Generation of Monoclonal Antibodies Against Secreted Proteins of STEC

Abstract

Bacterial pathogens have evolved a variety of strategies to hijack the host cell signaling systems, membrane trafficking events, as well as the cytoskeletal machinery, and the discovery of these strategies has contributed significantly to recent advances in cell biology. The relatively new scientific discipline “cellular microbiology” focuses on the moleular crosstalk between pathogens and their host cells, as the elucidation of these interactions not only helps to understand the molecular basis of disease but has also given rise to new model systems for probing host cell functions.