Abstract
Nitric oxide (NO) and the related species nitrosothiols, have multiple important physiological and pathological roles in health and disease that have been extensively reviewed elsewhere (1-6). In brief, NO is involved in modulating or mediating host resistance to tumors and microbes, regulation of blood pressure and vascular tone, neurotransmission, learning, neurotoxicity, and control of cellular growth, and differentiation.
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References
Bogdan, C. (1998) The multiplex functions of nitric oxide in (auto)immunity. J. Exp. Med. 187, 1361ā1365.
Fang, F. C. (1997) Mechanisms of nitric oxide-related antimicrobial activity. J. Clin. Invest. 99, 2818ā2825.
Moncada, S. and Higgs, A. (1993) The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329, 2002ā2012.
Moncada, S. and Higgs, E. A. (1995) Molecular mechanisms and therapeutic strategies related to nitric oxide [review]. FASEB J. 9, 1319ā1330.
Nathan, C. and Xie, Q. W. (1994) Nitric oxide synthases-Roles, tolls, and controls. Cell 78, 915ā918.
Weinberg, J. (1998) Nitric oxide production and nitric synthase type 2 expression by human mono-nuclear phagocytes: a review. Mol. Med. 4, 557ā591.
Anstey, N. M., Weinberg, J. B., Hassanali, M. Y., Mwaikambo, E. D., Manyenga, D., Misukonis, M. A., et al. (1996) Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J. Exp. Med. 184, 557ā567.
Kosaka, H. K., Imaizumi, K., Imai, K., and Tyuma, I. (1979) Stoichiometry of the reaction of oxy-hemoglobin with nitrite. Biochim. Biophys. Acta. 581, 184ā188.
Westfelt, U. N., Benthin, G., Lundin, S., Stenqvist, O., and Wennmalm, A. (1995) Conversion of inhaled nitric oxide to nitrate in man. Br. J. Pharmacol. 114, 1621ā1624.
Agbenyega, T., Angus, B., Bedu-Addo, G., Baffoe-Bonnie, B., Griffin, G., Vallance, P., et al. (1997) Plasma nitrogen oxides and blood lactate concentrations in Ghanaian children with malaria. Trans. R. Soc. Trop. Med. Hyg. 91, 298ā302.
Al Yaman, F. M., Mokela, D., Genton, B., Rockett, K. A., Alpers, M. P., and Clark, I. A. (1996) Association between serum levels of reactive nitrogen intermediates and coma in children with cerebral malaria in Papua New Guinea. Trans. R. Soc. Trop. Med. Hyg. 90, 270ā273.
Cot, S., Ringwald, P., Mulder, B., Miailhes, P., Yap-Yap, J., Nussler, A. K., et al. (1994) Nitric oxide in cerebral malaria. J. Infect. Dis. 169, 1417,1418.
Kremsner, P. G., Winkler, S., Wildling, E., Prada, J., Bienzle, U., Graninger, W., and Nussler, A. K. (1996) High plasma levels of nitrogen oxides are associated with severe disease and correlate with 467 rapid parasitological and clinical cure in Plasmodiumfalciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 90, 44ā47.
Nussler, A. K., Eling, W., and Kremsner, P. G. (1994) Patients with Plasmodiumfalciparum malaria and Plasmodium vivax malaria show increased nitrite and nitrate plasma levels. J. Infect. Dis. 169, 1418,1419.
Prada, J. and Kremsner, P. G. (1995) Enhanced production of reactive nitrogen intermediates in human and murine malaria. Parasitol. Today 11, 409,410.
Anonymous (1981) Nitrate, nitrite and nitrogen oxides: environmental distribution and exposure of humans, in The Health Effects of Nitrate, Nitrite, and N-Nitroso Compounds, vol. 1. (Peter, F. M., ed.), National Academy Press, Washington, DC, pp. 3ā52.
Granger, D., Anstey, N., Miller, W., and Weinberg, J. (1999) Measuring nitric oxide production in human clinical studies. Meth. Enzymol. 301, 49ā61.
Mitchell, H. H., Shonle, H. A., and Grindley, H. S. (1916) The origin of nitrates in the urine. J. Biol. Chem. 24, 461ā490.
Anstey, N. M., Granger, D. L., and Weinberg, J. B. (1997) Nitrate levels in malaria. Trans. R. Soc. Trop. Med. Hyg. 91, 238ā240.
Mackenzie, I. M. J., Ekangaki, A., Young, J. D., and Garrard, C. S. (1996) Effect of renal function on serum nitrogen oxide concentrations. Clin. Chem. 42, 440ā444.
Makela, S., Yazdanpanah, M., Adatja, I., and Ellis, G. (1997) Disposable surgical gloves and Pas-teur (Transfer) pipettes as potential sources of contamination in nitrite and nitrate assays. Clin. Chem. 43, 2418.
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Anstey, N.M., Boutlis, C.S., Saunders, J.R. (2002). Systemic Nitric Oxide Production in Human Malaria. In: Doolan, D.L. (eds) Malaria Methods and Protocols. Methods in Molecular Medicineā¢, vol 72. Humana Press. https://doi.org/10.1385/1-59259-271-6:461
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DOI: https://doi.org/10.1385/1-59259-271-6:461
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