Drug Discovery and Evaluation: Methods in Clinical Pharmacology

2011 Edition
| Editors: Hans Gerhard Vogel, Jochen Maas, Alexander Gebauer

Introduction

Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined.

As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".

Editors and affiliations

  • Hans Gerhard Vogel
    • 1
  • Jochen Maas
    • 2
  • Alexander Gebauer
    • 3
  1. 1.AalenGermany
  2. 2.Sanofi Aventis Deutschland GmbHIndustriepark HoechstFrankfurt am MainGermany
  3. 3.Merz Pharmaceuticals GmbHFrankfurt am MainGermany

Bibliographic information

  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • Print ISBN 978-3-540-89890-0
  • Online ISBN 978-3-540-89891-7
  • eBook Packages Biomedical and Life Sciences
  • Number Of Entries 39
  • About this book