Abstract
Abnormalities in mucin-type glycoprotein expression have been documented in a variety of cancers, identifying these molecules as targets for immunologically based therapies and prognostic/diagnostic assays. Epithelial mucin proteins are synthesized by cells lining the ducts and lumens of various epithelial surfaces and contribute to the protective and lubricating functions of mammalian mucus (1). These proteins are characterized by a variable number of amino acid tandem repeats and extensive O-glycosylation at serine and threonine residues, resulting in a composition of 50-80% carbohydrate by weight. To date, at least 9 mucin genes, encoding the protein backbone of these glycoproteins, have been identifi ed and at least partially sequenced.
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Ā© 2003 Humana Press Inc., Totowa, NJ
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Szabo, E. (2003). MUC1 Expression in Lung Cancer. In: Driscoll, B. (eds) Lung Cancer. Methods in Molecular Medicineā¢, vol 74. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-323-2:251
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DOI: https://doi.org/10.1385/1-59259-323-2:251
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-0-89603-985-8
Online ISBN: 978-1-59259-323-1
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