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Diseases of the Placenta

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Abstract

The placenta is crucial for fetal growth and survival, performing the most important functions of many somatic organs before birth. Thus, pathologic processes interfering with placental function may result in abnormalities of fetal growth or development, malformation, or stillbirth, and there is increasing recognition that some long-term (especially neurologic) disabilities can be traced to injury occurring before birth. The purpose of this chapter is to describe clinically important placental lesions and to emphasize the context in which these lesions are directly or indirectly important to the fetus, the mother, or both.

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References

  1. Abramowsky C, Beyer-Patterson P et al (1991) Nonsyphilitic spirochetosis in second-trimester fetuses. Pediatr Pathol 11:827–838

    Article  PubMed  CAS  Google Scholar 

  2. Adams-Chapman I, Vaucher YE et al (2002) Maternal floor infarction of the placenta: association with central nervous system injury and adverse neurodevelopmental outcome. J Perinatol 22:236–241

    Article  PubMed  Google Scholar 

  3. Al-Adnani M, Kiho L et al (2008) Recurrent massive perivillous fibrin deposition associated with polymyositis: a case report and review of the literature. Pediatr Dev Pathol 11:226–229

    Article  PubMed  Google Scholar 

  4. Altshuler G (1984) Chorangiosis. An important placental sign of neonatal morbidity and mortality. Arch Pathol Lab Med 108:71–74

    PubMed  CAS  Google Scholar 

  5. Altshuler G, Hyde S (1989) Meconium-induced vasocontraction: a potential cause of cerebral and other fetal hypoperfusion and of poor pregnancy outcome. J Child Neurol 4:137–142

    Article  PubMed  CAS  Google Scholar 

  6. Ananth CV, Oyelese Y et al (2005) Placental abruption in the United States, 1979 through 2001: temporal trends and potential determinants. Am J Obstet Gynecol 192:191–198

    Article  PubMed  Google Scholar 

  7. Ananth CV, Vintzileos AM et al (1998) Standards of birth weight in twin gestations stratified by placental chorionicity. Obstet Gynecol 91:917–924

    Article  PubMed  CAS  Google Scholar 

  8. Arias F, Rodriguez L et al (1993) Maternal placental vasculopathy and infection: two distinct subgroups among patients with preterm labor and preterm ruptured membranes. Am J Obstet Gynecol 168:585–591

    PubMed  CAS  Google Scholar 

  9. Arias F, Romero R et al (1998) Thrombophilia: A mechanism of disease in women with adverse pregnancy outcome and thrombotic lesions in the placenta. J Matern Fetal Med 7:277–286

    Article  PubMed  CAS  Google Scholar 

  10. Ariel IB, Anteby E et al (2004) Placental pathology in fetal thrombophilia. Hum Pathol 35:729–733

    Article  PubMed  Google Scholar 

  11. Badawi N, Felix JF et al (2005) Cerebral palsy following term newborn encephalopathy. Devel Med Child Neurol 47:293–298

    Article  Google Scholar 

  12. Baergen RN (2007) Cord abnormalities, structural lesions, and cord accidents. Semin Diag Pathol 24:23–32

    Article  Google Scholar 

  13. Baergen RN, Malicki D et al (2001) Morbidity. mortality, and placental pathology in excessively long umbilical cords; retrospective study. Pediatr Devel Pathol 4:144–153

    Article  CAS  Google Scholar 

  14. Baldwin VJ (1994) Pathology of multiple pregnancy. Springer, New York

    Book  Google Scholar 

  15. Barth WH Jr, Genest DR et al (1996) Uterine arcuate artery Doppler and decidual microvascular pathology in pregnancies complicated by type I diabetes mellitus. Ultrasound Obstet Gynecol 8:98–103

    Article  PubMed  Google Scholar 

  16. Baschat AA, Gungor S et al (2007) Nucleated red blood cell counts in the first week of life: a critical appraisal of relationships with perinatal outcome in preterm growth restricted neonates. Am J Obstet Gynecol 197(3):286.e1–286.e8

    Article  Google Scholar 

  17. Benirschke K, Kaufmann P et al (2006) Pathology of the human placenta, 5th edn. Springer, New York

    Google Scholar 

  18. Benirschke K, Masliah E (2001) The placenta in multiple pregnancy: outstanding issues. Reprod Fertil Dev 13(7–8):615–622

    Article  PubMed  CAS  Google Scholar 

  19. Berg TG, Rayburn WF (1995) Umbilical cord length and acid-base balance at delivery. J Reprod Med 40:1–12

    Google Scholar 

  20. Bieber FR, Nance WE et al (1981) Genetic studies of an acardiac monster: evidence of polar body twinning in man. Science 213:775–777

    Article  PubMed  CAS  Google Scholar 

  21. Blanc WA (1959) Amnionic infection syndrome. Pathogenesis, morphology, and significance in circumnatal mortality. Clin Obstet Gynaecol 2:705–734

    CAS  Google Scholar 

  22. Bloomfield RD, Suarez JR et al (1978) The placenta: a diagnostic tool in sickle cell disorders. J Natl Med Assoc 70:87–88

