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Experimental Models of Graft Arteriosclerosis

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Transplantation Immunology

Part of the book series: Methods In Molecular Biology™ ((MIMB,volume 333))

Abstract

Graft arteriosclerosis (GA) is the leading cause of mortality in long-term survivors of solid organ transplantation. Although clinical studies have suggested a multifactorial etiology, the precise mechanism of disease remains obscure. Many animal models have been developed that manifest lesions resembling those of human arteriosclerosis. These models have helped us address specific mechanistic and interventional issues but, for reasons that will be discussed, have failed to assign a unitary pathogenic mechanism to clinical GA. In this chapter we describe the commonly available experimental models of GA. We further discuss the merits and limitations of each model and outline their contribution to our understanding of the pathogenesis of the disease.

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Authors and Affiliations

  1. Cardiothoracic Surgery, National Heart and Lung Institute, London, England

    Bezhad Soleimani

  2. Transplantational Research, Novartis Pharmaceutical Corp., Summit, NJ

    Victor C. Shi

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  1. Bezhad Soleimani
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  2. Victor C. Shi
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Editor information

Editors and Affiliations

  1. National Heart and Lung Institute, London, UK

    Philip Hornick

  2. National Heart and Lung Institute, Harefield, UK

    Marlene Rose

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© 2006 Humana Press Inc.

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Soleimani, B., Shi, V.C. (2006). Experimental Models of Graft Arteriosclerosis. In: Hornick, P., Rose, M. (eds) Transplantation Immunology. Methods In Molecular Biology™, vol 333. Humana Press. https://doi.org/10.1385/1-59745-049-9:401

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  • DOI: https://doi.org/10.1385/1-59745-049-9:401

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-544-6

  • Online ISBN: 978-1-59745-049-2

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