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Pain and Pain Management

Textbook of Palliative Care

Abstract

Pain is one of the commonest symptoms encountered in palliative medicine. Good pain management involves ensuring pain is screened for, adequately assessed if present and appropriately managed. This includes targeted and systemic, nonpharmacological, and pharmacological approaches. This chapter seeks to give an evidence-based overview of approaches to screening for assessing and managing a patient’s pain.

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References

  • Abbey J, Piller N, De Bellis A, Esterman A, Parker D, Giles L, Lowcay B. The Abbey pain scale: a 1-minute numerical indicator for people with end-stage dementia. Int J Palliat Nurs. 2004;10(1):6–13.

    Article  PubMed  Google Scholar 

  • Actavis. Product information fentanyl TD. 2012.

    Google Scholar 

  • Ale I, Lachapelle JM, Maibach HI. Skin tolerability associated with transdermal drug delivery systems: an overview. Adv Ther. 2009;26(10):920–35.

    Article  PubMed  CAS  Google Scholar 

  • ANZCA, FPM. Opioid calculator app. 2017. Retrieved 22nd January, 2017.

    Google Scholar 

  • Archie P, Bruera E, Cohen L. Music-based interventions in palliative cancer care: a review of quantitative studies and neurobiological literature. Support Care Cancer. 2013;21(9):2609–24.

    Article  PubMed  PubMed Central  Google Scholar 

  • Arcidiacono PG, Calori G, Carrara S, McNicol ED, Testoni PA. Celiac plexus block for pancreatic cancer pain in adults. Cochrane Database Syst Rev. 2011;3

    Google Scholar 

  • Australian Adult Cancer Pain Management Guideline Working Party. Cancer pain management in adults. Cancer guidelines wiki. Sydney, Cancer Council Australia; 2016.

    Google Scholar 

  • Ayonrinde OT, Bridge DT. The rediscovery of methadone for cancer pain management. Med J Aust. 2000;173:536–40.

    PubMed  CAS  Google Scholar 

  • Bandieri E, Romero M, Ripamonti CI, Artioli F, Sichetti D, Fanizza C, Santini D, Cavanna L, Melotti B, Conte PF, Roila F, Cascinu S, Bruera E, Tognoni G, Luppi M. Randomized trial of low-dose morphine versus weak opioids in moderate cancer pain. J Clin Oncol. 2015; 34(5):436–442.

    Article  PubMed  CAS  Google Scholar 

  • Bao Y, Kong X, Yang L, Liu R, Shi Z, Li W, Hua B, Hou W. Complementary and alternative medicine for cancer pain: an overview of systematic reviews. Evid Based Complement Alternat Med. 2014;2014(9):170396.

    PubMed  PubMed Central  Google Scholar 

  • Bell RF, Eccleston C, Kalso EA. Ketamine as an adjuvant to opioids for cancer pain. Cochrane Database Syst Rev. 2017;6:CD003351.

    PubMed  Google Scholar 

  • Bieri D, Reeve RA, Champion GD, Addicoat L, Ziegler JB. The faces pain scale for the self-assessment of the severity of pain experienced by children: development, initial validation, and preliminary investigation for ratio scale properties. Pain. 1990;41(2):139–50.

    Article  PubMed  CAS  Google Scholar 

  • BioCSL. Versartis product information. 2015.

    Google Scholar 

  • Boyd C, Crawford C, Paat CF, Price A, Xenakis L, Zhang W. The impact of massage therapy on function in pain populations – a systematic review and meta-analysis of randomized controlled trials: part II, cancer pain populations. Pain Med. 2016;17(8):1553–68. pnw100

    Article  PubMed  PubMed Central  Google Scholar 

  • Camilleri M. Opioid-induced constipation: challenges and therapeutic opportunities. Am J Gastroenterol. 2011;106(5):835–42.

    Article  PubMed  CAS  Google Scholar 

  • Caraceni A, Portenoy RK. An international survey of cancer pain characteristics and syndromes. Pain. 1999;82(3):263–74.

    Article  PubMed  CAS  Google Scholar 

  • Caraceni A, Pigni A, Brunelli C. Is oral morphine still the first choice opioid for moderate to severe cancer pain? A systematic review within the European palliative care research collaborative guidelines project. Palliat Med. 2011;25(5):402–9.

    Article  PubMed  Google Scholar 

  • Caraceni A, Hanks G, Kaasa S, Bennett MI, Brunelli C, Cherny N, Dale O, De Conno F, Fallon M, Hanna M, Haugen DF, Juhl G, King S, Klepstad P, Laugsand EA, Maltoni M, Mercadante S, Nabal M, Pigni A, Radbruch L, Reid C, Sjogren P, Stone PC, Tassinari D, Zeppetella G. Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC. Lancet Oncol. 2012;13(2):e58–68.

    Article  PubMed  CAS  Google Scholar 

  • Challapalli V, Tremont-Lukats IW, McNicol ED, Lau J, Carr DB. Systemic administration of local anesthetic agents to relieve neuropathic pain. Cochrane Database Syst Rev. 2005;4:CD003345.

