Reference Work Entry

Encyclopedia of Systems Biology

pp 773-777

Functional/Signature Network Module for Target Pathway/Gene Discovery

  • Shipra AgrawalAffiliated withBioCOS Life Sciences Pvt. Limited, Institute of Bioinformatics and Applied Biotechnology
  • , M. R. Satyanarayana RaoAffiliated withChromatin Biology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Research Email author 

Synonyms

Co-expression network; Expression signature; Functional GO and pathway-based network; Genomics network

Definition

High-throughput molecular biology data is often analyzed and represented today through molecular networks. The network of interacting proteins/genes is an undirected network, where proteins/genes are represented by nodes and the interaction between them are represented by edges. The multiple nodes and corresponding edges in a network together form modules/subnetworks that manifest high internal similarity/correlation (i.e., modular networks). These modules form an independent connected component with each other, while they are sparsely connected with the rest of the network (Erten et al. 2009). The network modules carrying biologically meaningful information are termed as functional modules. A general concept on identifying signature and functional module is described below.

Characteristics

Identification of Signature and Functional Network Modules

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