Table of contents

  1. Front Matter
    Pages i-xv
  2. W. P. T. James
    Pages 1-30
  3. Antonio Giordano, Enzo Nisoli
    Pages 31-50
  4. Saverio Cinti
    Pages 51-74
  5. Lidia Castagneto Gissey, James Casella Mariolo, Geltrude Mingrone
    Pages 75-88
  6. Roberto Vettor, Scilla Conci
    Pages 89-108
  7. Gemma Xifra, José Maria Moreno-Navarrete, José Manuel Fernández-Real
    Pages 109-126
  8. Massimo Cuzzolaro
    Pages 127-150
  9. James D. Crane, Barbara M. McGowan
    Pages 151-177
  10. Paul Cordero, Jiawei Li, Jude A. Oben
    Pages 179-194
  11. Sviatlana Zhyzhneuskaya, Roy Taylor
    Pages 195-226
  12. Vasilios Kotsis, Christina Antza, Giannis Doundoulakis, Stella Stabouli
    Pages 227-241
  13. Ian W. Seetho, John P. H. Wilding
    Pages 243-271
  14. Lyn D. Ferguson, Naveed Sattar
    Pages 273-293
  15. Claudia K. Fox, Justin R. Ryder, Amy C. Gross, Aaron S. Kelly
    Pages 295-322
  16. R. Drew Sayer, James O. Hill
    Pages 323-348
  17. Vanessa Snowdon-Carr
    Pages 349-371
  18. Phong Ching Lee, John B. Dixon
    Pages 373-399
  19. Donna H. Ryan, Sarah R. Yockey
    Pages 401-424
  20. Werd Al-Najim, Carel W. le Roux
    Pages 425-434
  21. Back Matter
    Pages 435-440

About this book


This book presents the latest advances in our understanding of the pathophysiologic basis that induces the chronic positive energy balance necessary to progressively store excessive amounts of fat mass. It highlights the clinical complications of obesity, while also focusing on the major scientific advances that have highlighted the role of genetics, adipose tissue endocrinology and the environment in the mechanisms and causes of obesity. Particular attention is given to the consequences of obesity, including an ever -increasing number of other diseases such as type 2 diabetes, cardiovascular diseases and cancer, as well as conditions such as arthropathy, asthma, non-alcoholic liver disease, and dementia. Increasingly recognized uniting causes highlight the role of systemic, local and paracrine actions of adipocytokines in causing inflammation. As we come to better understand how hypothalamic control of energy balance is influenced by endocrine signaling from the gut and adipose tissue, it paves the way for new therapeutic targets and a resurgence of pharmacological and surgical approaches to treatment. 

Written by respected experts in the field, this volume is intended as a major reference source for endocrinologists, nutritionists, basic and clinical scientists alike.


Neuroendocrinology of energy balance Adipose organ Eating disorders Dietary treatment Pharmacological approaches Surgical approaches

Editors and affiliations

  • Paolo Sbraccia
    • 1
  • Nicholas Finer
    • 2
  1. 1.Department of Systems Medicine, Internal Medicine Unit and Obesity CenterUniversity of Rome Tor Vergata, University Hospital Policlinico Tor VergataRomeItaly
  2. 2.National Centre for Cardiovascular PreventionUniversity College LondonLondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Reference Module Medicine
  • Print ISBN 978-3-319-46932-4
  • Online ISBN 978-3-319-46933-1
  • Series Print ISSN 2510-1927
  • Series Online ISSN 2510-1935
  • Buy this book on publisher's site