    Google Scholar 

  • Chambers WA. Nerve blocks in palliative care. Br J Anaesth. 2008;101(1):95–100.

    Article  PubMed  CAS  Google Scholar 

  • Chow E, Meyer RM, Ding K, Nabid A, Chabot P, Wong P, Ahmed S, Kuk J, Dar AR, Mahmud A, Fairchild A, Wilson CF, Wu JSY, Dennis K, Brundage M, DeAngelis C, Wong RKS. Dexamethasone in the prophylaxis of radiation-induced pain flare after palliative radiotherapy for bone metastases: a double-blind, randomised placebo-controlled, phase 3 trial. Lancet Oncol. 2015;16(15):1463–72.

    Article  PubMed  CAS  Google Scholar 

  • Cleeland CS. The brief pain inventory user guide. M D Anderson Cancer Centre; 2009.

    Google Scholar 

  • Corrigan R, Derry S, Wiffen PJ, Moore RA. Clonazepam for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2012;(5).

    Google Scholar 

  • Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC. Clinical pharmacogenetics implementation consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014;95(4):376–82.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • da Costa BR, Reichenbach S, Keller N, Nartey L, Wandel S, Jüni P, Trelle S. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet. 2016;387(10033):2093–105.

    Article  PubMed  CAS  Google Scholar 

  • Dale O, Moksnes K, Kaasa S. European palliative care research collaborative pain guidelines: opioid switching to improve analgesia or reduce side effects. A systematic review. Palliat Med. 2011;25(5):494–503.

    Article  PubMed  Google Scholar 

  • Davis MP, Temel JS, Balboni T, Glare P. A review of the trials which examine early integration of outpatient and home palliative care for patients with serious illnesses. Ann Palliat Med. 2015;4(3):99–121.

    PubMed  Google Scholar 

  • de Courcy JG. Interventional techniques for cancer pain management. Clin Oncol (R Coll Radiol). 2011;23(6):407–17.

    Article  Google Scholar 

  • Deandrea S, Montanari M, Moja L, Apolone G. Prevalence of undertreatment in cancer pain. A review of published literature. Ann Oncol. 2008;19(12):1985–91.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Derry S, Phillips T, Moore RA, Wiffen PJ. Milnacipran for neuropathic pain in adults. Cochrane Database Syst Rev. 2015a;(7).

    Google Scholar 

  • Derry S, Wiffen PJ, Aldington D, Moore RA. Nortriptyline for neuropathic pain in adults. Cochrane Database Syst Rev. 2015b;(1).

    Google Scholar 

  • Derry S, Wiffen PJ, Moore RA, McNicol ED, Bell RF, Carr DB, McIntyre M, Wee B. Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults. Cochrane Database Syst Rev. 2017;7:CD012638.

    PubMed  Google Scholar 

  • Dong ST, Butow PN, Costa DSJ, Lovell MR, Agar M. Symptom clusters in patients with advanced cancer: a systematic review of observational studies. J Pain Symptom Manag. 2014;48(3):411–50.

    Article  Google Scholar 

  • Duehmke RM, Derry S, Wiffen PJ, Bell RF, Aldington D, Moore RA. Tramadol for neuropathic pain in adults. Cochrane Database Syst Rev. 2017;6:CD003726.

    PubMed  Google Scholar 

  • Eccleston C, Hearn L, Williams AC. Psychological therapies for the management of chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2015;10:CD011259.

    Google Scholar 

  • European Federation of Neurological Societies Task Force on Diagnosis and Management of Amyotrophic Lateral Sclerosis, Andersen PM, Abrahams S, Borasio GD, de Carvalho M, Chio A, Van Damme P, Hardiman O, Kollewe K, Morrison KE, Petri S, Pradat P-F, Silani V, Tomik B, Wasner M, Weber M. EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS) – revised report of an EFNS task force. Eur J Neurol. 2012;19(3):360–75.

    Google Scholar 

  • Fallon MT. Neuropathic pain in cancer. Br J Anaesth. 2013;111(1):105–11.

    Article  PubMed  CAS  Google Scholar 

  • Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, Gilron I, Haanpää M, Hansson P, Jensen TS, Kamerman PR, Lund K, Moore A, Raja SN, Rice ASC, Rowbotham M, Sena E, Siddall P, Smith BH, Wallace M. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015;14(2):162–73.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Fleming JAOC, B.D. Use of lidocaine patches for neuropathic pain in a comprehensive cancer Centre. Pain Res Manag. 2009;14(5):381–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • France BD, Lewis RA, Sharma ML, Poolman M. Cordotomy in mesothelioma-related pain: a systematic review. BMJ Support Palliat Care. 2014;4(1):19–29.

    Article  PubMed  Google Scholar 

  • Gallagher HC, Gallagher RM, Butler M, Buggy DJ, Henman MC. Venlafaxine for neuropathic pain in adults. Cochrane Database Syst Rev. 2015;(8).

    Google Scholar 

  • Garzon-Rodriguez C, Casals Merchan M, Calsina-Berna A, Lopez-Romboli E, Porta-Sales J. Lidocaine 5% patches as an effective short-term co-analgesic in cancer pain. Preliminary results. Support Care Cancer. 2013;21(11):3153–8.

