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A Survey of Venous Thrombosis Models

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Anticoagulants, Antiplatelets, and Thrombolytics

Part of the book series: Methods In Molecular Medicine™ ((MIMM,volume 93))

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Abstract

Animal models have played a crucial role in the development of new antithrombotic drugs during the past few decades. Through the use of these animal models, the differentiation between the anticoagulant and antithrombotic effects was first recognized. Drugs that were unable to produce a prolongation of blood clotting time were found to produce antithrombotic effects in animal models, and a recognition that endogenous effects in the intact animal resulting from the metabolic transformation of the drug and/or release of antithrombotic substances was appreciated. Without the use of intact animal models, such an observation would not have been possible.

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Author information

Authors and Affiliations

  1. Department of Thoracic-Cardiovascular Surgery, Loyola University Medical Center, Maywood, IL

    Walter P. Jeske

  2. Department of Pathology, Loyola University Medical Center, Maywood, IL

    Walter P. Jeske, Omer Iqbal & Jawed Fareed

  3. Cardiovascular Institute, Maywood, IL

    Walter P. Jeske

  4. Center for Vascular Biology and Medicine Erfurt, Friedrich Schiller University Jena, Erfurt, Germany

    Brigitte Kaiser

Authors
  1. Walter P. Jeske
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  2. Omer Iqbal
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  3. Jawed Fareed
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  4. Brigitte Kaiser
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Editor information

Editors and Affiliations

  1. Albany College of Pharmacy, Albany, NY

    Shaker A. Mousa

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© 2004 Humana Press Inc.

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Jeske, W.P., Iqbal, O., Fareed, J., Kaiser, B. (2004). A Survey of Venous Thrombosis Models. In: Mousa, S.A. (eds) Anticoagulants, Antiplatelets, and Thrombolytics. Methods In Molecular Medicine™, vol 93. Springer, Totowa, NJ. https://doi.org/10.1385/1-59259-658-4:221

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  • DOI: https://doi.org/10.1385/1-59259-658-4:221

  • Publisher Name: Springer, Totowa, NJ

  • Print ISBN: 978-1-58829-083-0

  • Online ISBN: 978-1-59259-658-4

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