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Peptide Vaccination

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Book cover Malaria Methods and Protocols

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 72))

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Abstract

Vaccination is the most cost-effective measure to control the pathological effects of an infectious agent (1,2). With the combined use of molecular cloning and of modern sequencing methods, the sequence of many protein components present in different infectious agents have been elucidated, opening the way to the design and development of various vaccination strategies which include peptides, proteins and DNA. Peptide vaccination is per se the most simple, straightforward, and, in our opinion, safest approach to vaccination of the world population. For peptide, we intend protein fragments of any length obtained from chemical synthesis (3-5). One drawback of using short peptides is the limitation of the intervention to defined members of the population that carry the major histocompatibility complex (MHC) antigen(s) which the peptides bind to (MHC restriction). This limitation can, in principle, be overcome by using a physical or chemical mixture of short peptides or to lengthen the size of the peptide fragment in order to cover the MHC antigens of the entire population (6,7).

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Author information

Authors and Affiliations

  1. Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland

    Valentin Meraldi, Jackeline F. Romero & Giampietro Corradin

Authors
  1. Valentin Meraldi
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  2. Jackeline F. Romero
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  3. Giampietro Corradin
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Editor information

Editors and Affiliations

  1. Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA

    Denise L. Doolan

  2. Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD, USA

    Denise L. Doolan

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© 2002 Humana Press Inc.

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Meraldi, V., Romero, J.F., Corradin, G. (2002). Peptide Vaccination. In: Doolan, D.L. (eds) Malaria Methods and Protocols. Methods in Molecular Medicine™, vol 72. Humana Press. https://doi.org/10.1385/1-59259-271-6:335

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  • DOI: https://doi.org/10.1385/1-59259-271-6:335

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-823-3

  • Online ISBN: 978-1-59259-271-5

  • eBook Packages: Springer Protocols

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