Abstract
Synaptosomal protein oxidation, most often indexed by increased protein carbonyl content (1,2), is one biomarker of oxidative stress in brain (2). Protein carbonyls are detected by UV-Vis spectrometric, fluorescence, or immunochemical methods (2), and are increased in a variety of oxidative stress disorders of the brain. Among the latter are Alzheimer’s disease (AD) (3) and animal models of AD (4), Huntington’s disease (HD) (5,6), and accelerated aging (7).
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Butterfield, D.A. (2003). Electron Paramagnetic Resonance Spin-Labeling Analysis of Synaptosomal Membrane Protein Oxidation. In: Hensley, K., Floyd, R.A. (eds) Methods in Biological Oxidative Stress. Methods in Pharmacology and Toxicology. Humana Press. https://doi.org/10.1385/1-59259-424-7:79
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DOI: https://doi.org/10.1385/1-59259-424-7:79
Publisher Name: Humana Press
Print ISBN: 978-0-89603-815-8
Online ISBN: 978-1-59259-424-5
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