    PubMed  CAS  Google Scholar 

  23. Boyd JD, Hamilton WJ (1970) The human placenta. Heffer, Cambridge

    Google Scholar 

  24. Bruner JP, Anderson TL et al (1998) Placental pathophysiology of the twin: oligohydramnios-polyhydramnios sequence and the twin-twin transfusion syndrome. Placenta 19:81–86

    Article  PubMed  CAS  Google Scholar 

  25. Burke CJ, Tannenberg AE (1995) Prenatal brain damage and placental infarction-An autopsy study. Devel Med Child Neurol 37:555–562

    Article  CAS  Google Scholar 

  26. Chan OT, Mannino FL et al (2007) A retrospective analysis of placentas from twin pregnancies derived from assisted reproductive technology. Twin Res Hum Genet 10(2):385–393

    Article  PubMed  Google Scholar 

  27. Cleary GM, Wiswell TE (1998) Meconium-stained amnionic fluid and the meconium aspiration syndrome. An update. Pediatr Clin North Amer 45:511–529

    Article  CAS  Google Scholar 

  28. Cooperstock MS, Tummara R et al (2000) Twin birth weight discordance and risk of preterm birth. Am J Obstet Gynecol 183:63–67

    PubMed  CAS  Google Scholar 

  29. Curtin WM, Shehata BM et al (2002) The feasibility of using histologic placental sections to predict newborn nucleated red blood cell counts. Obstet Gynecol 110:305–310

    Article  Google Scholar 

  30. Dahms B, Boyd T et al (2002) Severe perinatal liver disease associated with fetal thrombotic vasculopathy in the placenta. Pediatr Devel Pathol 5:80–85

    Article  Google Scholar 

  31. Davis BH, Olsen S et al (1998) Detection of fetal red cells in fetomaternal hemorrhage using a fetal hemoglobin monoclonal antibody by flow cytometry. Transfusion 38:749–756

    Article  PubMed  CAS  Google Scholar 

  32. De Laat MWM, van Alderen ED et al (2007) The umbilical coiling index in complicated pregnancy. Eur J Obstet Gynecol Reprod Biol 130:66–72

    Article  PubMed  Google Scholar 

  33. Deans A, Jauniaux E (1998) Prenatal diagnosis and outcome of subamniotic hematomas. Ultrasound Obstet Gynecol 11:319–323

    Article  PubMed  CAS  Google Scholar 

  34. Decastel M, Leborgne-Samuel Y (1999) Morphological features of the human umbilical vein in normal, sickle cell trait, and sickle cell disease pregnancies. Hum Pathol 30(1):13–20

    Article  PubMed  CAS  Google Scholar 

  35. DeSa DJ (1973) Intimal cushions of foetal placental veins. J Pathol 110:347–352

    Article  Google Scholar 

  36. Di Naro E, Ghezzi F et al (2001) Umbilical vein blood flow in fetuses with normal and lean umbilical cord. Ultrasound Obstet Gynecol 17:224–228

    Article  PubMed  Google Scholar 

  37. Dizon-Townson DS, Meline L et al (1997) Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction. Am J Obstet Gynecol 177:402–405

    Article  PubMed  CAS  Google Scholar 

  38. Doss BJ, Jacques SM et al (1998) Maternal scleroderma: placenta findings and perinatal outcome. Hum Pathol 28:1524–1530

    Article  Google Scholar 

  39. Dr G, Singer DB (1992) Estimating the time of death in stillborn fetuses: III. External fetal examination; a study of 86 stillborns. Obstet Gynecol 80:593–600

    Google Scholar 

  40. Esplin MS (2006) Preterm birth: a review of genetic factors and future directions for genetic study. Obstet Gynecol Survey 61:800–806

    Article  Google Scholar 

  41. Fernandes BJ, von Dadelszen P et al (2007) Flow cytometric assessment of feto-maternal hemorrhage; a comparison with Bettke-Kleihauer. Prenat Diagn 27:641–643

    Article  PubMed  Google Scholar 

  42. Fok RY, Pavlova Z et al (1990) The correlation of arterial lesions with umbilical artery Doppler velocimetry in the placentas of small-for-dates pregnancies. Obstet Gynecol 75:578–583

    PubMed  CAS  Google Scholar 

  43. Fox H (1966) Thrombosis of the foetal stem arteries in the human placenta. J Obstet Gynaecol Br Commonwealth 73:961–965

    Article  CAS  Google Scholar 

  44. Fox H (1997) Pathology of the placenta, 2nd edn. Saunders, Philadelphia

    Google Scholar 

  45. Fox H, Sebire NJ (2007) Pathology of the placenta, 3rd edn. Saunders, Philadelphia

    Google Scholar 

  46. Frank HG, Malekzadeh F et al (1994) Immunohistochemistry of two different types of placental fibrinoid. Acta Anat 150:55–68

    Article  PubMed  CAS  Google Scholar 

  47. Fraser RB, Wright JR (2002) Eosinophilic/T-cell chorionic vasculitis. Pedatri Dev Pathol 5:350–355

    Article  Google Scholar 

  48. Gardella C, Riley DE et al (2004) Identification and sequencing of bacterial rDNAs in culture-negative amniotic fluid from women in premature labor. Am J Perinatol 21:319–323

