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Particle-Mediated Gene Therapy of Wounds

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Wound Healing

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 78))

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Abstract

Advances in molecular biology and the understanding of the molecular basis of many diseases have provided tools necessary for a new approach to the treatment of both inherited and acquired diseases. This approach, called gene therapy, was initially focused on the correction of inherited diseases for which no therapeutic approaches were available (1,2). However, it is now clear that the technique of gene therapy can potentially be applied to the local, temporary treatment of acquired diseases, including impaired wound healing and tissue repair (3). Gene therapy is becoming a reality, and it is a particularly attractive approach for wound healing, since the wound site is often exposed, the treatment and condition should be transient, and gene products such as growth factors and cytokines suffer from problems with bioavailability and stability. Such approaches are often innovative and provide solutions to the problems inherent in cell-based drug delivery methods.

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Author information

Authors and Affiliations

  1. Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN

    Jeffrey M. Davidson & Jayasri Dasgupta

  2. Department of Veterans Affairs Medical Center, Nashville, TN

    Jeffrey M. Davidson

  3. Department of Dermatology, Cologne University, Cologne, Germany

    Sabine A. Eming

Authors
  1. Jeffrey M. Davidson
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  2. Sabine A. Eming
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  3. Jayasri Dasgupta
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Editor information

Editors and Affiliations

  1. Department of Surgery, Burn and Shock Trauma Institute, Loyola University Medical Center, Maywood, IL

    Luisa A. DiPietro  & Aime L. Burns  & 

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© 2003 Humana Press Inc., Totowa, NJ

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Davidson, J.M., Eming, S.A., Dasgupta, J. (2003). Particle-Mediated Gene Therapy of Wounds. In: DiPietro, L.A., Burns, A.L. (eds) Wound Healing. Methods in Molecular Medicine™, vol 78. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-332-1:433

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  • DOI: https://doi.org/10.1385/1-59259-332-1:433

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-999-5

  • Online ISBN: 978-1-59259-332-3

  • eBook Packages: Springer Protocols

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