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Synthesis of Linear, Branched, and Cyclic Peptide Chimera

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Book cover Peptide Synthesis and Applications

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 298))

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Abstract

Chimeric peptides are unnatural constructs consisting of bioactive compounds from at least two different peptide(s) and/or protein(s) or two sequences from differentparts of the same protein. Such multifunctional peptide combinations are prepared to enhance the biological activity or selectivity of their components. New biological effects can also be achieved with the chimera. In this chapter the synthesis of three different types of chimeric peptides will be described. In a linear chimera, two peptide epitopes from different parts of glycoprotein D (gD) of herpes simplex virus (HSV) are combined. A branched chimera, built from linear peptides, consists of tuftsin oligomers with immunostimulatory activity and an epitope peptide of HSV gD. The third compound is a cyclic chimeric molecule, where α-conotoxinGI as a host peptide is modified by the incorporation of a core epitope from HSV gD as a guest sequence.

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Author information

Authors and Affiliations

  1. Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Eötvös Loránd University, Budapest, Hungary

    Gábor Mezö

  2. Research Group of Peptide Chemistry, Department of Organic Chemistry, Hungarian Academy of Sciences, Eötvös Loránd University, Budapest, Hungary

    Ferenc Hudecz

Authors
  1. Gábor Mezö
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  2. Ferenc Hudecz
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Editor information

Editors and Affiliations

  1. Research Institute in Healthcare Science, School of Applied Sciences, University of Wolverhampton, Wolverhampton, UK

    John Howl

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© 2005 Humana Press Inc., Totowa, NJ

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Mezö, G., Hudecz, F. (2005). Synthesis of Linear, Branched, and Cyclic Peptide Chimera. In: Howl, J. (eds) Peptide Synthesis and Applications. Methods in Molecular Biology™, vol 298. Humana Press. https://doi.org/10.1385/1-59259-877-3:063

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  • DOI: https://doi.org/10.1385/1-59259-877-3:063

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-317-6

  • Online ISBN: 978-1-59259-877-9

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