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Esophageal Atresia of Newborns

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Abstract

Esophageal atresia includes a group of congenital anomalies characterized as interruption of the continuity of the esophagus combined with or without a persistent communication with the trachea. These congenital malformations occur in 1:2,500–3,000 live births.

Over the last 40 years, there has been a steady improvement in the overall survival rate due to early diagnosis and prompt referral, improvements in preoperative care and diagnosis and treatment of associated anomalies, advances in anesthetic techniques, and sophisticated neonatal intensive care.

There is increasing experience with the thoracoscopic approach to repair esophageal atresia (Brandigi et al., J Siena Acad Sci 5, 2013; Bax and van Der Zee, J Pediatr Surg 37: 192–196, 2002; Rothenberg, J Pediatr Surg 37: 869–872, 2002; Nguyen et al., J Laparoendosc Adv Surg Tech A 16: 174–178, 2006; Krosnar and Baxter, Paediatr Anaesth 15: 541–546, 2005; Rothenberg, Semin Pediatr Surg 14: 2–7, 2005a; Rothenberg, Esophageal atresia and tracheoesophageal fistula. In: Najmaldin et al. (eds) Operative endoscopy and endoscopic surgery in infants and children. Hodder Arnold, London, pp 89–97, 2005b), but this requires advanced skills in minimal invasive surgery.

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References

  • Agrawal L, Beardsmore CS, MacFadyen UM (1999) Respiratory function in childhood following repair of oesophageal atresia and tracheoesophageal fistula. Arch Dis Child 81:404–408

    Article  CAS  Google Scholar 

  • Babu R, Pierro A, Spitz L et al (2000) The management of esophageal atresia in neonates with right-sided aortic arch. J Pediatr Surg 35:56–58

    Article  CAS  Google Scholar 

  • Bax KM, van Der Zee DC (2002) Feasibility of thoracoscopic repair of esophageal atresia with distal fistula. J Pediatr Surg 37:192–196

    Article  Google Scholar 

  • Bax NM, van der Zee DC (2007) Jejunal pedicle grafts for reconstruction of the esophagus in children. J Pediatr Surg 42:363–369

    Article  CAS  Google Scholar 

  • Bianchi A, Sowande O, Alizai NK, Rampersad B (1998) Aesthetics and lateral thoracotomy in the neonate. J Pediatr Surg 33:1798–1800

    Article  CAS  Google Scholar 

  • Brandigi E, Molinaro F et al (2013) Thoracoscopic repair of esophageal atresia with distal fistula in a new born: a technical case report. J Siena Acad Sci 5. Published Since 1761:85–88

    Article  Google Scholar 

  • Chittmittrapap S, Spitz L, Kiely EM, Brereton RJ (1980) Esophageal atresia and associated anomalies. Arch Dis Child 64:364–368

    Article  Google Scholar 

  • Cloud DT (1968) Anastomotic technique in esophageal atresia. J Pediatr Surg 3:561–564

    Article  CAS  Google Scholar 

  • Corbally MT, Spitz L, Kiely E et al (1993) Aortopexy for tracheomalacia in oesophageal anomalies. Eur J Pediatr Surg 3:264–266

    Article  CAS  Google Scholar 

  • Crisera CA, Connelly PR, Marmureanu AR et al (1999) Esophageal atresia with tracheoesophageal fistula: suggested mechanism in faulty organogenesis. J Pediatr Surg 34:204–208

    Article  CAS  Google Scholar 

  • Digilio MC, Marino B, Bagolan P et al (1999) Microdeletion 22q11 and esophageal atresia. J Med Genet 36:137–139

    CAS  PubMed  PubMed Central  Google Scholar 

  • Driver CP, Shankar KR, Jones MO et al (2001) Phenotypic presentation and outcome of esophageal atresia in the era of the Spitz classification. J Pediatr Surg 36:1419–1421

    Article  CAS  Google Scholar 

  • Duranceau A, Fisher SR, Flye M (1977) Motor function of the esophagus after repair of esophageal atresia and tracheoesophageal fistula. Surgery 82:116–123

