Skip to main content

Phototoxic Dermatitis

  • Living reference work entry
  • First Online:
Kanerva’s Occupational Dermatology
  • 403 Accesses

Abstract

Phototoxicity is more frequent than photoallergy, but it is not always easy to distinguish between these two patterns of photosensitivity.

Phytophotodermatitis from plants containing furocoumarins is one of the main causes of phototoxic contact dermatitis.

Topical and systemic drugs are a frequent cause of photosensitivity, often with phototoxic aspects.

The main clinical pattern of acute phototoxicity is an exaggerated sunburn, but bullae, purpura, pseudoporphyria, photoonycholysis, and dyschromia can also occur.

Exposure to phototoxic drugs is increasingly associated with enhanced skin carcinogenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Adachi T, Satou Y, Satou H, Shibata H, Miwa S, Iwase Y, Yamamoto T, Nishida A, Masutomi N (2015) Assessment of 8-methosypsoralen, lomefloxacin, sparfloxacin, and pirfenidone phototoxicity in long-evans rats. Int J Toxicol 34(1):16–23. https://doi.org/10.1177/1091581814559397

    Article  PubMed  CAS  Google Scholar 

  • Al-Kathiri L, Al-Asmaili A (2016) Diclofenac-induced photo-onycholysis. Oman Med J 31(1):65–68. https://doi.org/10.5001/omj.2016.12

    Article  PubMed  PubMed Central  Google Scholar 

  • Ammoury A, Michaud S, Paul C, Prost-Squarcioni C, Alvarez F, Lamani L, Launay F, Bazex J, Chouini-Lalanne N, Marguery M-C (2008) Photodistribution of blue-gray hyperpigmentation after amiodarone treatment. Molecular characterization of amiodarone in the skin. Arch Dermatol 144:92–96

    Article  PubMed  CAS  Google Scholar 

  • Archier E, Devaux S, Castela E, Gallini A, Aubin F, Le Maître M, Aractingi S et al (2012) Carcinogenic risks of psoralen UV-A therapy and narrowband UV-B therapy in chronic plaque psoriasis: a systematic literature review. JEADV 26(SUPPL 3):22–31. https://doi.org/10.1111/j.1468-3083.2012.04520.x

    Article  PubMed  CAS  Google Scholar 

  • Arias-Santiago SA, Fernández-Pugnaire MA, Almazán-Fernández FM, Serrano-Falcón C, Serrano-Ortega S (2009) Phytophotodermatitis due to Ruta graveolens prescribed for fibromyalgia. Rheumatology (Oxford). 48(11):1401. https://doi.org/10.1093/rheumatology/kep234

    Article  PubMed  Google Scholar 

  • Auffret N, Janssen F, Chevalier P, Guillemain R, Amrein C, Le Beller C (2006) Photosensibilisation Au Voriconazole. Ann Dermatol Vénéreol 133:330–332

    Article  PubMed  CAS  Google Scholar 

  • Avenel-Audrun M, Dulartre H, Goossens A, Jeanmougin M, Comte C, Bernier C, Benkalfate M et al (2010) Octocrylene, an emerging photoallergen. Arch Dermatol 146(7):753–757

    Google Scholar 

  • Baran R, Juhlin L (2002) Photoonycholysis. Photodermatol Photoimmunol Photomed 18:202–207

    Article  PubMed  Google Scholar 

  • Barbaud A, Collet E, Martin S, Granel F, Tréchot P, Lambert D, Schmutz J-L (2001a) Contact sensitization to chlorproéthazine can induce persistent light reaction and cross photoreactions to other phenothiazines. Contact Dermatitis 44:373

    PubMed  CAS  Google Scholar 

  • Barbaud A, Gonçalo M, Bircher A, Bruynzeel D (2001b) Guidelines for performing skin tests with drugs in the investigation of cutaneous adverse drug reactions. Contact Dermatitis 45:321–328

    Article  PubMed  CAS  Google Scholar 

  • Béani JC (2009) Les photosensibilisations graves. Ann Dermatol Vénéreol 136:76–83

    Article  PubMed  Google Scholar 

  • Berghoff AT, English JC (2010) Imatinib mesylate-induced pseudoporphyria. J Am Acad Dermatol 63(1):e14–e16

    Article  PubMed  Google Scholar 

  • Bonamonte D, Foti C, Lionetti N, Rigano L, Angelini G (2010) Photoallergic contact dermatitis to 8-MOP in ficus carica. Contact Dermatitis 62:343–348

    Article  PubMed  CAS  Google Scholar 

  • Brugière C, Stefan A, Morice C, Cornet E, Moreau A, Allouche S, Verneuil L (2014) Vemurafenib skin phototoxicity is indirectly linked to ultraviolet a minimal erythema dose decrease. Br J Dermatol 171(6):1529–1532. https://doi.org/10.1111/bjd.13300

    Article  PubMed  CAS  Google Scholar 

  • Bruynzeel DP, Ferguson J, Andersen K, Gonçalo M, English J, Goossens A, Holzle E et al (2004) Photopatch testing: a consensus methodology for Europe. JEADV 18:679–682