    Article  PubMed  Google Scholar 

  49. Gardiner JP (1922) The umbilical cord: normal length; length in cord complications; etiology and frequency of coiling. Surg Gynecol Obstet 34:252–256

    Google Scholar 

  50. Genest DR (1992) Estimating the time of death in stillborn fetuses: II. Histologic evaluation of the placenta; a study of 71 stillborns. Obstet Gynecol 80:585–592

    PubMed  CAS  Google Scholar 

  51. Genest DR, Williams MA et al (1992) Estimating the time of death in stillborn fetuses: I. Histologic evaluation of fetal organs; an autopsy study of 150 stillborns. Obstet Gynecol 80:575–584

    PubMed  CAS  Google Scholar 

  52. Ghidini A, Spong CY (2001) Severe meconium aspiration syndrome is not caused by aspiration of meconium. Am J Obstet Gynecol 185:931–938

    Article  PubMed  CAS  Google Scholar 

  53. Giles WB, Trudinger BJ et al (1985) Fetal umbilical artery flow velocity waveforms and placental resistance: pathological correlation. Brit J Obstet Gynaecol 92:31–38

    Article  CAS  Google Scholar 

  54. Gomez R, Romero R et al (1998) The fetal inflammatory response syndrome. Am J Obstet Gynecol 179:194–202

    Article  PubMed  CAS  Google Scholar 

  55. Greer IA (1999) Thrombosis in pregnancy: maternal and fetal issues. Lancet 353:1258–1265

    Article  PubMed  CAS  Google Scholar 

  56. Gupta N, Sebire NJ et al (2004) Massive perivillous fibrin deposition associated with discordant fetal growth in a dichorionic twin pregnancy. J Obstet Gynaecol 24:579–580

    Article  PubMed  CAS  Google Scholar 

  57. Han YW, Redline RW et al (2004) Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth. Infect Immun 72:2272–2279

    Article  PubMed  CAS  Google Scholar 

  58. Hansen AR, Collins MH et al (2000) Very low birthweight infant's placenta and its relation to pregnancy and fetal characteristics. Pediatr Devel Pathol 3:419–430

    Article  CAS  Google Scholar 

  59. Hansen AR, Collins MH et al (2000) Very low birthweight placenta; clustering of morphologic characteristics. Pediatr Devel Pathol 3:431–438

    Article  CAS  Google Scholar 

  60. Hashimoto K, Clapp JF (2003) The effect of nuchal cord on amniotic fluid and cord blood erythropoetin at delivery. J Soc Gynecol Investig 10:406–411

    Article  PubMed  CAS  Google Scholar 

  61. Hecht JL, Allred EN et al (2008) Histologic characteristics of singleton placentas delivered before the 28th week of gestation. Pathology 40:372–376

    Article  PubMed  Google Scholar 

  62. Heller DS, Rush D et al (2003) Subchorionic hematoma associated with thrombophilia: report of three cases. Pediatr Dev Pathol 6:261–264

    PubMed  Google Scholar 

  63. Hermansen MC (2001) Nucleated red blood cells in the fetus and newborn. Arch Dis Child Fetal Neonatal Ed 84:F211–F215

    Article  PubMed  CAS  Google Scholar 

  64. Hershkovitz R, Silberstein T et al (2001) Risk factors associated with true knots of the umbilical cord. Eur J Obstet Gyneco Biol 93:36–39

    Article  Google Scholar 

  65. Hill GB (1998) Preterm birth: associations with genital and possibly oral microflora. Ann Periodontal 3:222–232

    Article  CAS  Google Scholar 

  66. Hung NA, Jackson C et al (2005) Pregnancy-related polymyositis and massive perivillous fibrin deposition in the placenta: are they pathogenetically related? Arthr Rhematism 55:154–156

    Article  Google Scholar 

  67. Huppertz B, Kadyrov M et al (2006) Apoptosis and its role in the trophoblast. Am J Obstet Gynecol 195:29–39

    Article  PubMed  Google Scholar 

  68. Ibdah JA, Bennett MJ et al (1999) A fetal fatty acid oxidation disorder as a cause of liver disease in pregnant women. N Engl J Med 340:1723–1731

    Article  PubMed  CAS  Google Scholar 

  69. Jacques SM, Qureshi F (1998) Chronic chorioamnionitis: a clinicopathologic and immunohistochemical study. Hum Pathol 29:1457–1461

    Article  PubMed  CAS  Google Scholar 

  70. Jamshed S, Kouides P et al (2007) Pathology of thrombotic thrombocytopenic purpura in the placenta, with emphasis on the “snowman sign.”. Pediatr Dev Pathol 10:455–462

    Article  PubMed  Google Scholar 

  71. Jauniaux E, Nicolaides KH et al (1997) Perinatal features associated with placental mesenchymal dysplasia. Placenta 18:701–706