    Article  PubMed  Google Scholar 

  • Gill D, Derry S, Wiffen PJ, Moore RA. Valproic acid and sodium valproate for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2011;(10).

    Google Scholar 

  • Grond S, Sablotzki A. Clinical pharmacology of tramadol. Clin Pharmacokinet. 2004;43(13):879–923.

    Article  PubMed  CAS  Google Scholar 

  • Hardy JR, Rees EAJ, Gwilliam B, Ling J, Broadley K, A’Hern R. A phase II study to establish the efficacy and toxicity of sodium valproate in patients with cancer-related neuropathic pain. J Pain Symptom Manag. 2001;21(3):204–9.

    Article  CAS  Google Scholar 

  • Hadley G, Derry S, Moore RA, Wiffen PJ. Transdermal fentanyl for cancer pain. Cochrane Database Syst Rev. 2013;10:CD010270.

    Google Scholar 

  • Hans G, Robert D. Transdermal buprenorphine – a critical appraisal of its role in pain management. J Pain Res. 2009;2:117–34.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Haraldsplass Deaconess Hospital. Paracetamol for cancer pain trial. From https://clinicaltrials.gov/ct2/show/NCT01313247?term=paracetamol%2C+pain%2C+cancer&rank=2

  • Haywood A, Good P, Khan S, Leupp A, Jenkins-Marsh S, Rickett K, Hardy JR. Corticosteroids for the management of cancer-related pain in adults. Cochrane Database Syst Rev. 2015;4:CD010756.

    Google Scholar 

  • Hearn L, Derry S, Moore RA. Lacosamide for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2012;(2).

    Google Scholar 

  • Hearn L, Derry S, Phillips T, Moore RA, Wiffen PJ. Imipramine for neuropathic pain in adults. Cochrane Database Syst Rev. 2014a;(5).

    Google Scholar 

  • Hearn L, Moore RA, Derry S, Wiffen PJ, Phillips T. Desipramine for neuropathic pain in adults. Cochrane Database Syst Rev. 2014b;(9).

    Google Scholar 

  • Hebert D, Lindsay MP, McIntyre A, Kirton A, Rumney PG, Bagg S, Bayley M, Dowlatshahi D, Dukelow S, Garnhum M, Glasser E, Halabi M-L, Kang E, MacKay-Lyons M, Martino R, Rochette A, Rowe S, Salbach N, Semenko B, Stack B, Swinton L, Weber V, Mayer M, Verrilli S, DeVeber G, Andersen J, Barlow K, Cassidy C, Dilenge M-E, Fehlings D, Hung R, Iruthayarajah J, Lenz L, Majnemer A, Purtzki J, Rafay M, Sonnenberg LK, Townley A, Janzen S, Foley N, Teasell R. Canadian stroke best practice recommendations: stroke rehabilitation practice guidelines, update 2015. Int J Stroke. 2016;11(4):459–84.

    Article  PubMed  Google Scholar 

  • Heiskanen T, Matzke S, Haakana S, Gergov M, Vuori E, Kalso E. Transdermal fentanyl in cachectic cancer patients. Pain. 2009;144(1–2):218–22.

    Article  PubMed  CAS  Google Scholar 

  • Horneber M, Bueschel G, Dennert G, Less D, Ritter E, Zwahlen M. How many cancer patients use complementary and alternative medicine: a systematic review and Metaanalysis. Integr Cancer Ther. 2012;11(3):187–203.

    Article  PubMed  Google Scholar 

  • Hunt SP, Mantyh PW. The molecular dynamics of pain control. Nat Rev Neurosci. 2001;2:83.

    Article  PubMed  CAS  Google Scholar 

  • Hurlow A, Bennett MI, Robb KA, Johnson MI, Simpson KH, Oxberry SG. Transcutaneous electric nerve stimulation (TENS) for cancer pain in adults. Cochrane Database Syst Rev. 2012;3:CD006276.

    Google Scholar 

  • International Association for the Study of Pain. Total cancer pain. 2009.

    Google Scholar 

  • International Association for the Study of Pain. IASP taxonomy.2017. Retrieved 19 Nov 2017, from https://www.iasp-pain.org/Taxonomy?navItemNumber=576

  • Jarupongprapa S, Ussavasodhi P, Katchamart W. Comparison of gastrointestinal adverse effects between cyclooxygenase-2 inhibitors and non-selective, non-steroidal anti-inflammatory drugs plus proton pump inhibitors: a systematic review and meta-analysis. J Gastroenterol. 2013;48(7):830–8.

    Article  PubMed  CAS  Google Scholar 

  • Johnson MI, Mulvey MR, Bagnall A-M. Transcutaneous electrical nerve stimulation (TENS) for phantom pain and stump pain following amputation in adults. Cochrane Database Syst Rev. 2015a;8:CD007264.

    PubMed  Google Scholar 

  • Johnson MI, Paley CA, Howe TE, Sluka KA. Transcutaneous electrical nerve stimulation for acute pain. Cochrane Database Syst Rev. 2015b;6:CD006142.

