Abstract
DNA topoisomerase I (topo I) has been firmly established as the molecular target of the camptothecin group of anticancer drugs. These drugs include camptothecin, topotecan, 9-amino-camptothecin, and irinotecan (1). Many of them are now in clinical trials and are showing activity against a wide variety of solid human malignancies (2).
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© 1999 Humana Press Inc.
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Holden, J.A. (1999). Purification of DNA Topoisomerase I from Human Placenta. In: Bjornsti, MA., Osheroff, N. (eds) DNA Topoisomerase Protocols. Methods in Molecular Biology, vol 94. Humana, Totowa, NJ. https://doi.org/10.1385/1-59259-259-7:213
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DOI: https://doi.org/10.1385/1-59259-259-7:213
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