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Use of Radionuclides to Study Renal Function

Protocol
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 86)

Abstract

Radionuclides have been used to study renal function clinically since the introduction of the radioisotope renogram by Taplin (1) and Kimball (2). This use is mainly directed at the excretory functions of the kidney that involve glomerular filtration and tubular secretion. Glomerular filtration is a process that may be quantified by the measurement of the rate of renal clearance of a particular substance in the blood. The indicator must meet the following criteria: i) free filtration through the glomerular capillary membranes; ii) no secretion or absorption by the renal tubules; iii) no metabolism by the kidney; iv) no binding to plasma proteins; v) nontoxic and inert; and vi) measurable with high accuracy. Radiochemical purity is an additional requirement when radiolabeled agents are used.

Keywords

Positron Emission Tomography Glomerular Filtration Rate Positron Emission Tomography Imaging Renal Blood Flow Effective Renal Plasma Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Humana Press Inc., Totowa, NJ 2003

Authors and Affiliations

  1. 1.Department of Nuclear MedicineMontefiore Medical CenterBronx
  2. 2.Department of Nuclear MedicineAlbert Einstein College of Medicine and Montefiore Medical CenterBronx

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