    Google Scholar 

  • Jordan RI, Mulvey MR, Bennett MI. A critical appraisal of gabapentinoids for pain in cancer patients. Curr Opin Support Palliat Care. 2018;12(2):108–17.

    PubMed  Google Scholar 

  • King S, Forbes K, Hanks G, Ferro C, Chambers E. A systematic review of the use of opioid medication for those with moderate to severe cancer pain and renal impairment: a European palliative care research collaborative opioid guidelines project. Palliat Med. 2011;25(5):525–52.

    Article  PubMed  CAS  Google Scholar 

  • Kjellberg F, Tramèr MR. Pharmacological control of opioid-induced pruritus: a quantitative systematic review of randomized trials. Eur J Anaesthesiol. 2001;18:346–57.

    Article  PubMed  CAS  Google Scholar 

  • Klepstad P, Kaasa S, Borchgrevink PC. Starting step III opioids for moderate to severe pain in cancer patients: dose titration: a systematic review. Palliat Med. 2011;25(5):424–30.

    Article  PubMed  Google Scholar 

  • Kane CM, Mulvey MR, Wright S, Craigs C, Wright JM, Bennett MI. Opioids combined with antidepressants or antiepileptic drugs for cancer pain: systematic review and meta-analysis. Palliat Med. 2017;32(1):276–86.

    Article  PubMed  Google Scholar 

  • Kress HG. Clinical update on the pharmacology, efficacy and safety of transdermal buprenorphine. Eur J Pain. 2009;13(3):219–30.

    Article  PubMed  CAS  Google Scholar 

  • Laugsand EA, Kaasa S, Klepstad P. Management of opioid-induced nausea and vomiting in cancer patients: systematic review and evidence-based recommendations. Palliat Med. 2011;25(5):442–53.

    Article  PubMed  Google Scholar 

  • Leppert W. The role of methadone in cancer pain treatment – a review. Int J Clin Pract. 2009;63(7):1095–109.

    Article  PubMed  CAS  Google Scholar 

  • Lickiss JN. Approaching cancer pain relief. Eur J Pain. 2001;5(Suppl A):5–14.

    Article  PubMed  CAS  Google Scholar 

  • Løhre ET, Klepstad P, Bennett MI, Brunelli C, Caraceni A, Fainsinger RL, Knudsen AK, Mercadante S, Sjøgren P, Kaasa S. From “breakthrough” to “episodic” cancer pain? A European Association for palliative care research network expert Delphi survey toward a common terminology and classification of transient cancer pain exacerbations. J Pain Symptom Manag. 2016;51(6):1013–9.

    Article  Google Scholar 

  • Lunn MPT, Hughes RAC, Wiffen PJ. Duloxetine for treating painful neuropathy, chronic pain or fibromyalgia. Cochrane Database Syst Rev. 2014;(1).

    Google Scholar 

  • Lynn TRD, Smith HS, Burton AW, Pope JE, Doleys DM, Levy RM, Staats PS, Wallace M. Comprehensive consensus based guidelines on intrathecal drug delivery systems in the treatment of pain caused by cancer pain. Pain Physician. 2011;14:E283–312.

    Google Scholar 

  • Marie N, Luckett T, Davidson PM, Lovell M, Lal S. Optimal patient education for cancer pain: a systematic review and theory-based meta-analysis. Support Care Cancer. 2013;21(12):3529–37.

    Article  PubMed  CAS  Google Scholar 

  • McConnell T, Scott D, Porter S. Music therapy for end-of-life care: an updated systematic review. Palliat Med. 2016;30:877–83.

    Article  PubMed  Google Scholar 

  • McLean S, Twomey F. Methods of rotation from another strong opioid to methadone for the management of cancer pain: a systematic review of the available evidence. J Pain Symptom Manag. 2015;50(2):248–59. e241

    Article  Google Scholar 

  • McNicol ED, Midbari A, Eisenberg E. Opioids for neuropathic pain. Cochrane Database Syst Rev. 2013;(8).

    Google Scholar 

  • McNicol ED, Midbari A, Eisenberg E. Opioids for neuropathic pain. Cochrane Database Syst Rev. 2013;8:CD008025.

    Google Scholar 

  • McNicol ED, Ferguson MC, Schumann R. Methadone for neuropathic pain in adults. Cochrane Database Syst Rev. 2017;5:CD012499.

    PubMed  Google Scholar 

  • MD Anderson Cancer Center and Cancer Clinical Trials. Methadone, morphine, or oxycodone in treating pain in patients with cancer. From https://clinicaltrials.gov/ct2/show/NCT00726830?term=paracetamol%2C+pain%2C+cancer&rank=18

  • Meier T, Wasner G, Faust M, Kuntzer T, Ochsner F, Hueppe M, Bogousslavsky J, Baron R. Efficacy of lidocaine patch 5% in the treatment of focal peripheral neuropathic pain syndromes: a randomized, double-blind, placebo-controlled study. Pain. 2003;106(1):151–8.

    Article  PubMed  CAS  Google Scholar 

  • Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150(3699):971–9.

    Article  PubMed  CAS  Google Scholar 

  • Mercadante S, Caraceni A. Conversion ratios for opioid switching in the treatment of cancer pain: a systematic review. Palliat Med. 2011;25(5):504–15.