    Article  PubMed  CAS  Google Scholar 

  72. Kalousek DK, Bamforth S (1988) Amnion rupture sequence in previable fetuses. Am J Med Genet 31:63–73

    Article  PubMed  CAS  Google Scholar 

  73. Kalousek DK, Barrett I (1994) Confined placental mosaicism and stillbirth. Pediatr Pathol 14:151–159

    Article  PubMed  CAS  Google Scholar 

  74. Kalousek DK, Fitch N et al (1990) Pathology of the human embryo and previable fetus. An atlas. Springer, New York

    Book  Google Scholar 

  75. Kaplan C, Blanc WA et al (1982) Identification of erythrocytes in intervillous thrombi. A study using immunoperoxidase identification of hemoglobins. Hum Pathol 13:554–557

    Article  PubMed  CAS  Google Scholar 

  76. Katz VL, DiTomasso J et al (2002) Activated protein C resistance associated with maternal floor infarction treated with low-molecular-weight heparin. Am J Perinatol 19:273–277

    Article  PubMed  Google Scholar 

  77. Katzman PJ, Genest DR (2002) Maternal floor infarction and massive perivillous fibrin deposition: histological definitions, association with intrauterine fetal growth restriction, and risk of recurrence. Pediatr Devel Pathol 5:159–164

    Article  Google Scholar 

  78. Keenan WJ, Steichen JJ et al (1977) Placental pathology compared with clinical outcome. Am J Dis Child 131:1224–1227

    PubMed  CAS  Google Scholar 

  79. Keogh JM, Badawi N (2006) The origins of cerebral palsy. Curr Opin Neurol 19:129–134

    Article  PubMed  Google Scholar 

  80. Khong TY (1999) The placenta in maternal hyperhomocysteinaemia. Br J Obstet Gynaecol 106:2733–2738

    Google Scholar 

  81. Kim CJ, Yoon BH et al (2001) Umbilical arteritis and phlebitis mark different stages of the fetal inflammatory response. Am J Obstet Gynecol 185(2):496–500

    Article  PubMed  CAS  Google Scholar 

  82. King EL, Redline RW et al (2004) Myocytes of chorionic vessels from placentas with meconium-associated vascular necrosis exhibit apoptotic markers. Hum Pathol 35(4):412–417

    Article  PubMed  CAS  Google Scholar 

  83. Kraus FT, Acheen VI (1999) Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy. Hum Pathol 30:759–769

    Article  PubMed  CAS  Google Scholar 

  84. Kraus FT, Redline RW et al (2004) Placental pathology. ARP/AFIP, Washington DC

    Google Scholar 

  85. Kumar D, Fung W et al (2006) Proinflammatory cytokines found in amniotic fluid induce collagen remodeling, apoptosis, and biophysical weakening of cultured human fetal membranes. Biol Report 74(1):29–34

    Article  CAS  Google Scholar 

  86. Lash GB, Quenby S et al (2008) Gestational diseases – a workshop report. Placenta 22:S92–S94

    Article  Google Scholar 

  87. Leistra-Leistra MJ, Timmer A et al (2004) Fetal thrombotic vasculopathy in the placenta: a thrombophilic connection between pregnancy complications and neonatal thrombosis? Placenta 25(Suppl A):S102–S105

    Article  PubMed  CAS  Google Scholar 

  88. Leviton A, Paneth N et al (1999) Maternal infection, fetal inflammatory response, and brain damage in very low birth weight infants. Developmental Epidemiology Network Investigators. Pediatr Res 46(5):566–575

    Article  PubMed  CAS  Google Scholar 

  89. Lim FT, Scherjon SA et al (2000) Association of stress during delivery with increased numbers of nucleated cells and hematologic progenitor cells in umbilical cord blood. Am J Obstet Gynecol 183:1144–1151

    Article  PubMed  CAS  Google Scholar 

  90. Lim LK, Zhou Y et al (1997) Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia. Am J Pathol 151:1809–1818

    PubMed  CAS  Google Scholar 

  91. Lin MG (2006) Umbilical cord prolapse. Obstet Gynecol Surv 61(4):269–277

    Article  PubMed  Google Scholar 

  92. Machin GA, Ackerman J et al (2000) Abnormal umbilical cord coiling is associated with adverse perinatal outcomes. Pediatr Devel Pathol 3:462–471

    Article  CAS  Google Scholar 

  93. Magid MS, Kaplan C et al (1998) Placental pathology in systemic lupus erythematosus: a prospective study. Am J Obstet Gynecol 179:226–236

    Article  PubMed  CAS  Google Scholar 

  94. Many A, Elad R et al (2002) Third trimester unexplained intrauterine fetal death is associated with inherited thrombophilia. Obstet Gynecol 99:684–687

    Article  PubMed  Google Scholar 

  95. Many A, Schreiber L et al (2001) Pathologic features of the placenta in women with severe pregnancy complications and thrombophilia. Obstet Gynecol 98:1041–1044

    Article  PubMed  CAS  Google Scholar 

  96. Matern D, Shehata BM et al (2001) Placental floor infarction complicating the pregnancy of a fetus with long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency. Mol Genet Metab 72:265–268

    Article  PubMed  CAS  Google Scholar 

  97. McDonald DG, Kelehan P et al (2004) Placental fetal thrombotic vasculopathy is associated with neonatal encephalopathy. Hum Pathol 35:875–880

