contact dermatitis to p-aminophenol in pharmaceutical workers manufacturing paracetamol. Contact Dermatitis 52:290–291

    Article  PubMed  CAS  Google Scholar 

  • Walker SL, Ead RD, Beck MH (2006) Occupational photoallergic contact dermatitis in a pharmaceutical worker manufacturing carprofen, a canine nonsteroidal anti-inflammatory drug. Br J Dermatol 154:569–570

    Article  PubMed  CAS  Google Scholar 

  • Walusiak J, Wittczak T, Ruta U, Palczynski C (2002) Occupational asthma due to mitoxantrone. Allergy 57:461–461

    Article  PubMed  Google Scholar 

  • Wang C, Maibach H (2013) Immunologic contact urticaria – the human touch. Cutan Ocul Toxicol 32:154–160

    Article  PubMed  CAS  Google Scholar 

  • Watsky KL, Reynolds K, Berube D, Bayer FJ (1993) Occupational contact dermatitis from tosyl chloride in a chemist. Contact Dermatitis 29:211–212

    Article  PubMed  CAS  Google Scholar 

  • Whitaker P (2016) Occupational allergy to pharmaceutical products. Curr Opin Allergy Clin Immunol 16:101–106

    Article  PubMed  CAS  Google Scholar 

  • Wigger-Alberti W, Elsner P (1997) Occupational contact dermatitis due to pyritinol. Contact Dermatitis 37: 91–92

    Article  PubMed  CAS  Google Scholar 

  • Winkler GC, Perino C, Araya SH, Bechter R, Kuster M, Lovsin Barle E (2015) Classification of dermal sensitizers in pharmaceutical manufacturing. Regul Toxicol Pharmacol 72:501–505

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Allergy Unit, Department of Dermatology, University Hospital, Basel, Switzerland

    Andreas J. Bircher

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  1. Andreas J. Bircher
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Editors and Affiliations

  1. Department of Dermatology, University of Osnabrück, Osnabrück, Niedersachsen, Germany

    Swen Malte John

  2. Department of Dermato-allergology, Gentofte Hospital, Hellerup, Denmark

    Jeanne Duus Johansen

  3. Dept. of Dermatology and Allergology, VU University Medical Centre, Amsterdam, The Netherlands

    Thomas Rustemeyer

  4. Dept. of Dermatology and Allergology, Friedrich Schiller University, Jena, Thüringen, Germany

    Peter Elsner

  5. Department of Dermatology, University of California San Francisco, San Francisco, California, USA

    Howard I. Maibach

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Bircher, A.J. (2018). Drug Allergens. In: John, S., Johansen, J., Rustemeyer, T., Elsner, P., Maibach, H. (eds) Kanerva’s Occupational Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-40221-5_39-2

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