    Article  PubMed  Google Scholar 

  • Mercadante S, Arcuri E, Tirelli W, Casuccio A. Analgesic effect of intravenous ketamine in cancer patients on morphine therapy: a randomized, controlled, double-blind, crossover, double-dose study. J Pain Symptom Manag. 2000;20(4):246–52.

    Article  CAS  Google Scholar 

  • Mercadante S, Porzio G, Aielli F, Adile C, Verna L, Ficorella C, Giarratano A, Casuccio A. Opioid switching from and to tapentadol extended release in cancer patients: conversion ratio with other opioids. Curr Med Res Opin. 2013;29(6):661–6.

    Article  PubMed  CAS  Google Scholar 

  • Mercadante S, Klepstad P, Kurita GP, Sjogren P, Giarratano A, European Palliative Care Research Centre. Sympathetic blocks for visceral cancer pain management: a systematic review and EAPC recommendations. Crit Rev Oncol Hematol. 2015;96(3):577–83.

    Article  PubMed  Google Scholar 

  • Mhaskar R, Redzepovic J, Wheatley K, Clark OAC, Miladinovic B, Glasmacher A, Kumar A, Djulbegovic B. Bisphosphonates in multiple myeloma: a network meta-analysis. Cochrane Database Syst Rev. 2012;5:CD003188.

    Google Scholar 

  • Miller JL, Hagemann TM. Use of pure opioid antagonists for management of opioid-induced pruritus. Am J Health Syst Pharm. 2011;68(15):1419–25.

    Article  PubMed  CAS  Google Scholar 

  • Mitchell AJ. Are one or two simple questions sufficient to detect depression in cancer and palliative care? A Bayesian meta-analysis. Br J Cancer. 2008;98(12):1934–43.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Moore RA, Straube S, Wiffen PJ, Derry S, McQuay HJ. Pregabalin for acute and chronic pain in adults. Cochrane Database Syst Rev. 2009;(3).

    Google Scholar 

  • Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ. Amitriptyline for neuropathic pain in adults. Cochrane Database Syst Rev. 2015a;(7).

    Google Scholar 

  • Moore RA, Wiffen PJ, Derry S, Lunn MPT. Zonisamide for neuropathic pain in adults. Cochrane Database Syst Rev. 2015b;(1).

    Google Scholar 

  • National Clinical Effectiveness Committee. Pharmacological management of cancer pain in adults. 2015.

    Google Scholar 

  • National Clinical Effectiveness Committee. Pharmacological management of cancer pain in adults. 2016.

    Google Scholar 

  • National Comprehensive Cancer Network. Adult cancer pain. 2016.

    Google Scholar 

  • NICE. Neuropathic pain in adults: pharmacological management in non-specialist settings. 2013.

    Google Scholar 

  • NCE Committee. Pharmacological management of cancer pain in adults. 2016.

    Google Scholar 

  • Nicholson AB, Watson GR, Derry S, Wiffen PJ. Methadone for cancer pain. Cochrane Database Syst Rev. 2017;2:CD003971.

    PubMed  Google Scholar 

  • O’Carrigan B, Wong MHF, Willson ML, Stockler MR, Pavlakis N, Goodwin A. Bisphosphonates and other bone agents for breast cancer. Cochrane Database Syst Rev. 2017;10:CD003474.

    PubMed  Google Scholar 

  • Oosten AW, Oldenmenger WH, Mathijssen RH, van der Rijt CC. A systematic review of prospective studies reporting adverse events of commonly used opioids for cancer-related pain: a call for the use of standardized outcome measures. J Pain. 2015;16(10):935–46.

    Article  PubMed  Google Scholar 

  • Paley CA, Johnson MI, Tashani OA, Bagnall A-M. Acupuncture for cancer pain in adults. Cochrane Database Syst Rev. 2015;10:CD007753.

    Google Scholar 

  • Pasternak GW. Opioids and their receptors: are we there yet? Neuropharmacology. 2014;76, Part B:198–203.

    Article  CAS  Google Scholar 

  • Paulsen O, Aass N, Kaasa S, Dale O. Do corticosteroids provide analgesic effects in cancer patients? A systematic literature review. J Pain Symptom Manag. 2013;46(1):96–105.

    Article  CAS  Google Scholar 

  • Paulsen O, Klepstad P, Rosland JH, Aass N, Albert E, Fayers P, Kaasa S. Efficacy of methylprednisolone on pain, fatigue, and appetite loss in patients with advanced cancer using opioids: a randomized, placebo-controlled, double-blind trial. J Clin Oncol. 2014;32(29):3221–8.

    Article  PubMed  CAS  Google Scholar 

  • Peixoto RDA, Hawley P. Intravenous lidocaine for cancer pain without electrocardiographic monitoring: a retrospective review. J Palliat Med. 2014;18(4):373–7.

    Article  PubMed  Google Scholar 

  • Peng L, Min S, Zejun Z, Wei K, Bennett MI. Spinal cord stimulation for cancer-related pain in adults. Cochrane Database Syst Rev. 2015;6:CD009389.