    Article  PubMed  Google Scholar 

  98. Menezo YJ, Sakkas D (2002) Monozygotic twining: is it related to apoptosis in the embryo? Hum Reprod 17:247–248

    Article  PubMed  Google Scholar 

  99. Miller PW, Coen RW et al (1985) Dating the time interval from meconium passage to birth. Obstet Gynecol 66:459–462

    PubMed  CAS  Google Scholar 

  100. Mitra SC, Seshan SV et al (2000) Placental vessel morphometry in growth retardation and increased resistance of the umbilical artery Doppler flow. J Matern Fetal Med 9:282–286

    Article  PubMed  CAS  Google Scholar 

  101. Moscoso G, Jauniaux E et al (1991) Placental vascular anomaly with diffuse mesenchymal stem villous hyperplasia. A new clinico-pathological entity? Path Res Pract 187:324–328

    Article  PubMed  CAS  Google Scholar 

  102. Mutter WP, Karumanchi SA (2008) Molecular mechanisms of preeclampsia. Microvasc Res 75:1–8

    Article  PubMed  CAS  Google Scholar 

  103. Myerson D, Parkin RK (2006) The pathogenesis of villitis of unknown etiology: analysis with a new conjoint immunohistochemistry-in situ hybridization procedure to identify specific maternal and fetal cells. Pediatr Dev Pathol 9(4):257–265

    Article  PubMed  Google Scholar 

  104. Naeye RL (1985) Umbilical cord length: clinical significance. J Pediatr 107:278–281

    Article  PubMed  CAS  Google Scholar 

  105. Naeye RL, Maisels J et al (1983) The clinical significance of placental villous edema. Pediatrics 71:588–594

    PubMed  CAS  Google Scholar 

  106. Naeye RL, Shaffer ML (2005) Postnatal laboratory timers of antenatal hypoxic-ischemic brain damage. J Perinatol 25:664–668

    Article  PubMed  Google Scholar 

  107. Nelson KB, Dambrosia JM et al (1998) Neonatal cytokines and coagulation factors in children with cerebral palsy. Ann Neurol 44:665–675

    Article  PubMed  CAS  Google Scholar 

  108. Nelson KB, Dambrosia JM et al (2005) Genetic polymorphisms and cerebral palsy in very preterm infants. Pediatr Res 57:494–499

    Article  PubMed  CAS  Google Scholar 

  109. Nelson KB, Grether KJ (1998) Potentially asphyxiating conditions and spastic cerebral palsy in infants of normal birth weight. Am J Obstet Gynecol 179:507–513

    Article  PubMed  CAS  Google Scholar 

  110. Ogino S, Redline RW (2000) Villous capillary lesions of the placenta: Distinctions between chorangioma, chorangiomatosis, and chorangiosis. Hum Pathol 31:945–954

    Article  PubMed  CAS  Google Scholar 

  111. Ohyama M, Itani Y et al (2002) Re-evaluation of chorioamnionitis and funisitis with a special reference to subacute chorioamnionitis. Hum Pathol 33:183–190

    Article  PubMed  Google Scholar 

  112. Ordi J, Ismail MR et al (1998) Massive chronic intervillositis of the placenta associated with malaria infection. Am J Surg Pathol 22:1006–1011

    Article  PubMed  CAS  Google Scholar 

  113. Parast MM, Crum CP et al (2008) Placental histological criteria for umbilical flow restriction in unexplained stillbirth. Hum Pathol 39:948–953

    Article  PubMed  Google Scholar 

  114. Patel D, Dawson M et al (1989) Umbilical cord circumference at birth. Am J Dis Child 143:638–639

    PubMed  CAS  Google Scholar 

  115. Peng HW, Levitin-Smith M et al (2006) Umbilical cord stricture and overcoiling are common causes of fetal demise. Pediatr Dev Pathol 9:14–19

    Article  PubMed  Google Scholar 

  116. Pham T, Steele J et al (2006) Placental mesenchymal dysplasia is associated with high rates of intrauterine growth restriction and fetal demise. A report of 11 new cases and review of the literature. AOLP 126:67–78

    Google Scholar 

  117. Pharaoh P, Adi Y (2000) Consequences of in-utero death in twin pregnancy. Lancet 355:1597–1602

    Article  Google Scholar 

  118. Phelan JP, Korst LM et al (1998) Neonatal nucleated red blood cell and lymphocyte counts in fetal brain injury. Obstet Gynecol 91:485–489

    Article  PubMed  CAS  Google Scholar 

  119. Qureshi F, Jacques SM (1994) Marked segmental thinning of the umbilical cord vessels. Arch Pathol Lab Med 118:826–830

    PubMed  CAS  Google Scholar 

  120. Raio L, Ghezzi F (1998) The clinical significance of antenatal detection of discordant umbilical arteries. Obstet Gynecol 91:86–91

    Article  PubMed  CAS  Google Scholar 

  121. Raio L, Ghezzi F et al (1999) Prenatal diagnosis of a lean umbilical cord: A simple marker for the fetus at risk of being small for gestational age at birth. Ultrasound Obstet Gynecol 13:176–180

