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Neonatology pp 1561–1573Cite as

Recombinant G-CSF Treatment of Severe Chronic Neutropenia in Neonates and Infants

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Abstract

Neutropenia is a condition characterized by a diminution in the number of circulating neutrophils and increases susceptibility to local and systemic infections. Neutropenia can be a transient and benign condition, in which there is no need of specific therapy, except for intercurrent situations, such as antibiotic therapy in infections. Alternatively, it can be part of a more complex and severe situation, associated with other organ dysfunctions or malformations. Severe chronic neutropenia is a group of diagnoses characterized by hyporegenerative neutropenia, generally present from birth; these newborns and children often need the administration of recombinant granulocyte colony-stimulating factor (rG-CSF). The advent of rG-CSF dramatically improved the lives of these patients, elevating their circulating neutrophil concentrations, markedly reducing infectious illnesses, and extending life expectancy. When a transient variety of neonatal neutropenia is diagnosed, distinct from severe chronic neutropenia (SCN), the benefit of rG-CSF treatment is unproven and of dubious value.

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Authors and Affiliations

  1. Divisions of Neonatology and Hematology, Department of Pediatrics, University of Utah School of Medicine, Intermountain Healthcare, Salt Lake City, UT, USA

    Robert D. Christensen

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  1. Robert D. Christensen
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Correspondence to Robert D. Christensen .

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Editors and Affiliations

  1. Department of Pediatrics Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy

    Giuseppe Buonocore

  2. Department of Pediatrics Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy

    Rodolfo Bracci

  3. Liverpool Women’s Hospital Neonatal Unit, Liverpool, UK

    Michael Weindling

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Christensen, R.D. (2018). Recombinant G-CSF Treatment of Severe Chronic Neutropenia in Neonates and Infants. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Cham. https://doi.org/10.1007/978-3-319-29489-6_245

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  • DOI: https://doi.org/10.1007/978-3-319-29489-6_245

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