    Google Scholar 

  • Porta-Sales J, Garzon-Rodriguez C, Llorens-Torrome S, Brunelli C, Pigni A, Caraceni A. Evidence on the analgesic role of bisphosphonates and denosumab in the treatment of pain due to bone metastases: a systematic review within the European Association for palliative care guidelines project. Palliat Med. 2017;31(1):5–25.

    Article  PubMed  Google Scholar 

  • Portenoy RK, Ahmed E. Principles of opioid use in cancer pain. J Clin Oncol. 2014;32(16):1662–70.

    Article  PubMed  CAS  Google Scholar 

  • Prommer EE. Ketamine for pain: an update of uses in palliative care. J Palliat Med. 2012;15(4):474–83.

    Article  PubMed  Google Scholar 

  • Pruskowski J, Arnold RM. A comparison of pregabalin and gabapentin in palliative care #289. J Palliat Med. 2015;18(4):386–7.

    Article  PubMed  Google Scholar 

  • Puchalski C, Ferrell B, Virani R, Otis-Green S, Baird P, Bull J, Chochinov H, Handzo G, Nelson-Becker H, Prince-Paul M, Pugliese K, Sulmasy D. Improving the quality of spiritual care as a dimension of palliative care: the report of the consensus conference. J Palliat Med. 2009;12(10):885–904.

    Article  PubMed  Google Scholar 

  • Rayment C, Hjermstad MJ, Aass N, Kaasa S, Caraceni A, Strasser F, Heitzer E, Fainsinger R, Bennett MI, Collaborative O b o t EPCR. Neuropathic cancer pain: prevalence, severity, analgesics and impact from the European Palliative Care Research Collaborative–Computerised Symptom Assessment study. Palliat Med. 2013;27(8):714–21.

    Article  PubMed  Google Scholar 

  • Reich A, Szepietowski JC. Opioid-induced pruritus: an update. Clin Exp Dermatol. 2010;35(1):2–6.

    Article  PubMed  CAS  Google Scholar 

  • Royal Australian College of General Practitioners. Pharmaceutical Society of Australia. Australian Medicines Handbook. 2016.

    Google Scholar 

  • Rueda J-R, Solà I, Pascual A, Subirana Casacuberta M. Non-invasive interventions for improving well-being and quality of life in patients with lung cancer. Cochrane Database Syst Rev. 2011;9:CD004282.

    Google Scholar 

  • Salas S, Frasca M, Planchet-Barraud B, Burucoa B, Pascal M, Lapiana JM, Hermet R, Castany C, Ravallec F, Loundou A, Auquier P, Duffaud F, Baumstarck K. Ketamine analgesic effect by continuous intravenous infusion in refractory cancer pain: considerations about the clinical research in palliative care. J Palliat Med. 2012;15(3):287–93.

    Article  PubMed  Google Scholar 

  • Sande TA, Laird BJ, Fallon MT. The use of opioids in cancer patients with renal impairment-a systematic review. Support Care Cancer. 2017;25(2):661–75.

    Article  PubMed  Google Scholar 

  • Schmidt-Hansen M, Bromham N, Taubert M, Arnold S, Hilgart JS. Buprenorphine for treating cancer pain. Cochrane Database Syst Rev. 2015;3:CD009596.

    Google Scholar 

  • Schmidt-Hansen M, Bennett MI, Arnold S, Bromham N, Hilgart JS. Oxycodone for cancer-related pain. Cochrane Database Syst Rev. 2017;8:CD003870.

    PubMed  Google Scholar 

  • Schug SA, Palmer G, Sco DA, Halliwell R, Trinca J. APM:SE working group of the Australian and New Zealand college of Anaesthetists and Faculty of Pain Medicine. Melbourne: ANZCA and FPM; 2015.

    Google Scholar 

  • Scottish Intercollegiate Guidelines Network. Control of pain in adults with cancer. Scottish Intercollegiate Guidelines Network: Edinburgh; 2008.

    Google Scholar 

  • Scottish Partnership for Palliative Care. Scottish palliative care guidelines. 2013, 2016. Retrieved 22 Jan 2017, from http://www.palliativecareguidelines.scot.nhs.uk/

  • Seah DS, Herschtal A, Tran H, Thakerar A, Fullerton S. Subcutaneous lidocaine infusion for pain in patients with cancer. J Palliat Med. 2016; 20(6):667–71.

    Article  PubMed  Google Scholar 

  • Shaiova L, Berger A, Blinderman CD, Bruera E, Davis MP, Derby S, Inturrisi C, Kalman J, Mehta D, Pappagallo M, Perlov E. Consensus guideline on parenteral methadone use in pain and palliative care. Palliat Support Care. 2008;6(2):165–76.

    Article  PubMed  Google Scholar 

  • Sharma S, Rajagopal MR, Palat G, Singh C, Haji AG, Jain D. A phase II pilot study to evaluate use of intravenous lidocaine for opioid-refractory pain in cancer patients. J Pain Symptom Manag. 2009;37(1):85–93.