    Article  PubMed  CAS  Google Scholar 

  122. Rakheja D, Bennett MJ et al (2002) Long-chain L-3-hydroxyacyl-coenzyme A dehydrogenase deficiency: a molecular and biochemical review. Lab Invest 82:815–824

    PubMed  CAS  Google Scholar 

  123. Rand JH (2000) Antiphospholipid antibody-mediated disruption of the annexin-V antithrombotic shield: a thrombogenic mechanism for the antiphospholipid syndrome. J Autoimmun 15:107–111

    Article  PubMed  CAS  Google Scholar 

  124. Rayne SC, Kraus FT (1993) Placental thrombi and other vascular lesions. Classification, morphology, and clinical correlations. Pathol Res Pract 189:2–17

    Article  PubMed  CAS  Google Scholar 

  125. Redline RW (1988) Role of local immunosuppression in murine fetoplacental listeriosis. J Clin Invest 79:1234–1241

    Article  Google Scholar 

  126. Redline RW (1988) Specific defects in the anti-listerial immune response in discrete regions of the murine uterus and placenta account for susceptibility to infection. J Immunol 140:3947–3955

    PubMed  CAS  Google Scholar 

  127. Redline RW (2002) Clinically and biologically relevant patterns of placental inflammation. Pediatr Dev Pathol 5:326–328

    Article  PubMed  Google Scholar 

  128. Redline RW (2004) Clinical and pathological umbilical cord abnormalities in fetal thrombotic vasculopathy. Hum Pathol 35:1494–1498

    Article  PubMed  CAS  Google Scholar 

  129. Redline RW (2004) Placental inflammation. Seminars Neonat 9:265–274

    Article  Google Scholar 

  130. Redline RW (2005) Severe fetal placental vascular lesions in term infants with neurologic impairment. Am J Obstet Gynecol 192:452–457

    Article  PubMed  Google Scholar 

  131. Redline RW (2006) Inflammatory responses in the placenta and umbilical cord. Sem Fetal and Neonat Med 11:296–301

    Article  Google Scholar 

  132. Redline RW (2006) Thrombophilia and placental pathology. Clin Obstet and Gynecol 49(4):885–894

    Article  Google Scholar 

  133. Redline RW (2006) Placental pathology and cerebral palsy. Clin Perinat 33:503–516

    Article  Google Scholar 

  134. Redline RW (2007) Infections and other inflammatory conditions. Sem Diag Pathol 24:5–13

    Article  Google Scholar 

  135. Redline RW (2007) Villitis of unknown etiology: noninfectious chronic villitis in the placenta. Hum Pathol 38(10):1439–1446

    Article  PubMed  Google Scholar 

  136. Redline RW (2008) Placental pathology: a systematic approach with clinical correlations. Placenta 29:S86–S89

    Article  PubMed  Google Scholar 

  137. Redline RW (2008) Elevated circulating fetal nucleated red blood cells and placental pathology in term infants who develop cerebral palsy. Hum Pathol 39:1378–1384

    Article  PubMed  Google Scholar 

  138. Redline RW, Ariel IB et al (2004) Fetal vascular obstructive lesions: Nosology and reproducibility of placental reaction patterns. Pediatr Devel Pathol 7:443–452

    Article  Google Scholar 

  139. Redline RW, Boyd T et al (2004) Maternal vascular underperfusion: nosology and reproducibility of placental reaction patterns. Pediatr Devel Pathol 7:237–249

    Google Scholar 

  140. Redline RW, Dinesh S et al (2001) Placental lesions associated with abnormal growth in twins. Pediatr Dev Pathol 4:473–481

    Article  PubMed  CAS  Google Scholar 

  141. Redline RW, Faye-Petersen O et al (2003) Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol 6:435–448

    Article  PubMed  Google Scholar 

  142. Redline RW, Hassold T et al (1998) Determinants of villous trophoblastic hyperplasia in spontaneous abortions. Mod Pathol 11(8):762–768

    PubMed  CAS  Google Scholar 

  143. Redline RW, Jiang JG et al (2003) Discordancy for maternal floor infarction in dizygotic twin placentas. Hum Pathol 34:822–824

    Article  PubMed  Google Scholar 

  144. Redline RW, Minich N et al (2007) Placental lesions as predictors of cerebral palsy and abnormal neurocognitive function in extremely low birth weight infants (<1kg). Pediatr Dev Pathol 10:282–292

    Article  PubMed  Google Scholar 

  145. Redline RW, O' Riordan MA (2000) Placental lesions associated with cerebral palsy and neurologic impairment following term birth. Arch Pathol Lab Med 124:1785–1791

    PubMed  CAS  Google Scholar 

  146. Redline RW, Pappin A (1995) Fetal thrombotic vasculopathy: the clinical significance of extensive avascular villi. Hum Pathol 26:80–85

    Article  PubMed  CAS  Google Scholar 

  147. Redline R, Patterson R (1993) Villitis of unknown etiology is associated with major infiltration of fetal tissues by maternal cells. Am J Pathol 143:332–336

    Google Scholar 

  148. Redline RW, Patterson P (1994) Patterns of placental injury: correlation with gestational age, placental weight, and clinical diagnosis. Arch Pathol Lab Med 118:698–701

