Abstract
During the last few years, a series of new detection methods in the field of biosensors have been developed. Biosensors are analytical devices that combine a biologically sensitive element with a physical or chemical transducer to selectively and quantitatively detect the presence of specific compounds in a given external environment.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Baselt, D. R., Lee, G. U., and Colton, R. J. (1996) Biosensor based on force microscope technology. Vacuum Sci. Technol. B 14, 789–793.
Masayuki, H., Yoshiaki, Y., Hideki, T., Hideo, O., Tsunenori, N., and Jun, M. (2002) A novel ISFET-type biosensor based on P450 monooxygenases Biosensors Bioelectronics 17, 173–179.
Fritz, J., Baller, M. K., Lang, H. P., et al. (2000) Translating biomolecular recognition into nanomechanics. Science 288, 316–318.
Berger, R., Delamarche, E., Lang, H. P., et al (1997) Surface stress in the self-assembly of alkanethiols on gold Science 276, 2021–2024.
Berger, R., Gerber, C. H., Gimzewski, J. K., Meyer, E. and Güntherodt, H.-J. (1996) Thermal analysis using a micromechanical calorimeter Appl. Phys. Lett. 69, 40–42.
Bachels, T., Schäfer, R., and Güntherodt, H.-J. (2000) Dependence of formation energies of tin nanoclusters on their size and shape Phys. Rev. Lett. 84, 4890–4893.
Baller, M. K., Lang, H. P., Fritz, J., et al. (2000) A cantilever array-based artificial nose Ultramicroscopy 82, 1–4.
Fritz J., Baller M. K., Lang H. P., et al. (2000) Stress at the solid-liquid interface of self-assembled monolayers on gold investigated with a nanomechanical sensor. Langmuir 16, 9694–9696.
Battiston F. M., Ramseyer J. P., Lang H. P., et al. (2001) A chemical sensor based on a microfabricated cantilever array with simultaneous resonance-frequency and bending readout. Sensors Actuators B 77, 122–131.
Wagner, P., Hegner, M., Kernen, P., Zaugg, F., and Semenza, G. (1996) N-hydroxysuccinimide ester functionalized self-assembled monolayers for covalent immobilization of biomolecules on gold. Biophys. J. 70, 2052–2066.
Stoney, G. G. (1909) The tension of metallic films deposited by electrolysis. Proc. R. Soc. London Soc. A 82, 172–175.
McKendry, R., Strunz, T., Arntz, Y., et al. (2002) Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array. Proc. Natl. Acad. Sci. USA 99, 9783–9788.
Arntz, Y., Seelig, J.E., Zhang, J., et al. (2003) A label-free protein assay based on a nanomechanical cantilever array. Nanotechnology 14, 86–90.
Thaysen J., Marie R., and Boisen A. (2001) Cantilever-based bio-chemical sensor integrated in a microfluidic handling system, in IEEE Int. Conf. Micro. Electro. Mech. Syst., Tech. Dig. Institute of Electrical and Electronic Engineers, New York, 14th, pp. 401–404.
Hansen, K. M., Ji, H. F., Wu, G. H., et al. (2001) Cantilever-based optical deflection assay for discrimination of DNA single-nucleotide mismatches. Anal. Chem. 73, 1567–1571.
Wu, G. H., Datar, R. H., Hansen, K. M., Thundat, T., Cote, R. J., and Majumdar, A. (2001) Bioassay of prostate-specific antigen (PSA) using microcantilevers. Nat. Biotech. 19, 856–860.
Grogan, C., Raiteri, R., O’Connor, G. M., et al. (2001) Characterisation of an antibody coated microcantilever as a potential immuno-based biosensor. Biosens. Bioelectron. 17, 201–207.
Lang, H.P., Hegner, M., Meyer, E and Christoph Gerber (2002) Nanomechanics from atomic resolution to molecular recognition based on atomic force microscopy technology. Nanotechnology 13, R29–R36.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Humana Press Inc., Totowa, NJ
About this protocol
Cite this protocol
Hegner, M., Arntz, Y. (2004). Advanced Biosensing Using Micromechanical Cantilever Arrays. In: Braga, P.C., Ricci, D. (eds) Atomic Force Microscopy. Methods in Molecular Biology™, vol 242. Humana Press. https://doi.org/10.1385/1-59259-647-9:39
Download citation
DOI: https://doi.org/10.1385/1-59259-647-9:39
Publisher Name: Humana Press
Print ISBN: 978-1-58829-094-6
Online ISBN: 978-1-59259-647-8
eBook Packages: Springer Protocols