    Article  CAS  Google Scholar 

  • Sheinfeld Gorin S, Krebs P, Badr H, Janke EA, Jim HSL, Spring B, Mohr DC, Berendsen MA, Jacobsen PB. Meta-analysis of psychosocial interventions to reduce pain in patients with cancer. J Clin Oncol. 2012;30(5):539–47.

    Article  PubMed  PubMed Central  Google Scholar 

  • Shepherd TM, Hoch MJ, Cohen BA, Bruno MT, Fieremans E, Rosen G, Pacione D, Mogilner AY. Palliative CT-guided Cordotomy for medically intractable pain in patients with cancer. AJNR Am J Neuroradiol. 2017;38(2):387–90.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Shin E-S, Seo K-H, Lee S-H, Jang J-E, Jung Y-M, Kim M-J, Yeon J-Y. Massage with or without aromatherapy for symptom relief in people with cancer. Cochrane Database Syst Rev. 2016;6:CD009873.

    Google Scholar 

  • Solano JP, Gomes B, Higginson IJ. A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manag. 2006;31(1):58–69.

    Article  Google Scholar 

  • Sperlinga R, Campagna S, Berruti A, Laciura P, Ginosa I, Paoletti S, Giuliano PL, Tucci M, Rosato R, Scagliotti GV, Saini A. Alberta breakthrough pain assessment tool: a validation multicentre study in cancer patients with breakthrough pain. Eur J Pain. 2015;19(7):881–8.

    Article  PubMed  CAS  Google Scholar 

  • Stannard C, Gaskell H, Derry S, Aldington D, Cole P, Cooper TE, Knaggs R, Wiffen PJ, Moore RA. Hydromorphone for neuropathic pain in adults. Cochrane Database Syst Rev. 2016;5:CD011604.

    Google Scholar 

  • Straube C, Derry S, Jackson KC, Wiffen PJ, Bell RF, Strassels S, Straube S. Codeine, alone and with paracetamol (acetaminophen), for cancer pain. Cochrane Database Syst Rev. 2014;9:CD006601.

    Google Scholar 

  • Syrmis W, Good P, Wootton J, Spurling G. Opioid conversion ratios used in palliative care: is there an Australian consensus? Intern Med J. 2014;44(5):483–9.

    Article  PubMed  CAS  Google Scholar 

  • Tassinari D, Drudi F, Rosati M, Tombesi P, Sartori S, Maltoni M. The second step of the analgesic ladder and oral tramadol in the treatment of mild to moderate cancer pain: a systematic review. Palliat Med. 2011;25(5):410–23.

    Article  PubMed  Google Scholar 

  • Tatrow K, Montgomery GH. Cognitive behavioral therapy techniques for distress and pain in breast cancer patients: a meta-analysis. J Behav Med. 2006;29(1):17–27.

    Article  PubMed  Google Scholar 

  • The International Association for the Study of Pain and Taxonomy Working Group. Pain terms. Classification of chronic pain, Second Edition (Revised). Washington, DC; 2011. https://www.iasp-pain.org/Taxonomy?navItemNumber=576

  • Thomas J, Kronenberg R, Cox MC, Naco GC, Wallace M, Gunten CF v. Intravenous lidocaine relieves severe pain: results of an inpatient hospice chart review. J Palliat Med. 2004;7(5):660–7.

    Article  PubMed  Google Scholar 

  • Twycross R; Wilcock A; Howard P; Palliative care formulary 5th Edition. 2016.

    Google Scholar 

  • Tyson SF, Kent RM. The effect of upper limb orthotics after stroke: a systematic review. NeuroRehabilitation. 2011;28(1):29–36.

    PubMed  Google Scholar 

  • University Health Network Toronto. Acetaminophen for cancer pain trial. From https://clinicaltrials.gov/ct2/show/NCT00152854?term=paracetamol%2C+pain%2C+cancer&rank=1

  • University of Edinburgh Trial. Paracetamol versus placebo in conjunction with strong opioids for cancer pain (PaSO) Trial. From https://clinicaltrials.gov/ct2/show/NCT02706769?term=paracetamol%2C+pain%2C+cancer&rank=6

  • University of Edinburgh Trial. Two step versus the standard three step approach of the WHO analgesic ladder for cancer pain relief. (TVT) Trial.

    Google Scholar 

  • University of Florida Trial. Precision medicine guided treatment for cancer pain Trial.

    Google Scholar 

  • Upadhyay SP, Mallick PN. Intrathecal drug delivery system (IDDS) for cancer pain management: a review and updates. Am J Hosp Palliat Care. 2012;29(5):388–98.

    Article  PubMed  Google Scholar 

  • van den Beuken-van Everdingen MHJ, Hochstenbach LMJ, Joosten EAJ, Tjan-Heijnen VCG, Janssen DJA. Update on prevalence of pain in patients with cancer: systematic review and meta-analysis. J Pain Symptom Manag. 2016;51(6):1070–90. e1079

    Article  Google Scholar 

  • Vellucci R, Fanelli G, Pannuti R, Peruselli C, Adamo S, Alongi G, Amato F, Consoletti L, Lamarca L, Liguori S, Lo Presti C, Maione A, Mameli S, Marinangeli F, Marulli S, Minotti V, Miotti D, Montanari L, Moruzzi G, Palermo S, Parolini M, Poli P, Tirelli W, Valle A, Romualdi P. What to do, and what not to do, when diagnosing and treating breakthrough cancer pain (BTcP): expert opinion. Drugs. 2016;76(3):315–30.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ventafridda V, Caraceni A, Gamba A. Field-testing of the WHO guidelines for cancer pain relief-summary report of demonstration projects. Adv Pain Res Ther. 1990;16:451–64.

