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Applications of Adenoviral Vector-Mediated Gene Transfer in Cardiovascular Research

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Cardiovascular Disease

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 129))

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Abstract

Cardiovascular disease is a leading cause of morbidity and mortality worldwide. New studies are needed to explore novel therapeutic options for patients that are refractory to existing therapies. Gene transfer using adenoviral vectors has shown promising results in animal studies, and is now being tested in many clinical trials. In this chapter, the advantages of adenoviral vector-mediated gene transfer for cardiovascular disease applications, and the methods on how to construct, propagate, and evaluate adenoviral vectors, are discussed.

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Authors and Affiliations

  1. Department of Pediatrics, Duke University Medical Center, Durham, NC

    Fang Xu, Delila Serra & Andrea Amalfitano

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  1. Fang Xu
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  2. Delila Serra
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  3. Andrea Amalfitano
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Editors and Affiliations

  1. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH

    Qing K. Wang PhD, MBA

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© 2006 Humana Press Inc.

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Xu, F., Serra, D., Amalfitano, A. (2006). Applications of Adenoviral Vector-Mediated Gene Transfer in Cardiovascular Research. In: Wang, Q.K. (eds) Cardiovascular Disease. Methods in Molecular Medicine, vol 129. Humana Press. https://doi.org/10.1385/1-59745-213-0:209

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  • DOI: https://doi.org/10.1385/1-59745-213-0:209

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-892-8

  • Online ISBN: 978-1-59745-213-7

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