Handbook of Neurochemistry and Molecular Neurobiology

Development and Aging Changes in the Nervous System

  • Abel Lajtha
  • J. Regino Perez-Polo
  • Steffen Rossner
Reference work

Table of contents

  1. Front Matter
    Pages i-xvi
  2. D. B. Pereira, M. V. Chao
    Pages 1-19
  3. L. A. Greene, J. M. Angelastro
    Pages 21-59
  4. Xiaoming Hu, J. R. Perez-Polo
    Pages 89-102
  5. V. Calabrese, D. A. Butterfield, A. M. Giuffrida Stella
    Pages 103-146
  6. X. Zhu, G. Casadesus, K. M. Webber, C. S. Atwood, R. L. Bowen, G. Perry et al.
    Pages 147-155
  7. E. Meshorer, H. Soreq
    Pages 215-243
  8. M. R. Kreutz, I. König, M. Mikhaylova, C. Spilker, W. Zuschratter
    Pages 245-259
  9. S. Roßner, S. F. Lichtenthaler
    Pages 261-284
  10. J. A. Joseph, J. R. Perez-Polo
    Pages 305-317
  11. Back Matter
    Pages 319-324

About this book


In the animal nervous system, a very high metabolic turnover, fragile but steep ionic gradients, and morphological and structural constraints - dictated by the necessity for prompt neuronal transmission of electrical impulses and necessary plasticity - result in a highly fragile organ system. Here, we address a small sampling of major constituents of neural function at the cellular and molecular level that play important roles in development and aging, two endogenous processes that embody features of allostasis or the dynamic shifts in set points for specific homeostatic mechanisms associated with development and aging. These chapters stress the dynamic features of neuronal responses to internal (developmental) cues or the more harmful external events (injury and disease) in a modern perspective.

Editors and affiliations

  • Abel Lajtha
    • 1
  • J. Regino Perez-Polo
    • 2
  • Steffen Rossner
    • 3
  1. 1.Center for NeurochemistryNathan S. Kline Institute for Psychiatric ResearchNew YorkUSA
  2. 2.Department of Biochemistry & Molecular BiologyUniversity of Texas Medical BranchGalvestonUSA
  3. 3.Universität Leipzig Medizinische FakultätPaul-Flechsig-Institut für HirnforschungLeipzigGermany

Bibliographic information