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Side Effects of Suicide Gene Therapy

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Suicide Gene Therapy

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 90))

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Abstract

The efficacy of standard chemotherapy tends to be limited by an inability to achieve sufficiently high drug concentrations to tumor cells without inducing concomitant toxicity elsewhere. If the tumor itself were induced to produce the drug, the efficacy would be increased. This strategy can be achieved by installing in tumor cells a gene that can activate a harmless prodrug into a cytotoxic drug. The premise is that activation of prodrugs in or near the tumor would lead locally to a high concentration of the toxic drug.

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Authors and Affiliations

  1. Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands

    Marjolijn M. van der Eb, Bertie de Leeuw, Alex J. van der Eb & Rob C. Hoeben

  2. Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands

    Marjolijn M. van der Eb

  3. Department of Neuro-Oncology, Erasmus University, Rotterdam, The Netherlands

    Bertie de Leeuw

  4. Department of Radiation Genetics, Leiden University Medical Center, Leiden, The Netherlands

    Alex J. van der Eb

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  1. Marjolijn M. van der Eb
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  2. Bertie de Leeuw
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  3. Alex J. van der Eb
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  4. Rob C. Hoeben
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Editors and Affiliations

  1. Cancer Research UK Centre for Cancer Therapeutics at the Institute of Cancer Research, Sutton, Surrey, UK

    Caroline J. Springer

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van der Eb, M.M., de Leeuw, B., van der Eb, A.J., Hoeben, R.C. (2004). Side Effects of Suicide Gene Therapy. In: Springer, C.J. (eds) Suicide Gene Therapy. Methods in Molecular Medicine™, vol 90. Humana Press. https://doi.org/10.1385/1-59259-429-8:479

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  • DOI: https://doi.org/10.1385/1-59259-429-8:479

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-971-1

  • Online ISBN: 978-1-59259-429-0

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