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Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants

Enzyme Pathways in Neurons and Astroglia
  • Michael Aschner
  • Ursula Sonnewald
Protocol
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Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Abstract

In order to perform neurotoxicological studies, model systems have to be established and techniques developed to analyze relevant parameters. The present chapter describes the in vitro effects of the neurotoxicants aminooxyacetic acid (AOAA), 3-nitropropionic acid (3-NPA), and methylmercury (MeHg) on glial cell neurotransmitters, and for 3-NPA, we also describe the effects on cultured neurons. Major emphasis is directed at the effects of these compounds on glutamate metabolism.

Keywords

Cerebellar Granule Cell Pyruvate Carboxylase Cerebellar Granule Neuron Excitatory Amino Acid Transporter Glutamate Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc., Totowa, NJ 2004

Authors and Affiliations

  • Michael Aschner
    • 1
  • Ursula Sonnewald
    • 2
  1. 1.Department of Physiology and PharmacologyWake Forest University School of MedicineWinston-Salem
  2. 2.Department of Clinical NeuroscienceNorwegian University of Science and TechnologyTrondheimNorway

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