Abstract
Recombinant adenoviral (rAd) vectors are highly suitable for efficient genetic modification of dendritic cells (DC). In certain cases, the high immunogenicity of rAd may be a disadvantage This chapter describes the essential aspects of optimal rAd-mediated gene transfer into DC, discusses the consequences of the immunogenicity of rAd vectors, and provides suggestions to minimize these complications.
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Offringa, R., Kwappenberg, K., Rabelink, M., Rea, D., Hoeben, R. (2005). Adenoviral Transduction of Dendritic Cells. In: Ludewig, B., Hoffmann, M.W. (eds) Adoptive Immunotherapy: Methods and Protocols. Methods in Molecular Medicineā¢, vol 109. Humana Press. https://doi.org/10.1385/1-59259-862-5:083
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DOI: https://doi.org/10.1385/1-59259-862-5:083
Publisher Name: Humana Press
Print ISBN: 978-1-58829-406-7
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