    PubMed  CAS  Google Scholar 

  • Canelas MM, Carlos Cardoso J, Gonçalo M, Figueiredo A (2010) Photoallergic contact dermatitis from benzydamine presenting mainly as lip dermatitis. Contact Dermatitis 63(2):85–88

    Article  PubMed  CAS  Google Scholar 

  • Cardoso JC, Canelas MM, Gonçalo M, Figueiredo A (2009) Photopatch testing with an extended series of photoallergens: a 5-year study. Contact Dermatitis 60(6):325–329. https://doi.org/10.1111/j.1600-0536.2009.01550.x

    Article  PubMed  CAS  Google Scholar 

  • Cazzaniga S, Lecchi S, Bruze M, Chosidow O, Diepgen T, Gonçalo M, Hercogova J, Pigatto PD, Naldi L (2015) Development of a clinical score system for the diagnosis of photoallergic contact dermatitis using a consensus process: item selection and reliability. J EADV 29(7):1376–1381. https://doi.org/10.1111/jdv.12879

    Article  CAS  Google Scholar 

  • Chang C-H, Chang JWC, Hui C-Y, Yang C-H (2009) Severe photosensitivity reaction to vandetanib. J Clin Oncol 27(27):e114–e115. https://doi.org/10.1200/JCO.2009.21.8479

    Article  PubMed  Google Scholar 

  • Collins P, Ferguson J (1994) Photoallergic contact dermatitis to oxybenzone. Br J Dermatol 131:124–129

    Article  PubMed  CAS  Google Scholar 

  • Correia O, Delgado L, Barros MA (1994) Bullous photodermatosis after lomefloxacin. Arch Dermatol 130(6):808–809

    Article  PubMed  CAS  Google Scholar 

  • Cowen EW, Nguyen JC, Miller DD, Mcshane D, Arron ST, Prose NS, Turner ML, Fox LP (2010) Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole. J Am Acad Dermatol 62:31–37

    Article  PubMed  CAS  Google Scholar 

  • Cummins R, Wagner-Weiner L, Paller A (2000) Pseudoporphyria induced by celecoxib in a patient with juvenile rheumatoid arthritis. J Rheumatol 27:2938–2940

    PubMed  CAS  Google Scholar 

  • Darvay A, White IR, Rycroft RJ, Jones AB, Hawk JL, McFadden JP (2001) Photoallergic contact dermatitis is uncommon. Br J Dermatol 145:597–601

    Article  PubMed  CAS  Google Scholar 

  • Dawe RS, Ibbotson SH (2014) Drug-induced photosensitivity. Dermatol Clin 32. Elsevier Inc:363–368. https://doi.org/10.1016/j.det.2014.03.014

    Article  PubMed  CAS  Google Scholar 

  • Devleeschouwer V1, Roelandts R, Garmyn M, Goossens A (2008) Allergic and photoallergic contact dermatitis from ketoprofen: results of (photo) patch testing and follow-up of 42 patients. Contact Dermatitis. 58(3):159–66. https://doi.org/10.1111/j.1600-0536.2007.01296.x

    Article  PubMed  CAS  Google Scholar 

  • Dummer R, Rinderknecht J, Goldinger SM (2012) Ultraviolet A and photosensitivity during vemurafenib therapy. N Engl J Med 366(5):480–481

    Article  PubMed  CAS  Google Scholar 

  • Elkeeb D, Elkeeb L, Maibach H (2012) Photosensitivity: a current biological overview. Cutan Ocul Toxicol 31(4):263–272

    Article  PubMed  Google Scholar 

  • EMCPPTS Taskforce, Kerr AC, Ferguson J, Haylett AK, Rhodes LE, Adamski H, Alomar A et al (2012) A European multicentre photopatch test study. Br J Dermatol 166(5):1002–1009

    Article  CAS  Google Scholar 

  • Emmert B, Schauder S, Palm H, Haliier E, Emmert S (2007) Disabling work-related persistent photosensitivity following photoallergic contact dermatitis from chlorpromazine and olaquindox in a pig breeder. Ann Agric Environ Med 14:329

    PubMed  CAS  Google Scholar 

  • Epaulard O, Villier C, Ravaud P, Chosidow O, Blanche S, Mamzer-Bruneel MF, Thiébaut A, Leccia MT, Lortholary O (2013) A multistep voriconazole-related phototoxic pathway may lead to skin carcinoma: results from a French Nationwide study. Clin Infect Dis 57(12):182–188. https://doi.org/10.1093/cid/cit600

    Article  CAS  Google Scholar 

  • Farhi D, Viguier M, Cosnes A, Reygagne P, Dubertret L, Revuz J, Roujeau JC (2006) Terbinafine-induced subacute cutaneous lupus erythematosus. Dermatology 212:59–65

    Article  PubMed  Google Scholar 

  • Ferguson J (1999) Drug and chemical photosensitivity, 1st edn. Oxford University Press, New York, pp 155–169

