Table of contents

  1. Tanja Eisenblaetter, Lenore Teichert, Ronald Burnette, Paul Hutson
  2. Lynne Hughes, Marie Trad, Stacey Boyer, Deborah Lee, Wei Yin
  3. Petar Nikolov, Georgi Banishki, Milena Nikolova-Vlahova
  4. Gulam Mohammed Husain, Mohammad Ahmed Khan, Mohd Urooj, Munawwar Husain Kazmi
  5. Smita Bhuyan, Sebastian Felgner, Dino Kocijancic, Vinay Pawar
  6. Jörg Schüttrumpf, Matthias Germer
  7. Pieter Siebenga, Pieter Okkerse, Guido van Amerongen, Robert Jan Doll, Alex Mentink, Justin Hay et al.
  8. Steven G. Woolfrey, James Gilmour Morrison
  9. Jens Atzrodt, Volker Derdau, Claudia Loewe
  10. Andrew McEwen

About this book


DDrug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined.

As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".

For the 2nd edition, all the existing chapters will be revised and completely updated. A large number of assays were added. New chapters were included, such as pain, addiction, gene therapy, orphan diseases etc. etc. The complete work was new arranged.


Assays drug action drugs clinical pharmacology pharmacodynamics pharmacokinetics

Editors and affiliations

  • Franz J. Hock
    • 1
  • Michael R. Gralinski
    • 2
  1. 1.CorDynamics DieburgGermany
  2. 2.CorDynamics ChicagoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing AG, part of Springer Nature 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Online ISBN 978-3-319-56637-5