    PubMed  CAS  Google Scholar 

  149. Redline RW, Patterson P (1995) Preeclampsia is associated with an excess of proliferative immature intermediate trophoblast. Hum Pathol 26:594–600

    Article  PubMed  CAS  Google Scholar 

  150. Redline RW, Wilson-Costello D et al (1998) Placental lesions associated with neurologic impairment and cerebral palsy in very low birth weight infants. Arch Pathol Lab Med 122:1091–1098

    PubMed  CAS  Google Scholar 

  151. Redline RW, Wilson-Costello D et al (1999) Chronic peripheral separation of placenta. The significance of diffuse chorioamniotic hemosiderosis. Am J Clin Pathol 111:804–810

    PubMed  CAS  Google Scholar 

  152. Resnik R (2002) Intrauterine growth restriction. Obstet Gynecol 99:490–496

    Article  PubMed  Google Scholar 

  153. Reynolds MA, Schieve LA et al (2003) Trends in multiple births conceived using assisted reproductive technology, United States, 1997–2000. Pediatrics 111:1159–1162

    PubMed  Google Scholar 

  154. Rigano S, Bozzo M et al (2001) Early and persistent reduction in umbilical vein flow in the growth restricted fetus: A longitudinal study. Am J Obstet Gynecol 185:834–838

    Article  PubMed  CAS  Google Scholar 

  155. Rodger MA, Paidas M et al (2008) Inherited thrombophilia and pregnancy complications revisited. Obstet Gynecol 112:320–324

    Article  PubMed  Google Scholar 

  156. Rodriguez MM, Chaves F et al (2002) Value of autopsy in nonimmune hydrops fetalis: Series of 51 stillborn fetuses. Pediatr Devel Pathol 5:365–374

    Article  Google Scholar 

  157. Rogers BB, Alexander JM et al (2002) Umbilical vein interleukin-6 levels correlate with the severity of placental inflammation and gestational age. Hum Pathol 33:335–340

    Article  PubMed  CAS  Google Scholar 

  158. Salafia CM (1997) Placental pathology of fetal growth restriction. Clin Obstet Gynaecol 40:740–749

    Article  CAS  Google Scholar 

  159. Salafia CM, Cowchock FS (1997) Placental pathology and antiphospholipid antibodies: a descriptive study. Am J Perinatol 14(8):435–441

    Article  PubMed  CAS  Google Scholar 

  160. Salafia CM, Pezzullo JC et al (1997) Placental pathology of absent and reversed end-diastolic flow in growth-restricted fetuses. Obstet Gynecol 90:830–836

    Article  PubMed  CAS  Google Scholar 

  161. Sander CH (1980) Hemorrhagic endovasculitis and hemorrhagic villitis of the placenta. Arch Pathol Lab Med 104:371–373

    PubMed  CAS  Google Scholar 

  162. Sander CM, Gilliland D et al (2002) Livebirths with placental hemorrhagic vasculitis. Interlesional relationships and perinatal outcomes. Arch Pathol Lab Med 126:157–164

    PubMed  Google Scholar 

  163. Sato Y, Benirschke K (2006) Increased prevalence of fetal thrombi in monochorionic-twin placentas. Pediatrics 117(1):e113–e117

    Article  PubMed  Google Scholar 

  164. Sato Y, Benirschke K (2006) Umbilical arterial thrombosis with vascular wall necrosis: clinicopathologic findings of 11 cases. Placenta 27:715–718

    Article  PubMed  CAS  Google Scholar 

  165. Scott JM (1983) Fibrinous vasculosis in the human placenta. Placenta 4:87–100

    Article  PubMed  CAS  Google Scholar 

  166. Sebire NJ, Backos M et al (2002) Placental massive perivillous fibrin deposition associated with antiphospholipid antibody syndrome. Br J Obstet Gynaecol 109:570–573

    Article  CAS  Google Scholar 

  167. Sebire NJ, Sepulveda W (2008) Correlating placental pathology with ultrasound findings. J Clin Pathol 61:1276–1284

    Google Scholar 

  168. Sepulveda W, Corral E et al (2003) Umbilical artery aneurysm: prenatal identification in three fetuses with trisomy 18. Ultra Obstet Gynecol 21:292–296

    Article  CAS  Google Scholar 

  169. Shamonki JM, Salmon JE et al (2007) Excessive complement is associated with placental injury in patients with antiphospholipid antibodies. Am J Obstet Gynecol 196(2):167.e1–167.e5

    Article  CAS  Google Scholar 

  170. Shanklin DR, Scott JS (1975) Massive subchorial thrombohaematoma. (Breus’ mole). Br J Obstet Gynaecol 82:476–487

    Article  PubMed  CAS  Google Scholar 

  171. Shekhawat P, Matern D et al (2005) Fetal fatty acid oxidation disorders, their effect on maternal health and neonatal outcome: Impact of expanded newborn screening on their diagnosis and management. Pediatr Res 57:78R–86R

    Article  PubMed  Google Scholar 

  172. Shih I-M, Seidman JD et al (1999) Placental site nodule and characterization of distinctive types of intermediate trophoblast. Hum Pathol 30:687–694