    Google Scholar 

  • Fernández-Jorge B, Buján JJG, Paradela S, Mazaira M, Fonseca E (2008) Consort contact dermatitis from piketoprofen. Contact Dermatitis 58:113–115

    Article  PubMed  Google Scholar 

  • Figueiredo A (1994) Fotossensibilidade Aos Anti-Inflamatórios Não Esteróides. Estudo Fisiopatológico (thesis). University of Coimbra, Coimbra

    Google Scholar 

  • Foti C, Bonamonte D, Conserva A, Stingeni L, Lisi P, Lionetti N, Rigano L, Angelini G (2008) Allergic and Photoallergic contact dermatitis from ketoprofen: evaluation of cross-reactivities by a combination of photopatch testing and computerized conformational analysis. Curr Pharm Des 14(27):2833–2839

    Article  PubMed  CAS  Google Scholar 

  • Frick MA, Soler-Palacin P, Nalda AM, Guarmer ME, Nadal CF (2010) Photosensitivity in immunocompromised patients receiving long-term therapy with oral voriconazole. Pediatr Infect Dis J 29(5):480–481

    Article  PubMed  Google Scholar 

  • Fujimoto N, Danno K, Wakabayashi M, Uenishi T, Tanaka T (2009) Photosensitivity with eosinophilia due to Ambroxol and UVB. Contact Dermatitis 60:110–113

    Article  PubMed  CAS  Google Scholar 

  • Gaikwad RP, Mukherjee SS (2016) Pirfenidone induced phototoxic reaction in an elderly man. Indian J Dermatol Venereol Leprol 82(1):101–103. https://doi.org/10.4103/0378-6323.172899

    Article  PubMed  Google Scholar 

  • Gelot P, Dutartre H, Khammari A, Boisrobert A, Schmitt C, Deybach JC, Nguyen JM, Seité S, Dréno B (2013) Vemurafenib: an unusual UVA-induced photosensitivity. Exp Dermatol 22(4):297–298

    Article  PubMed  CAS  Google Scholar 

  • Giacchero D, Ramacciotti C, Arnault JF, Brassard M, Baudin E, Maksimovic L, Mateus C et al (2012) A new spectrum of skin toxic effects associated with the multikinase inhibitor vandetanib. Arch Dermatol 148(12):2012–2014

    Article  Google Scholar 

  • Glatz M, Hofbauer GFL (2012) Phototoxic and photoallergic cutaneous drug reactions. Adverse Cutaneous Drug Eruptions 97:167–179. https://doi.org/10.1159/000335630

    Article  CAS  Google Scholar 

  • Goetze S, Hiernickel C, Elsner P (2017) Phototoxicity of doxycycline: a systematic review on clinical manifestations, frequency, cofactors, and prevention. Skin Pharmacol Physiol 30(2):76–80. https://doi.org/10.1159/000458761

    Article  PubMed  CAS  Google Scholar 

  • Gonçalo M (1998) Explorations Dans Les photo-Allergies Médicamenteuses. In: GERDA (ed) Progrès En Dermato-Allergologie. John Libbey Eurotext, Nancy, pp 67–74

    Google Scholar 

  • Gonçalo M (2004) Dermatitis Por Plantas Y Maderas. In: Conde-Salazar Gómez L, Anacona-Alayón A (eds) Dermatología Profesional. Aula Médica Ediciones, Madrid, pp 193–210

    Google Scholar 

  • Gonçalo M (2011) Phototoxic and photoallergic reactions. In: Johansen JD, Frosch P, Lepoittevin JP (eds) Contact dermatitis, 5th edn. Springer, Berlin-Heidelberg, pp 361–376

    Chapter  Google Scholar 

  • Gonçalo M (2016) Photoreactions and phototesting. In: Johansen JD, Lepoittevin J-P, Thyssen JP (eds) Quick guide to contact dermatitis. Springer, Berlin/Heidelberg, pp 4–7. https://doi.org/10.1007/978-3-662-47714-4

    Chapter  Google Scholar 

  • Gonçalo M, Figueiredo A (1992) Photopatch testing with nonsteroidal anti-inflammatory drugs. In: Proceedings of the 1st European symposium of contact dermatitis. Brussels, pp 25

    Google Scholar 

  • Gonçalo M, Giménez-Arnau A (2015) Drug photosensitivity. In: Katsambas AD, Lotti TM, Dessini C, D’Erme AM (eds) European handbook of dermatological treatments, 3rd edn. Springer, Berlin-H, pp 233–251. https://doi.org/10.1007/978-3-662-45139-7

    Chapter  Google Scholar 

  • Gonçalo S, Correia C, Couto JS, Gonçalo M (1989) Contact and photocontact dermatitis from Ruta Chalepensis. Contact Dermatitis 21(3):200–201

    Article  PubMed  Google Scholar 

  • Gonçalo S, Gil J, Gonçalo M, Poiares Baptista A (1991) Pigmented photoallergic contact dermatitis from musk ambrette. Contact Dermatitis 24:229–231

    Article  PubMed  Google Scholar 

  • Gonçalo M, Figueiredo A, Tavares P, Fontes Ribeiro CA, Teixeira F, Poiares Baptista A (1992) Photosensitivity to piroxicam: absence of cross reaction with tenoxicam. Contact Dermatitis 27:287–290

