Table of contents

  1. Front Matter
    Pages i-xlix
  2. Methods and Models for Studying Immunosenescence

    1. Front Matter
      Pages 1-1
    2. Elena Bianchini, Simone Pecorini, Sara De Biasi, Lara Gibellini, Milena Nasi, Andrea Cossarizza et al.
      Pages 3-38
    3. Thomas Ebensen, Kai Schulze, Blair Prochnow, Carlos Alberto Guzmán
      Pages 39-62
    4. Elena N. Naumova, Yuri N. Naumov, Jack Gorski
      Pages 63-124
    5. Andrea Rivera, Maham Rais, Tasha Barr, Nicole Arnold, Suhas Sureshchandra, Ilhem Messaoudi
      Pages 125-152
    6. Qing Yu, Jyoti Misra Sen, Dennis Daniel Taub
      Pages 153-176
    7. Graham Pawelec, Jürgen Kempf, Anis Larbi, Yvonne Barnett
      Pages 193-207
    8. A. A. Romanyukha, S. G. Rudnev, T. E. Sannikova, A. I. Yashin
      Pages 209-229
  3. Methods for Studying Human Immunosenescence in Tissues Other Than Blood

    1. Front Matter
      Pages 231-231
    2. Michelle Miron, Joseph J. C. Thome, Claire L. Gordon, Donna L. Farber
      Pages 233-257
    3. Beatrix Grubeck-Loebenstein, Luca Pangrazzi
      Pages 259-269
  4. Cellular Immunosenescence: T Cells

    1. Front Matter
      Pages 271-271
    2. Christine Bourgeois, Delphine Sauce
      Pages 273-301
    3. Claire E. Gustafson, David L. Lamar, Cornelia M. Weyand, Jörg J. Goronzy
      Pages 303-322
    4. Maha Almanan, Claire Chougnet, David A. Hildeman
      Pages 337-358
    5. Amanda A. Adams, David W. Horohov
      Pages 359-374
    6. Masanori Utsuyama, Yuko Yoshida-Kikuchi, Masanobu Kitagawa, Katsuiku Hirokawa
      Pages 375-393
    7. Nicole Noren Hooten, Dan L. Longo, Michele K. Evans
      Pages 395-424
    8. Patricia Griffin, Joshua J. Michel, Abbe N. Vallejo
      Pages 449-481
    9. Ewa Sikora, Agnieszka Brzezińska
      Pages 533-552
    10. Jaekwan Kim, Nan-ping Weng
      Pages 553-571
    11. Anna Wardowska, Piotr Trzonkowski
      Pages 573-603
  5. Cellular Immunosenescence: Antigen Presenting Cells

    1. Front Matter
      Pages 605-605
    2. Anshu Agrawal, Sudhanshu Agrawal, Sudhir Gupta
      Pages 607-621
    3. Lia Ginaldi, Massimo De Martinis
      Pages 623-650
    4. Silvia Della Bella
      Pages 651-671
    5. Karen Henriette Pinke, Heliton Gustavo de Lima, Vanessa Soares Lara
      Pages 673-688
    6. Marilyn Thoman, William Bray, Phyllis-Jean Linton
      Pages 689-710
    7. María Cristina Pistoresi-Palencia, María Florencia Harman, Sofía Daiana Castell
      Pages 711-731
    8. Michael J. Rauh, Elina K. Cook, Dawn M. E. Bowdish
      Pages 733-744
  6. Cellular Immunosenescence: B Cells

    1. Front Matter
      Pages 745-745
    2. Daniela Frasca, Richard L. Riley, Bonnie B. Blomberg
      Pages 747-758
    3. Jean L. Scholz, Yi Hao, William J. Quinn III, Michael P. Cancro
      Pages 759-783
    4. Deborah K. Dunn-Walters, Joselli Silva O’Hare
      Pages 785-819
    5. Matteo Bulati, Calogero Caruso, Giuseppina Colonna-Romano
      Pages 821-842
    6. Laura A. Vogel, Sarah Palackdharry, Laura M. Zimmerman, Rachel M. Bowden
      Pages 843-859
  7. Cellular Immunosenescence: Neutrophils

    1. Front Matter
      Pages 861-861
    2. Carl Fortin, Tamas Fulop, Anis Larbi, Gilles Dupuis
      Pages 891-906
    3. Janet M. Lord, Anna C. Phillips, Wiebke Arlt
      Pages 907-926
    4. Devin M. Boe, Michael M. Chen, Elizabeth J. Kovacs
      Pages 927-941
  8. Cellular Immunosenescence: NK and NKT Cells

    1. Front Matter
      Pages 943-943
    2. Carmen Campos, Alejandra Pera, María Luisa Pita-López, Nelson Lopez-Sejas, Fakhri Hassouneh, Beatriz Sánchez-Correa et al.
      Pages 945-965
    3. Savita Nair, Luis J. Sigal
      Pages 967-979

About this book


Immunosenescence is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”.


Immunosenescence Immunity T-cells Aging Age-associated pathologies Gerontology

Editors and affiliations

  • Tamas Fulop
    • 1
  • Claudio Franceschi
    • 2
  • Katsuiku Hirokawa
    • 3
  • Graham Pawelec
    • 4
  1. 1.Division of Geriatrics Research Center on AgingUniversity of Sherbrooke Department of MedicineSherbrookeCanada
  2. 2.Department of Experimental PathologyUniversity of BolognaBolognaItaly
  3. 3.Institute for Health and Life SciencesTokyoJapan
  4. 4.Center for Medical ResearchUniversity of TübingenTübingenGermany

Bibliographic information