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Hematopoietic Stem and Progenitor Cells

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Lentivirus Gene Engineering Protocols

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 229))

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Abstract

There has been much effort in isolating hematopoietic stem cells (HSC) and some confusion within the literature on what even a HSC is, with some investigators using the term inappropriately (1). A HSC is a cell capable of both self-renewal and of deriving progeny of all hematopoietic cell lineages, that is, a single HSC can regenerate erythroid, myeloid, megakaryocytic, and lymphoid lineages in a myeloablated host. Progenitor cells, on the other hand, are cells committed to one or a few lineages having a limited capacity for self-renewal. Progenitors are the progeny of HSC.

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Author information

Authors and Affiliations

  1. Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, MD

    Robert E. Donahue

  2. UCLA AIDS Institute, School of Medicine, Los Angeles, CA

    Irvin S. Y. Chen

Authors
  1. Robert E. Donahue
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  2. Irvin S. Y. Chen
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Editor information

Editors and Affiliations

  1. Laboratory of Virology, Istituto Superiore di Sanitá, Rome, Italy

    Maurizio Federico

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© 2003 Humana Press Inc.

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Donahue, R.E., Chen, I.S.Y. (2003). Hematopoietic Stem and Progenitor Cells. In: Federico, M. (eds) Lentivirus Gene Engineering Protocols. Methods in Molecular Biology™, vol 229. Humana Press. https://doi.org/10.1385/1-59259-393-3:117

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  • DOI: https://doi.org/10.1385/1-59259-393-3:117

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-091-5

  • Online ISBN: 978-1-59259-393-4

  • eBook Packages: Springer Protocols

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