    Article  PubMed  Google Scholar 

  • Gonçalo M, Domingues JC, Correia O, Figueiredo A (1999) Fotossensibilidad a flutamida. Boletim Informativo Del GEIDC 29:45–48

    Google Scholar 

  • Gonçalo M, Ferguson J, Bonevalle A, Bruynzeel DP, Giménez-Arnau A, Goossens A, Kerr A et al (2013) Photopatch testing: recommendations for a European photopatch test baseline series. Contact Dermatitis 68(4):239–243. https://doi.org/10.1111/cod.12037

    Article  PubMed  Google Scholar 

  • Goyal RK (2015) Voriconazole-associated phototoxic dermatoses and skin cancer. Expert Rev Anti-Infect Ther 13(12):1537–1546. https://doi.org/10.1586/14787210.2015.1102053

    Article  PubMed  CAS  Google Scholar 

  • Gregoriou S, Karagiorga T, Stratigos A, Volonakis K, Kontochristopoulos G, Rigopoulos D (2008) Photo-Onycholysis caused by olanzapine and aripiprazole. J Clin Psychopharmacol 28:219–220

    Article  PubMed  Google Scholar 

  • Hariva T, Kitamura K, Osawa J, Ikezawa Z (1993) A cross-reaction between piroxicam-photosensitivity and thiosalicylate hypersensitivity in lymphocyte proliferation test. J Dermatol Sci 5(3):165–174

    Article  Google Scholar 

  • Hawk JLM (1999) Photodermatology, 1st edn. Oxford University Press, New York

    Google Scholar 

  • Hawk JLM (2004) Chronic actinic dermatitis. Photodermatol Photoimmunol Photomed 20:312–314

    Article  PubMed  CAS  Google Scholar 

  • Haylett AK, Felton S, Denning DW, Rhodes LE (2013) Voriconazole-induced photosensitivity: photobiological assessment of a case series of 12 patients. Br J Dermatol 168(1):179–185

    Article  PubMed  CAS  Google Scholar 

  • Hickman G, Duval A, Picard C, Petit A (2010) Porphyrie Cutanée Tardive Révélée Par Le Voriconazole. Ann Dermatol Venereol 137(1):36–39

    Article  PubMed  CAS  Google Scholar 

  • Hindsén M, Isaksson M, Persson L, Zimersson E, Bruze M (2004) Photoallergic contact dermatitis from ketoprofen induced by drug-contaminated personal objects. J Am Acad Dermatol 50:215–219

    Article  PubMed  Google Scholar 

  • Ikezawa Z, Kitamura K, Osawa J, Hariva T (1992) Photosensitivity to piroxicam is induced by sensitization to thimerosal and thiosalicylate. J Invest Dermatol 98(6):918–920

    Article  PubMed  CAS  Google Scholar 

  • Imai S, Atarashi K, Ikesue K, Akiyama K, Tokura Y (2005) Establishment of murine model of allergic photocontact dermatitis to ketoprofen and characterization of pathogenic T cells. J Dermatol Sci 41:127–136

    Article  PubMed  CAS  Google Scholar 

  • Jensen A, Thomsen HF, Engebjerg MC, Olesen AB, Sorensen HT, Karagas MR (2008) Use of Photosensitising diuretics and risk of skin cancer: a population based case-control study. Br J Cancer 99:1522–1528

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jiang C, Huang H, Liu J, Wang Y, Zhiwei L, Zuojun X (2012) Adverse events of pirfenidone for the treatment of pulmonary fibrosis: a meta-analysis of randomized controlled trials. PLoS One 7(10):e47024. https://doi.org/10.1371/journal.pone.0047024

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Johansen JD, Aalto-Korte K, Agner T, Andersen KE, Bircher A, Bruze M, Cannavó A et al (2015) European society of contact dermatitis guideline for diagnostic patch testing – recommendations on best practice. Contact Dermatitis 73(4):195–221. https://doi.org/10.1111/cod.12432

    Article  PubMed  Google Scholar 

  • Karagas MR, Stukel TA, Umland V, Tsoukas MM, Mott LA, Sorensen HT, Jensen AO et al (2007) Reported use of photosensitizing medications and basal cell and squamous cell carcinoma of the skin: results of a population-based case-control study. J Invest Dermatol 127(12):2901–2903. https://doi.org/10.1038/sj.jid.5700934

    Article  PubMed  CAS  Google Scholar 

  • Karimian-Teherani D, Kinaciyan T, Tanew A (2008) Photoallergic contact dermatitis from Heracleum giganteum. Photodermatol Photoimmunol Photomed 24:99–101

    Article  PubMed  Google Scholar 

  • Katsarou A, Makris M, Zarafonitis G, Lagogianni E, Gregoriou S, Kalogeromitros D (2008) Photoallergic contact dermatitis:the 15-year experience of a tertiary reference center in a sunny Mediterranean city. Int J Immunopathol Pharmacol 21:725–727

