Abstract
Resistance to chemotherapy is a major source of failure in cancer treatment. A large number of cancers are intrinsically resistant to cytostatic agents; others initially respond to treatment, but subsequently develop a resistance to the drugs being used. Of the human solid malignancies, small cell lung carcinomas (SCLCs) are among the most chemosensitive and radiosensitive tumors, with most of them responding to initial therapy. However, the majority not only will recur but will remain largely refractory to further treatment. Most non-small cell lung carcinomas (NSCLCs) are primarily resistant to therapy; it is rare to obtain a complete response.
Keywords
- Vascular Endothelial Growth Factor
- Proliferate Cell Nuclear Antigen
- Apoptotic Index
- Dihydrofolate Reductase
- Small Cell Lung Carcinoma
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 2003 Humana Press Inc., Totowa, NJ
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Volm, M., Koomägi, R., Rittgen, W. (2003). Cellular Predictive Factors of Drug Resistance in Non-Small Cell Lung Carcinomas. In: Driscoll, B. (eds) Lung Cancer. Methods in Molecular Medicine™, vol 75. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-324-0:39
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DOI: https://doi.org/10.1385/1-59259-324-0:39
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-0-89603-920-9
Online ISBN: 978-1-59259-324-8
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