    CAS  PubMed  Google Scholar 

  • Filler RM, Messineo A, Vinograd L (1992) Severe tracheomalacia associated with esophageal atresia: results of surgical treatment. J Pediatr Surg 27:1136–1140

    Article  CAS  Google Scholar 

  • Filston HC, Chitwood WR Jr, Schkolne B, Blackmon LR (1982a) The Fogarty balloon catheter as an aid to management of the infant with esophageal atresia and tracheoesophageal fistula complicated by severe RDS or pneumonia. J Pediatr Surg 17:149–151

    Article  CAS  Google Scholar 

  • Filston HC, Rankin JS, Kirks DR (1982b) The diagnosis of primary and recurrent tracheoesophageal fistulas: value of selective catheterization. J Pediatr Surg 17:144–148

    Article  CAS  Google Scholar 

  • Hagberg S, Rubcnson A, Sillcn U, Werkmaster K (1986) Management of long-gap esophagus: experience with end-to-end anastomosis under maximal tension. Prog Pediatr Surg 19:88–92

    Article  CAS  Google Scholar 

  • Holmes SJK, Kiely EM, Spitz L (1987) Tracheoesophageal fistula and the respiratory distress syndrome. Pediatr Surg Int 2:16–18

    Article  Google Scholar 

  • Kluth D (1976) Atlas of esophageal atresia. J Pediatr Surg 11:901–919

    Article  CAS  Google Scholar 

  • Krosnar S, Baxter A (2005) Thoracoscopic repair of esophageal atresia with tracheoesophageal fistula: anesthetic and intensive care management of a series of eight neonates. Paediatr Anaesth 15:541–546

    Article  Google Scholar 

  • Langer JC, Hussain H, Khan A et al (2001) prenatal diagnosis of esophageal atresia using sonography and magnetic resonance imaging. J Pediatr Surg 36:804–807

    Article  CAS  Google Scholar 

  • Litingtung Y, Lei L, Westphal H, Chiang C (1998) Sonic hedgehog is essential to foregut development. Nat Genet 20:58–61

    Article  CAS  Google Scholar 

  • Livitidis A (1973) Esophageal atresia: a method of overbrindging large segment gaps. Z Kinderchir 13:298–306

    Google Scholar 

  • Lopez PJ, Keys C, Pierro A et al (2006) Oesophageal atresia: improved outcome in high-risk groups? J Pediatr Surg 41:331–334

    Article  Google Scholar 

  • Marsh AJ, Wellesley D, Burge D et al (2000) Interstitial deletion of chromosome 17 (del(l7)(q22q23.3)) confirms a link with oesophageal atresia. J Med Genet 37:701–704

    Article  CAS  Google Scholar 

  • Mee RBB, Beasley SW, Auldist AW, Myers NA (1992) Influence of congenital heart disease on management of oesophageal atresia. Pediatr Surg Int 7:90–93

    Article  Google Scholar 

  • Merci J, Hasthorpe S, Farmer P, Hutson JM (1998) relationship between esophageal atresia with tracheoesophageal fistula and vertebral anomalies in mammalian embryos. J Pediatr Surg 33:58–63

    Article  Google Scholar 

  • Nguyen T, Zainabadi K, Bui T et al (2006) Thoracoscopic repair of esophageal atresia and tracheoesophageal fistula: lessons learned. J Laparoendosc Adv Surg Tech A 16:174–178

    Article  Google Scholar 

  • Parker AF, Christie DL, Cahill JL (1979) Incidence and significance of gastroesophageal reflux following repair of esophageal atresia and tracheoesophageal fistula and the need for anti-reflux procedures. J Pediatr Surg 14:5–8

    Article  CAS  Google Scholar 

  • Poenaru D, Laberge JM, Neilson JR, Guttman FM (1993) A new prognostic classification for esophageal atresia. Surgery 113:426–432

    CAS  PubMed  Google Scholar 

  • Puri P, Blake N, O’Donnell B, Guiney EJ (1981) Delayed primary anastomosis following spontaneous growth of esophageal segments in esophageal atresia. J Pediatr Surg 16:180–183

    Article  CAS  Google Scholar 

  • Quan L, Smith DW (1972) The VATER association: vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial dysplasia. Birth Defects 8:75–78

    Google Scholar 

  • Roessler E, Belloni E, Gaudenz K et al (1996) Mutations in the human sonic hedgehog gene cause holoprosencephaly. Nat Genet 14:357–360

    Article  CAS  Google Scholar 

  • Rothenberg SS (2002) Thoracoscopic repair of tracheoesophageal fistula in newborns. J Pediatr Surg 37:869–872

    Article  Google Scholar 

  • Rothenberg SS (2005a) Thoracoscopic repair of esophageal atresia and tracheoesophageal fistula. Semin Pediatr Surg 14:2–7

    Article  Google Scholar 

  • Rothenberg SS (2005b) Esophageal atresia and tracheoesophageal fistula. In: Najmaldin A, Rothenberg S, Crabbe D, Beasley S (eds) Operative endoscopy and endoscopic surgery in infants and children. Hodder Arnold, London, pp 89–97

    Chapter  Google Scholar 

  • Shulman A, Mazkereth R, Zalel Y et al (2002) Prenatal identification of esophageal atresia: the role of ultrasonography for evaluation of functional anatomy. Prenat Diagn 22:669–674

    Article  Google Scholar 

  • Spitz L (1973) Congenital esophageal stenosis distal to associated esophageal atresia. J Pediatr Surg 8:973–974

    Article  CAS  Google Scholar 

  • Spitz L (1996) Esophageal atresia: past, present, and future. J Pediatr Surg 31:19–25

    Article  CAS  Google Scholar 

  • Spitz L, Kiely E, Brereton RJ, Drake D (1993) Management of esophageal atresia. World J Surg 17:296–300

    Article  CAS  Google Scholar 

  • Spitz L, Kiely EM, Morecrofl JA, Drake DP (1994) Oesophageal atresia: at-risk groups for the 1990s. J Pediatr Surg 29:723–725

    Article  CAS  Google Scholar 

  • Spitz L, Kiely E, Pierro A (2004) Gastric transposition in children a 21-year experience. J Pediatr Surg 39:276–281

    Article  Google Scholar 

  • Stringer MD, McKenna KM, Goldstein RB et al (1995) Prenatal diagnosis of esophageal atresia. J Pediatr Surg 30:l258–l1263

    Google Scholar 

  • Yeung CK, Spitz L, Brereton RJ (1992) Congenital esophageal stenosis due to tracheobronchial remnants: a rare but important association with esophageal atresia. J Pediatr Surg 27:852–855

    Article  CAS  Google Scholar 

  • Zhou B, Hutson JM, Farmer PJ et al (1999) Apoptosis in tracheoesophageal embryogenesis in rat embryos with or without adriamycin treatment. J Pediatr Surg 34:872–875

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Pediatric Surgery, Policlinico “Le Scotte”, University of Siena, Siena, Italy

    Mario Messina & Francesco Molinaro

  2. Department of Medical, Surgical and Neurological Sciences, Section of Pediatric Surgery, University of Siena, Siena, Italy

    Mario Messina, Francesco Molinaro & Alfredo Garzi

  3. Università degli Studi di Salerno, Fisciano, Italy

    Alfredo Garzi

  4. Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Pediatric Surgery, University of Siena, Siena, Italy

    Rossella Angotti

Authors
  1. Mario Messina
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  2. Francesco Molinaro
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  3. Alfredo Garzi
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  4. Rossella Angotti
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Corresponding author

Correspondence to Mario Messina .

Editor information

Editors and Affiliations

  1. Department of Pediatrics Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy

    Giuseppe Buonocore

  2. Department of Pediatrics Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy

    Rodolfo Bracci

  3. Liverpool Women’s Hospital Neonatal Unit, Liverpool, UK

    Michael Weindling

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Messina, M., Molinaro, F., Garzi, A., Angotti, R. (2018). Esophageal Atresia of Newborns. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Cham. https://doi.org/10.1007/978-3-319-29489-6_228

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  • DOI: https://doi.org/10.1007/978-3-319-29489-6_228

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-29487-2

  • Online ISBN: 978-3-319-29489-6

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