    Article  PubMed  CAS  Google Scholar 

  • Kerr AC, Ferguson J, Ibbotson SH (2007) Acute phototoxicity with urticarial features during topical 5-Aminolaevulinic acid photodynamic therapy. Clin Exp Dermatol 32(2):201

    Article  PubMed  CAS  Google Scholar 

  • Kerr AC, Muller F, Ferguson J, Dawe RS (2008a) Occupational carprofen photoallergic contact dermatitis. Br J Dermatol 159:1303–1308

    Article  PubMed  CAS  Google Scholar 

  • Kerr AC, Woods J, Ferguson J (2008b) Photocontact allergic and phototoxic studies of chlorproethazine. Photodermatol Photoimmunol Photomed 24:11–15

    Article  PubMed  CAS  Google Scholar 

  • Khandpur S, Porter RM, Boulton SJ, Anstey A (2017) Drug-induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science. Br J Dermatol 176(4):902–909. https://doi.org/10.1111/bjd.14935

    Article  PubMed  CAS  Google Scholar 

  • Kim K, Park H, Lim KM (2015) Phototoxicity: its mechanism and animal alternative test methods. Toxicol Res 31(2):97–104. https://doi.org/10.5487/TR.2015.31.2.157

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kimura M, Kawada A (1998) Photosensitivity induced by lomefloxacin with cross-photosensitivity to ciprofloxacin and fleroxacin. Contact Dermatitis 38(3):180

    Article  PubMed  CAS  Google Scholar 

  • Klecak G, Urbach F, Urwyler H (1997) Fluoroquinolone antibacterials enhance UVA-induced skin tumors. J Photochem Photobiol B 37:174–181

    Article  PubMed  CAS  Google Scholar 

  • Klimaszyk P, Klimaszyk D, Piotrowiak M, Popiołek A (2014) Unusual complications after occupational exposure to giant hogweed (Heracleum mantegazzianum): a case report. Int J Occup Med Environ Health 27(1):141–144. https://doi.org/10.2478/s13382-014-0238-z

    Article  PubMed  Google Scholar 

  • Kosior DA (2014) Cutaneous adverse reactions of amiodarone. Med Sci Monit 20:2369–2372. https://doi.org/10.12659/MSM.890881

    Article  PubMed  PubMed Central  Google Scholar 

  • Kurumajin Y, Shono M (1992) Scarified photopatch testing in lomefloxacin photosensitivity. Contact Dermatitis 26:5–10

    Article  Google Scholar 

  • Kuznetsov AV, Weisenseel P, Flaig MJ, Ruzicka T, Prinz JC (2011) Photoallergic erythroderma due to doxycycline therapy of erythema chronicum migrans. Acta Derm Venereol 91(6):734–736. https://doi.org/10.2340/00015555-1161

    Article  PubMed  Google Scholar 

  • La Cuadra-Oyanguren J, Pérez-Ferriols A, Lecha-Carralero M, Giménez-Arnau AM, Fernández-Redondo V, Ortiz de Frutos FJ, Silvestre-Salvador JF, Serra-Baldrich E (2007) Results and assessment of photopatch testing in Spain: towards a new standard set of photoallergens. Actas Dermosifiliogr 98:96–101

    Article  PubMed  Google Scholar 

  • Lamond NWD, Younis T, Purdy K, Dorreen MS (2013) Drug-induced subacute cutaneous lupus erythematosus associated with nab-paclitaxel therapy. Curr Oncol 20(5):e484–e487. https://doi.org/10.3747/co.20.1546

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lasa Elgezua O, Gorrotxategi PE, Gardeazabal Gracia J, Ratón Nieto JA, Pérez JL (2004) Photoallergic hand eczema due to benzydamine. Eur J Dermatol 14(1):69–70

    PubMed  CAS  Google Scholar 

  • LeCoz CJ, Bottlaender A, Scrivener JN, Santinelli F, Cribier BJ, Heid E, Grosshans EM (1998) Photocontact dermatitis from ketoprofen and tiaprofenic acid: cross-reactivity study in 12 consecutive patients. Contact Dermatitis. 38(5):245–52

    Article  PubMed  Google Scholar 

  • Lenfestey A, Friedmann D, Burke WA (2012) Metformin-induced pseudoporphyria. J Drugs Dermatol 11(11):1272

    PubMed  Google Scholar 

  • Leonard F, Adamski H, Bonnevalle A, Bottlaender A, Bourrain JL, Goujon-Henry G, Leroy D et al (2005) Étude Prospective Multicentrique 1991-2001 de La Batterie Standard Des Photopatch-Tests de La Société Française de Photodermatologie. Ann Dermatol Vénéreol 132:313–320

    Article  PubMed  CAS  Google Scholar 

  • Lhiaubet-Vallet V, Bosca F, Miranda MA (2009) Photosensitized DNA damage: the case of fluoroquinolones. Photochem Photobiol 85:861–868

    Article  PubMed  CAS  Google Scholar 

  • Ljunggren B (1977) Psoralen photoallergy caused by plant contact. Contact Dermatitis 3:85–90