    Google Scholar 

  • Webber K, Davies AN, Zeppetella G, Cowie MR. Development and validation of the breakthrough pain assessment tool (BAT) in cancer patients. J Pain Symptom Manag. 2014;48(4):619–31.

    Article  Google Scholar 

  • Wen W, Lynch SY, Munera C, Swanton R, Ripa SR, Maibach H. Application site adverse events associated with the buprenorphine transdermal system: a pooled analysis. Expert Opin Drug Saf. 2013;12(3):309–19.

    Article  PubMed  CAS  Google Scholar 

  • Wiffen PJ, Derry S, Lunn MPT, Moore RA. Topiramate for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2013a;(8).

    Google Scholar 

  • Wiffen PJ, Derry S, Moore RA, Aldington D, Cole P, Rice ASC, Lunn MPT, Hamunen K, Haanpaa M, Kalso EA. Antiepileptic drugs for neuropathic pain and fibromyalgia – an overview of Cochrane reviews. Cochrane Database Syst Rev. 2013b;(11).

    Google Scholar 

  • Wiffen PJ, Derry S, Moore RA, Kalso EA. Carbamazepine for chronic neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2014a;(4).

    Google Scholar 

  • Wiffen PJ, Derry S, Moore RA, Lunn MPT. Levetiracetam for neuropathic pain in adults. Cochrane Database Syst Rev. 2014b;(7).

    Google Scholar 

  • Wiffen PJ, Derry S, Moore RA, Stannard C, Aldington D, Cole P, Knaggs R. Buprenorphine for neuropathic pain in adults. Cochrane Database Syst Rev. 2015a;9:CD011603.

    Google Scholar 

  • Wiffen PJ, Derry S, Naessens K, Bell RF. Oral tapentadol for cancer pain. Cochrane Database Syst Rev. 2015b;9:CD011460.

    Google Scholar 

  • Wiffen PJ, Knaggs R, Derry S, Cole P, Phillips T, Moore RA. Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults. Cochrane Database Syst Rev. 2016a;12:CD012227.

    PubMed  Google Scholar 

  • Wiffen PJ, Wee B, Moore RA. Oral morphine for cancer pain. Cochrane Database Syst Rev. 2016b;4:CD003868.

    PubMed  Google Scholar 

  • Wiffen PJ, Derry S, Moore RA. Tramadol with or without paracetamol (acetaminophen) for cancer pain. Cochrane Database Syst Rev. 2017a;5:CD012508.

    PubMed  Google Scholar 

  • Wiffen PJ, Derry S, Moore RA, McNicol ED, Bell RF, Carr DB, McIntyre M, Wee B. Oral paracetamol (acetaminophen) for cancer pain. Cochrane Database Syst Rev. 2017b;7:CD012637.

    PubMed  Google Scholar 

  • Wong RKS, Wiffen PJ. Bisphosphonates for the relief of pain secondary to bone metastases. Cochrane Database Syst Rev. 2002;2:CD002068.

    Google Scholar 

  • Wong MHF, Stockler MR, Pavlakis N. Bisphosphonates and other bone agents for breast cancer. Cochrane Database Syst Rev. 2012;2:CD003474.

    Google Scholar 

  • World Health Organisation. Traitement de la doleur cancereuse. Geneva: World Health Organisation; 1987.

    Google Scholar 

  • World Health Organisation. Cancer pain relief. Geneva: World Health Organisation; 1996.

    Google Scholar 

  • World Health Organisation. Definition of palliative care. 2016. From http://www.who.int/cancer/palliative/definition/en/

  • Zeppetella G. Opioids for the management of breakthrough cancer pain in adults: a systematic review undertaken as part of an EPCRC opioid guidelines project. Palliat Med. 2011;25(5):516–24.

    Article  PubMed  Google Scholar 

  • Zeppetella G, Davies AN. Opioids for the management of breakthrough pain in cancer patients. Cochrane Database Syst Rev. 2015;8:CD004311.

    Google Scholar 

  • Zhou M, Chen N, He L, Yang M, Zhu C, Wu F. Oxcarbazepine for neuropathic pain. Cochrane Database Syst Rev. 2013;(3).

    Google Scholar 

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Franklin, A.E., Lovell, M.R. (2018). Pain and Pain Management. In: MacLeod, R., Van den Block, L. (eds) Textbook of Palliative Care. Springer, Cham. https://doi.org/10.1007/978-3-319-31738-0_10-1

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  1. Latest

    Pain and Pain Management
    Published:
    12 June 2018

    DOI: https://doi.org/10.1007/978-3-319-31738-0_10-2

  2. Original

    Pain and Pain Management
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    19 February 2018

    DOI: https://doi.org/10.1007/978-3-319-31738-0_10-1