Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics

  • William H. Hanneman
  • Melvin E. Andersen
  • Marie E. Legare
  • Christine T. French
  • Tami S. McMullin
  • Carolyn Broccardo
  • Ruth E. Billings
Part of the Methods in Pharmacology and Toxicology book series (MIPT)


Over the past decades, the risk assessment of chemicals has frequently been considered a pseudoscientific process, primarily determined by public policy that masquerades as science, rather than representing a process well grounded in firm biological principles. Many toxicologists are uncomfortable when their work is linked to risk assessment or even when asked how their work will influence the risk assessment process. This chapter discusses the integration of toxicological data in risk assessment, emphasizing the applications of molecular toxicology (toxicogenomics) for improving the risk assessments of all chemical especially neurotoxicants. The chapter discusses the integration of toxicology information via an exposure-dose paradigm, provides a brief synopsis of the emerging consensus to increase the scientific basis of “neuroactive” chemical risk assessment, and notes the areas where molecular toxicology will likely contribute to refinements of the current risk assessment process.


Risk Assessment Cancer Risk Assessment Risk Assessment Process Hazard Identification Molecular Toxicology 
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Copyright information

© Humana Press Inc., Totowa, NJ 2004

Authors and Affiliations

  • William H. Hanneman
    • 1
  • Melvin E. Andersen
    • 1
  • Marie E. Legare
    • 1
  • Christine T. French
    • 1
  • Tami S. McMullin
    • 1
  • Carolyn Broccardo
    • 1
  • Ruth E. Billings
    • 1
  1. 1.Department of Environmental and Radiological Sciences, College of Veterinary Medicine and Biomedical SciencesColorado State UniversityFt. Collins

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