    Article  PubMed  CAS  Google Scholar 

  • Lovell CR (2000) Phytophotodermatitis. CRC Press, Boca Raton, pp 51–65

    Google Scholar 

  • Lovell CR, Cronin E, Rhodes EL (1986) Photocontact urticaria from chlorpromazine. Contact Dermatitis 14:290–291

    Article  PubMed  CAS  Google Scholar 

  • Lowe NJ (2006) An overview of ultraviolet radiation, sunscreens and photo-induced dermatosis. Dermatol Clin 24:9–17

    Article  PubMed  CAS  Google Scholar 

  • Mang R, Stege H, Krutmann J (2011) Mechanisms of phototoxic and photoallergic reactions. In: Johansen JD, Frosch PJ, Lepoittevin J-P (eds) Contact dermatitis, 5th edn. Springer, Berlin/Heidelberg, pp 155–163

    Chapter  Google Scholar 

  • Marrot L, Belaïdi JP, Jones C, Perez P, Riou L, Sarasin A, Meunier JR (2003) Molecular responses to photogenotoxic stress induced by the antibiotic lomefloxacin in human skin cells: from DNA damage to apoptosis. J Invest Dermatol 121:596–606

    Article  PubMed  CAS  Google Scholar 

  • McCarthy KL, Playforf EG, Looke DFM, Whitby M (2007) Severe photosensitivity causing multifocal squamous cell carcinomas secondary to prolonged voriconazole therapy. Clin Inf Dis 44:e55–e56

    Article  CAS  Google Scholar 

  • Miller DD, Cowen EW, Nguyen JC, McCalmont TH, Fox LP (2010) Melanoma associated with long-term voriconazole therapy: a new manifestation of chronic photosensitivity. Arch Dermatol 146(3):300–304

    Article  PubMed  CAS  Google Scholar 

  • Moghaddam S, Connolly D (2014) Photo-induced Stevens-Johnson syndrome. J Am Acad Dermatol 71(3). American Academy of Dermatology, Inc:e82–e83. https://doi.org/10.1016/j.jaad.2014.02.033

    Article  PubMed  Google Scholar 

  • Möller H (1990) Contact and photocontact allergy to psoralens. Photodermatol Photoimmunol Photomed 7:43–44

    PubMed  Google Scholar 

  • Monteagudo-Paz A, Salvador JS, Martinez NL, Granados PA, Martínez PS (2011) Pulpitis as clinical presentation of photoallergic contact dermatitis due to chlorpromazine. Allergy 66(11):1503–1504. https://doi.org/10.1111/j.1398-9995.2011.02688.x

    Article  PubMed  CAS  Google Scholar 

  • Monteiro AF, Rato M, Martins C (2016) Drug-induced photosensitivity: photoallergic and phototoxic reactions. Clin Dermatol 34(5). Elsevier Inc):571–581. https://doi.org/10.1016/j.clindermatol.2016.05.006

    Article  PubMed  Google Scholar 

  • Müller L, Kasper P, kersten B, Zhang J (1998) Photochemical genotoxicity and photochemical carcinogenesis – two sides of a coin? Toxicol Lett 102–103:383–387

    Article  PubMed  Google Scholar 

  • Murad, A, Shudell E, Mulligan N (2015) Rowell’s syndrome induced by terbinafine. BMJ Case reports 2015 (may27_1): bcr2015210360-. https://doi.org/10.1136/bcr-2015-210360

  • Neumann NJ, Holzle E, Lehmann P, Benedikter S, Tapernoux B, Plewig G (1994) Patterns analysis of photopatch test reactions. Photodermatol Photoimmunol Photomed 16:65–73

    Google Scholar 

  • Neumann NJ, Holzle E, Plewig G, Schwatz T, Pannizzon RG, Breit R, Ruzicka T, Lehmann P (2000) Photopatchtesting: the 12-year experience of the German, Austrian and Swiss photopatch test group. J Am Acad Dermatol 42:183–192

    Article  PubMed  CAS  Google Scholar 

  • Neves B, Cruz MT, Francisco V, Gonçalo M, Figueiredo A, Duarte CB, Lopes MC (2008) Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers and irritants in the FSCD cell line. Toxicol Lett 177:74–82

    Article  PubMed  CAS  Google Scholar 

  • Oliveira HS, Gonçalo M, Figueiredo A (1996) Photosensitivity from lomefloxacine. A clinical and photobiological study. Photodermatol Photoimmunol Photomed 16:116–120

    Article  Google Scholar 

  • Oliveira A, Sanches M, Selores M (2011) Azathioprine-induced pellagra. J Dermatol 38(10):1035–1037

    Article  PubMed  Google Scholar 

  • Onoue S, Seto Y, Sato H, Nishida H, Hirota M, Ashikaga T, Api AM, Basketter D, Tokura Y (2017) Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments. J Dermatol Sci 85(1). Japanese Society for Investigative Dermatology):4–11. https://doi.org/10.1016/j.jdermsci.2016.08.005