    Article  PubMed  CAS  Google Scholar 

  173. Sienko A, Altshuler G (1999) Meconium-induced umbilical vascular necrosis in abortuses and fetuses: a histopathologic study for cytokines. Obstet Gynecol 94:415–420

    Article  PubMed  CAS  Google Scholar 

  174. Silver RK, Dooley SL et al (1987) Umbilical cord size and amniotic fluid volume in prolonged pregnancy. Am J Obstet Gynecol 157:716–720

    PubMed  CAS  Google Scholar 

  175. Soernes T (1995) Umbilical cord encirclements and fetal growth restriction. Obstet Gynecol 86:725–728

    Article  Google Scholar 

  176. Sohan K, Carroll SG et al (2001) Analysis of outcome in hydrops fetalis in relation to gestational age at diagnosis, cause and treatment. Acta Obstet Gynecol Scand 80:726–730

    Article  PubMed  CAS  Google Scholar 

  177. Soma H, Watanabe Y et al (1996) Chorangiosis and chorangioma in three cohorts of placentas from Nepal, Tibet, and Japan. Reprod Fertil Devel 7:1533–1538

    Article  Google Scholar 

  178. Souter VL, Kapur RP et al (2003) A report of dizygous monochorionic twins. NEJM 349:154–158

    Article  PubMed  Google Scholar 

  179. Steffensen T, Gilbert-Barness E et al (2008) Placental pathology in TRAP sequence: clinical and pathogenetic implication. Fetal Pediatr Path 27:13–29

    Article  CAS  Google Scholar 

  180. Tan TYT, Sepulveda W (2003) Acardiac twin: a systematic review of minimally invasive treatment modalities. Ultrasound Obstet Gynaecol II 22:409–419

    Article  CAS  Google Scholar 

  181. Teramo KA, Widness JA (2008) Increased fetal plasma and amniotic fluid erythropoetin concentrations: markers of intrauterine hypoxia. Neonatology 95(2):105–116

    Article  PubMed  CAS  Google Scholar 

  182. Torpin R (1965) Amniochorionic mesoblastic fibrous strings and amnionic bands: associated contricting fetal malformations of fetal death. Am J Obstet Gynecol 91:65–75

    PubMed  CAS  Google Scholar 

  183. Trainor B, Tubman R (2006) The emerging pattern of hydrops fetalis-incidence, etiology, and management. Ulster Med J 75:185–186

    PubMed  CAS  Google Scholar 

  184. Turan S, Miller J et al (2008) Integrated testing and management in fetal growth restriction. Semin Perinatol 32:194–200

    Article  PubMed  Google Scholar 

  185. Venkatesha S, Toporsian M et al (2006) Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 12:642–649

    Article  PubMed  CAS  Google Scholar 

  186. Vernof K, Benirschke K et al (1992) Maternal floor infarction: Relation to X cells, major basic protein, and adverse perinatal outcome. Am J Obstet Gynecol 167:1355–1363

    PubMed  CAS  Google Scholar 

  187. Viscardi RM, Sun CC CC (2001) Placental lesion multiplicity: risk factor for IUGR and neonatal cranial ultrasound abnormalities. Early Hum Devel 62:1–10

    Article  CAS  Google Scholar 

  188. Waters BL, Ashikaga T (2006) Significance of perivillous fibrin/oid deposition in uterine evacuation specimens. Am J Surg Pathol 30:760–765

    Article  PubMed  Google Scholar 

  189. Weber MA, Nikkels PGJ et al (2006) Co-occurrence of massive perivillous fibrin deposition and chronic intervillositis: case report. Pediatr Dev Pathol 9:234–238

    Article  PubMed  Google Scholar 

  190. Wilkins-Haug L, Quade B et al (2006) Confined placental mosaicism as a risk factor among newborns with fetal growth restriction. Prenat Diagn 26:428–432

    Article  PubMed  Google Scholar 

  191. Wong AE, Sepulveda W (2005) Acardiac anomaly: current issues in prenatal assessment and treatment. Prenat Diagn 25:796–806

    Article  PubMed  Google Scholar 

  192. Wyatt S, Kraus FT et al (2005) The correlation between sampling site and gene expression in the term human placenta. Placenta 26:372–379

    Article  PubMed  CAS  Google Scholar 

  193. Yeruchimovich M, Dollberg S et al (1999) Nucleated red blood cells in infants of smoking mothers. Obstet Gynecol 93:403–406

    Article  PubMed  CAS  Google Scholar 

  194. Zhang J, Kraus FT et al (1985) Chorioamnionitis: a comparative histologic, bacteriologic, and clinical study. Int J Gynecol Pathol 4:1–10

    Article  PubMed  Google Scholar 

  195. Ziska Z, Fait T et al (2008) ABO fetomaternal compatibility poses a risk for massive fetomaternal transplacental hemorrhage. Acta Obstet Gynecol Scand 87:1011–1014

    Article  Google Scholar 

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Gersell, D.J., Kraus, F.T. (2011). Diseases of the Placenta. In: Kurman, R.J., Ellenson, L.H., Ronnett, B.M. (eds) Blaustein’s Pathology of the Female Genital Tract. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0489-8_19

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