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MALT1 Deficiency

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Encyclopedia of Medical Immunology

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References

  • Bornancin F, Renner F, Touil R, et al. Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation. J Immunol. 2015;194:3723–34.

    Article  CAS  Google Scholar 

  • Brustle A, Brenner D, Knobbe CB, et al. The NF-kappaB regulator MALT1 determines the encephalitogenic potential of Th17 cells. J Clin Invest. 2012;122:4698–709.

    Article  CAS  Google Scholar 

  • Diebold J. Malignant lymphoma of mucosa-associated lymphoid tissue. Ann Pathol. 1988;8:340.

    CAS  PubMed  Google Scholar 

  • Frizinsky S, Rechavi E, Barel O, et al. Novel MALT1 mutation linked to immunodeficiency, immune dysregulation, and an abnormal T cell receptor repertoire. J Clin Immunol. 2019;39:401–13.

    Article  CAS  Google Scholar 

  • Hachmann J, Salvesen GS. The paracaspase MALT1. Biochimie. 2016;122:324–38.

    Article  CAS  Google Scholar 

  • Horsman D, Gascoyne R, Klasa R, Coupland R. t(11;18)(q21;q21.1): a recurring translocation in lymphomas of mucosa-associated lymphoid tissue (MALT)? Genes Chromosomes Cancer. 1992;4:183–7.

    Article  CAS  Google Scholar 

  • Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer. 1983;52:1410–6.

    Article  CAS  Google Scholar 

  • Jabara HH, Ohsumi T, Chou J, et al. A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency. J Allergy Clin Immunol. 2013;132:151–8.

    Article  CAS  Google Scholar 

  • Lin X, Wang D. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin Immunol. 2004;16:429–35.

    Article  CAS  Google Scholar 

  • Mc Guire C, Wieghofer P, Elton L, et al. Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination. J Immunol. 2013;190:2896–903.

    Article  CAS  Google Scholar 

  • McKinnon ML, Rozmus J, Fung SY, Hirschfeld AF, Del Bel KL, Thomas L, et al. Combined immunodeficiency associated with homozygous MALT1 mutations. J Allergy Clin Immunol. 2014;133(5):1458–62.

    Article  CAS  Google Scholar 

  • Oeckinghaus A, Wegener E, Welteke V, et al. Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation. EMBO J. 2007;26:4634–45.

    Article  CAS  Google Scholar 

  • Punwani D, Wang H, Chan AY, Cowan MJ, Mallott J, Sunderam U, et al. Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation. J Clin Immunol. 2015;35(2):135–46.

    Article  CAS  Google Scholar 

  • Quancard J, Klein T, Fung SY, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019;15(3):304–13.

    Article  CAS  Google Scholar 

  • Rosenbaum M, Gewies A, Pechloff K, et al. Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells. Nat Commun. 2019;10:2352.

    Article  Google Scholar 

  • Rozmus J, McDonald R, Fung SY, et al. Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation. Clin Immunol. 2016;168:1–5.

    Article  CAS  Google Scholar 

  • Saba NS, Wong DH, Tanios G, et al. MALT1 inhibition is efficacious in both naive and ibrutinib-resistant chronic lymphocytic leukemia. Cancer Res. 2017;77:7038–48.

    Article  CAS  Google Scholar 

  • Thome M. Multifunctional roles for MALT1 in T-cell activation. Nat Rev Immunol. 2008;8:495–500.

    Article  CAS  Google Scholar 

  • Tusche MW, Ward LA, Vu F, et al. Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets. J Exp Med. 2009;206:2671–83.

    Article  CAS  Google Scholar 

  • Wegener E, Oeckinghaus A, Papadopoulou N, et al. Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. Mol Cell. 2006;23:13–23.

    Article  CAS  Google Scholar 

  • Wiegmann H, Reunert J, Metze D, et al. Refining the dermatological spectrum in primary immunodeficiency: MALT1 deficiency mimicking Netherton- and Omenn syndrome. Br J Dermatol. 2019; https://doi.org/10.1111/bjd.18091.

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Authors and Affiliations

  1. Professor of Medicine and Pediatrics, Indiana University School of Medicine, Immunohematology and Transplantation, Indianapolis, IN, USA

    Robert P. Nelson Jr.

Authors
  1. Robert P. Nelson Jr.
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Correspondence to Robert P. Nelson Jr. .

Editor information

Editors and Affiliations

  1. Molecular Biology, Monash University Dept. Biochemistry &, Clayton, VIC, Australia

    Ian MacKay

  2. Autoimmune Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Noel R. Rose

Section Editor information

  1. University of Washington and Seattle Children's Hospital, Seattle, USA

    M Teresa de la Morena

  2. Professor of Medicine and Pediatrics, Indiana University School of Medicine Immunohematology and Transplantation, Indianapolis, IN, USA

    R. P. Nelson Jr

  3. Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA

    R. P. Nelson Jr

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Nelson, R.P. (2020). MALT1 Deficiency. In: MacKay, I., Rose, N. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9209-2_105-1

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  • DOI: https://doi.org/10.1007/978-1-4614-9209-2_105-1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-9209-2

  • Online ISBN: 978-1-4614-9209-2

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