    Article  PubMed  CAS  Google Scholar 

  • Palumbo F, Garcia-Lainez G, Limones-Herrero D, Coloma MD, Escobar J, Jiménez MC, Miranda MA, Andreu I (2016) Enhanced photo(geno)toxicity of demethylated chlorpromazine metabolites. Toxicol Appl Pharmacol 313:131–137

    Article  PubMed  CAS  Google Scholar 

  • Papakonstantinou E, Prasse A, Schacht V, Kapp A, Raap U (2016) Pirfenidone-induced severe phototoxic reaction in a patient with idiopathic lung fibrosis. J EADV 30(8):1354–1356. https://doi.org/10.1111/jdv.13657

    Article  CAS  Google Scholar 

  • Passier A, Smits-van Herwaarden A, van Puijenbroek E (2004) Photo-Onycholysis associated with the use of doxycycline. BMJ 329:265

    Article  PubMed  PubMed Central  Google Scholar 

  • Peiser M, Tralau T, Heidler J, Api AM, Arts JHE, Basketter DA, English J et al (2012) Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects. Current knowledge assembled at an international workshop at BfR, Germany. Cell Mol Life Sci 69(5):763–781

    Article  PubMed  CAS  Google Scholar 

  • Pérez-Bustillo A, Sánchez-Sambucety P, Suárez-Amor O, Rodríiguez-Prieto MA (2008) Torasemide-induced pseudoporphyria. Arch Dermatol 144(6):812–813

    Article  PubMed  Google Scholar 

  • Pigatto P, Bigardi A, Legori A, Valsecchi R, Picardo M (1996) Cross-reactions in patch testing and photopatch testing with ketoprofen, thiaprophenic acid, and cinnamic aldehyde. Am J Contact Dermat. 7(4):220–3

    Article  CAS  Google Scholar 

  • Placzek M, Eberlein-könig B, Przybilla B (1999) Association between actinic keratoses and potentially photosensitizing drugs. N Engl J Med 341:1474–1475

    Article  PubMed  CAS  Google Scholar 

  • Quaiser S, Kahn R, Khan AS (2015) Drug induced pseudoporphyria in CKD: a case report. Indian J Nephrol 25(5):307–309

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Redondo V, Vicente J, España A, Subira ML, De Filipe I, Quintanilla E (1996) Photo-induced toxic epidermal necrolysis caused by clobazam. Br J Dermatol 135:999–1002

    Article  PubMed  CAS  Google Scholar 

  • Riahi RR, Cohen PR (2011) Voriconazole-associated phototoxicity. Dermatol Online J 17(2):15

    PubMed  Google Scholar 

  • Rok J, Buszman E, Beberok A, Delijewski M, Otręba M, Wrzes̈niok D (2015) Modulation of melanogenesis and antioxidant status of melanocytes in response to phototoxic action of doxycycline. Photochem Photobiol 91(6):1429–1434. https://doi.org/10.1111/php.12497

    Article  PubMed  CAS  Google Scholar 

  • Santo Domingo D, Stevenson ML, Auerbach J, Lerman J (2011) Finasteride-induced pseudoporphyria. Arch Dermatol 147(6):747–748

    Article  PubMed  Google Scholar 

  • Schempp CM, Müller KA, Winghofer B, Schöpf E, Simon JC (2002) St. John’s wort (Hypericum perforatum L.). A plant with relevance for dermatology. Hautartz 53(5):316–321

    Article  CAS  Google Scholar 

  • Schmutz J-L, Barbaud A, Tréchot P (2006) Pseudoporphyria and coxib. Ann Dermatol Vénéreol 133:213

    Article  PubMed  Google Scholar 

  • Schmutz J-L, Barbaud A, Tréchot P (2008) Ciprofloxacin and pseudoporphyria. Ann Dermatol Vénéreol 135(11):804

    Article  PubMed  Google Scholar 

  • Seto Y, Ochi M, Onoue S, Yamada S (2010) High-throughput screening strategy for photogenotoxic potential of Pharmaceutical substances using fluorescent intercalating dye. J Pharm Biomed Anal 52(5):781–786

    Article  PubMed  CAS  Google Scholar 

  • Sheu J, Hawryluk EB, Guo D, London WB, Huang JT (2015) Voriconazole phototoxicity in children: a retrospective review. J Am Acad Dermatol 72(2). Elsevier Inc):314–320. https://doi.org/10.1016/j.jaad.2014.10.023

    Article  PubMed  CAS  Google Scholar 

  • Sheuer E, Warshaw E (2006) Sunscreen allergy: a review of epidemiology, clinical characteristics, and responsible allergens. Dermatitis 17:3–11

    Article  Google Scholar 

  • Siiskonen SJ, Koomen ER, Visser LE, Herings RMC, Guchelaar HJ, Stricker BHC, Nijsten TEC (2013) Exposure to phototoxic NSAIDs and quinolones is associated with an increased risk of melanoma. Eur J Clin Pharmacol 69(7):1437–1444. https://doi.org/10.1007/s00228-013-1476-x

