Abstract
Combinatorial methods have been applied with a measure of success in the field of metal ion coordination chemistry (1–5). High-throughput screening methods have been used to facilitate the discovery of new catalysts and to design ligands for binding metal ions (6–9). Metal ion coordination complexes have been central to the development of dynamic combinatorial methods as well. Dynamic combinatorial methods utilize a library whose composition is con-trolled through reversible interactions with a target molecule (10,11). Metalligand bonds are often labile enough to undergo reversible bond formation under mild conditions, making metal ions ideal components for dynamic librar-ies. Such metal ion complexes are used in dynamic combinatorial libraries for the purpose of designing compounds with unusual shapes or recognition properties (12,13).
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References
Still W. C., Hauck P., and Kempf D. (1987) Stereochemical studies of lasalocid epimers. Ion-driven epimerizations. Tetrahedron Lett. 28, 2817–2820.
Hasenknopf B., Lehn J.-M., Kneisel B. O., Baum G., and Fenske D. (1996) Self-assembly of a circular double helicate. Angew. Chem. Int. Ed. Engl. 35, 1838–1840.
Hill C. L. and Zhang X. (1995) A smart catalyst that self-assembles under turn-over conditions. Nature 373, 324–326.
Huc I., Krische M. J., Funeriu D. P., and Lehn J.-M. (1999) Dynamic combina-torial chemistry: substrate H-bonding directed assembly of receptors based on bipyridine-metal complexes. Eur. J. Inorg. Chem., 1415–1420.
Albrecht M., Blau O., and Frohlich R. (1999) An expansible metalla-cryptand as a component of a supramolecular combinatorial library formed from Di(8-hydrox-yquinoline) ligands and gallium (III) or zinc (II) ions. Chem. Eur. J. 5, 48–56.
Burger M. T. and Still W. C. (1995) Synthetic ionophores. Encoded combi-natorial libraries of cyclen-based receptors for Cu2+ and Co2+. J. Org. Chem. 60, 7382–7383.
Francis M. B., Finney N. S., and Jacobsen E.N. (1996) Combinatorial approach to the discovery of novel coordination complexes. J. Am. Chem. Soc. 118, 8983–8984.
Hoveyda A. H. (1998) Catalyst discovery through combinatorial chemistry. Chem. Bio. 5, R187–R191.
Francis M. B., Jamison T. F., and Jacobsen E.N. (1998) Combinatorial libraries of transition-metal complexes, catalysts and materials. Curr. Opion. Chem. Bio. 2, 422–428.
Lehn J. M. (1999) Dynamic combinatorial chemistry and virtual combinatorial libraries. Chem. Eur. J. 5, 2455–2463.
Goral V., Nelen M., Eliseev A. V., and Lehn J.-M. (2001) Double-level “orthogo-nal” dynamic combinatorial libraries on transition metal template. Proc. Natl. Acad. Sci. 98, 1347–1352.
Klekota B., Hammond M. H., and Miller B. L. (1997) Generation of novel DNA-binding compounds by selection and amplification from self-assembled combina-torial libraries. Tetrahedron Lett. 38, 8639–8642.
Goodman M. S., Jubian V., Linton B., and Hamilton A. D. (1995) A combinatorial library approach to artificial receptor design. J. Am. Chem. Soc. 117, 11610–11611.
Yordanov A. and Roundhill M. (1998) Solution extraction of transition and post-transition heavy and precious metals by chelate and macrocyclic ligands. Coord. Chem. Rev. 170, 93–124.
Nash K. L. and Choppin G. R. (1997) Separations chemistry for actinide ele-ments: recent developments and historical perspective. Separation Science and Technology 32, 255–274.
Rydberg J., Musikas C., and Choppin G. R. (eds.) (1992) Principles and Prac-tices of Solvent Extraction, Marcel Dekker, New York.
Cox B. G. and Schneider H. (1992) Coordination and Transport Properties of Macrocyclic Compounds in Solution, Elsevier, New York.
Epstein D. M., Choudhary S., Churchill M. R., Keil K. M., Eliseev A. V., and Morrow J. R. (2001) Chloroform-soluble Schiff-base Zn(II) or Cd(II) complexes from a dynamic combinatorial library Inorg. Chem. 40, 1591–1596.
Gillard R. D. and McCleverty J. A. (eds.) (1987) Zinc and cadmium, In Compre-hensive Coordination Chemistry, 1st ed, Pergamon Press, Oxford, England, vol. 5, p. 940.
Cheng K. L., Veno K., and Imammura T. Handbook of Organic and Analytical Reagents, CRC Press, Inc., Boca Raton, FL, 1982.
Epstein D. M. (2000) Cleavage of phosphodiesters and 5'-CAP of m-RNA by lanthanide (II) macrocyclic complexes and the selection of Schiff-base transition metal complexes from a dynamically generated combinatorial library Ph.D. The-sis, State University of New York at Buffalo.
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Choudhary, S., Morrow, J.R. (2002). Ligand Libraries for the Extraction of Metal Ions. In: English, L.B. (eds) Combinatorial Library. Methods in Molecular Biology™, vol 201. Springer, Totowa, NJ. https://doi.org/10.1385/1-59259-285-6:215
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DOI: https://doi.org/10.1385/1-59259-285-6:215
Publisher Name: Springer, Totowa, NJ
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