Principles and Practice of Clinical Trials

  • Steven Piantadosi
  • Curtis L. Meinert
Living reference work

Table of contents

  1. O. Dale Williams, Katrina Epnere

About this book


This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the analysis and interpretation of scientific data gleaned from the trial process, a broad spectrum of clinical trial principles and practice areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy cannot be guaranteed and regulated without the Clinical Trials process. Because of an immense and continuing to grow international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time.

Principles in Practice of Clinical Trials is truly an interdisciplinary that will be divided into the following areas:

1) Clinical Trials Basic Perspectives
2) Regulation and Oversight
3) Basic Trial Designs
4) Advanced Trial Designs
5) Analysis
6) Trial Publication
7) Topics Related Specific Populations and Legal Aspects of Clinical Trials

The Work is designed to be comprised of 175 chapters and approximately 2500 pages. The Work will be oriented like many of our SpringerReference Handbooks, presenting detailed and comprehensive expository chapters on broad subjects. The Editors are major figures in the field of clinical trials, and both have written textbooks on the topic. There will also be a slate of 7-8 renowned associate editors that will edit individual sections of the Reference.


clinical trials clinical trial; design and analysis randomized clinical trials adaptive clinical trials data analysis biostatistics diagnostic trials screening trials observational studies

Editors and affiliations

  • Steven Piantadosi
    • 1
  • Curtis L. Meinert
    • 2
  1. 1.Samuel Oschin Comprehensive Cancer InstiWEST HOLLYWOODUSA
  2. 2.Bloomberg School of Public HealthJohns Hopkins Center for Clinical Trials Bloomberg School of Public HealthBaltimoreUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Mathematics and Statistics
  • Online ISBN 978-3-319-52677-5