    Article  PubMed  CAS  Google Scholar 

  • Sontheimer RD, Henderson CL, Grau RH (2008) Drug-induced subacute cutaneous lupus erythematosus: a paradigm for bedside-to-bench patient-oriented translational clinical investigation. Arch Dermatol Res 301(1):65–70

    Article  PubMed  Google Scholar 

  • Stern RS (2012) The risk of squamous cell and basal cell cancer associated with psoralen and ultraviolet a therapy: a 30-year prospective study. J Am Acad Dermatol 66(4):553–562

    Article  PubMed  CAS  Google Scholar 

  • Stingeni L, Foti C, Cassano N, Bonamonte D, Vonella M, Vena GA, Angelini G, Lisi P (2010) Photocontact allergy to arylpropionic acid non-steroidal anti-inflammatory drugs in patients sensitized to fragrance mix I. Contact Dermatitis 63(2):108–110. https://doi.org/10.1111/j.1600-0536.2010.01755.x

    Article  PubMed  Google Scholar 

  • Teixeira A, Morliere P, Ferreira J, Conte MA, Galmiche A, Maziere JC, Santus R, Filipe P (2016) Interplay between membrane lipid peroxidation and photoproduct formation in the ultraviolet A-induced phototoxicity of vemurafenib in skin keratinocytes. Toxicol Sci. https://doi.org/10.1093/toxsci/kfw159

  • Timmer-de Mik L, Kardaun SH, Krammer MH, Hayes DP, Bousema MT (2009) Imatinib-induced pseudoporphyria. Clin Exp Dermatol 34(6):705–707

    Article  PubMed  CAS  Google Scholar 

  • Tolland JP, McKeown PP, Corbett JR (2007) Voriconazole-induced pseudoporphyria. Photodermatol Photoimmunol Photomed 23:29–31

    Article  PubMed  CAS  Google Scholar 

  • Urbina F, Barrios M, Sudy E (2006) Photolocalized purpura during ciprofloxacin therapy. Photodermatol Photoimmunol Photomed 22:111–112

    Article  PubMed  Google Scholar 

  • Vassileva SG, Matev G, Parish LC (1998) Antimicrobial photosensitive reactions. Arch Intern Med 158:1993–2000

    Article  PubMed  CAS  Google Scholar 

  • Vilaplana J, Romaguera C, Azón A, Lecha M (1990) Flutamide photosensitivity-residual vitiliginous lesions. Contact Dermatitis 38(2):68–70

    Article  Google Scholar 

  • Wagner AM, Wu JJ, Hansen RC, Nigg HN, Beiere RC (2002) Bullous phytophotodermatitis associated with high natural concentrations of furanocoumarins in limes. Am J Contact Dermat 13(1):10–14

    Article  PubMed  Google Scholar 

  • Walker SL, Ead RD, Beck MH (2006) Occupational photoallergic contact dermatitis in a pharmaceutical worker manufacturing carprofen, a canine nonsteroidal anti-inflammatory drug. Br J Dermatol 154:551–577

    Article  Google Scholar 

  • Watanabe T, Hgaki H, Yamada N, Yoshida Y, Yamamoto O (2009) Photoallergic contact dermatitis in a pig farmer, caused by cotrimoxazole. Eur J Dermatol 19(5):526–527

    PubMed  Google Scholar 

  • Waters AJ, Sandhu DR, Lowe G, Ferguson J (2009) Photocontact allergy to PABA: the need for continous vigilance. Contact Dermatitis 60(3):172–173

    Article  PubMed  CAS  Google Scholar 

  • Wlodek C, Narayan S (2014) A reminder about photo-Onycholysis induced by tetracycline, and the first report of a case induced by lymecycline. Clin Exp Dermatol 39:746–747

    Article  PubMed  CAS  Google Scholar 

  • Yazici AC, Baz K, Ikizoglu G, Kokturk A, Uzumlu H, Tataroglu C (2004) Celecoxib-induced photoallergic drug eruption. Int J Dermatol 43(6):459–461

    Article  PubMed  Google Scholar 

  • Zaheer MR, Gupta A, Iqbal J, Zia Q, Ahmad A, Roohi MO et al (2016) Molecular mechanisms of drug photodegradation and photosensitization. Curr Pharm Des 22(7):768–782. https://doi.org/10.2174/1381612822666151209151408

    Article  PubMed  CAS  Google Scholar 

  • Zhao CY, Frew JW, Muhaidat J, Cheung K, Lee P, Poulos V, McCrossin I, Cachia AR, Tefany F, Murrell DF (2016) Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation – a case series of four patients. J EADV 30(7):1239–1242. https://doi.org/10.1111/jdv.13168

    Article  CAS  Google Scholar 

  • Zink A, Ring J (2014) Phototoxic dermatitis. New Engl J Med 371(6):559–559. https://doi.org/10.1056/NEJMicm1315566

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Margarida Gonçalo .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Gonçalo, M. (2018). Phototoxic Dermatitis. In: John, S., Johansen, J., Rustemeyer, T., Elsner, P., Maibach, H. (eds) Kanerva’s Occupational Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-40221-5_15-2

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-40221-5_15-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40221-5

  • Online ISBN: 978-3-319-40221-5

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics