Definition
Clear cell renal cell carcinoma is a morphologically heterogeneous group of malignant tumors made up of cells with clear or eosinophilic cytoplasm and characteristic vessel formation.
Clinical Features
Seventy percent of cases are found incidentally on imaging. Hematuria and flank pain are the most common signs of the symptomatic cases. Clear cell renal cell carcinoma can be sporadic or occurs in Von HippelāLindau disease. It is a rare, autosomal dominant syndrome consisting of retinal angiomas, hemangioblastomas of the central nervous system, pheochromocytomas, and clear cell renal cell carcinoma.
Incidence
Clear cell renal cell carcinoma is the most common malignancy among renal cell neoplasms, representing roughly 70% of all renal cell tumors.
Age
It occurs in patients around 60ā70 years of age.
Sex
Its male/female ratio is 2:1.
Site
There is no site predilection.
Treatment
Partial or radical...
References
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Sato, Y., Yoshizato, T., Shiraishi, Y., Maekawa, S., Okuno, Y., Kamura, T., Shimamura, T., Sato-Otsubo, A., Nagae, G., Suzuki, H., Nagata, Y., Yoshida, K., Kon, A., Suzuki, Y., Chiba, K., Tanaka, H., Niida, A., Fujimoto, A., Tsunoda, T., Morikawa, T., Maeda, D., Kume, H., Sugano, S., Fukayama, M., Aburatani, H., Sanada, M., Miyano, S., Homma, Y., & Ogawa, S. (2013). Integrated molecular analysis of clear-cell renal cell carcinoma. Nature Genetics, 45(8), 860ā867.
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CaliĆ², A., Segala, D., Martignoni, G. (2019). Clear Cell Renal Cell Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4792-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4792-1
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