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Hemolytic Uremic Syndrome, Genetic

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Glomerulonephritis

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Abstract

The nomenclature of atypical hemolytic uremic syndrome (aHUS) has undergone an evolution as rapid as the scientific understanding of the field during the last decade. Identification of many underlying genetic causes has increased understanding of the major mechanisms of disease. These defects principally, but not exclusively, involve the alternative pathway of complement. Important differences among the specific defects have impact on disease management, and clinical genetics plays a key role in that process. Untreated, aHUS frequently leads to end stage renal disease or death. Fortunately, understanding the major disease mechanisms has allowed development of effective treatment options.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, The Kravis Children’s Hospital at Mount Sinai, The Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Jeffrey M. Saland

  2. Department of Pediatrics, Cohen Children’s Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA

    Laura Castellanos Reyes

Authors
  1. Laura Castellanos Reyes
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  2. Jeffrey M. Saland
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Corresponding author

Correspondence to Jeffrey M. Saland .

Editor information

Editors and Affiliations

  1. Department of Pediatrics, NYU Langone Medical Center, New York, New York, USA

    Howard Trachtman

  2. Hospital of the Univ. of Pennsylvania, Philadelphia, Pennsylvania, USA

    Jonathan J. Hogan

  3. Cleveland Clinic, Cleveland, Ohio, USA

    Leal Herlitz

  4. Nephrology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA

    Edgar V. Lerma

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Reyes, L.C., Saland, J.M. (2018). Hemolytic Uremic Syndrome, Genetic. In: Trachtman, H., Hogan, J., Herlitz, L., Lerma, E. (eds) Glomerulonephritis. Springer, Cham. https://doi.org/10.1007/978-3-319-27334-1_43-1

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  • DOI: https://doi.org/10.1007/978-3-319-27334-1_43-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-27334-1

  • Online ISBN: 978-3-319-27334-1

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