Abstract
Tau was originally isolated from brain microtubules and shown to be a microtubule-associated protein (MAP) that promoted tubulin polymerization (1). It is largely confined to axons, where it is the major MAP. It promotes microtubule nucleation, elongation, and bundling, and stabilizes microtubules by inhibiting depolymerization.
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Reynolds, C., Gibb, G.M., Lovestone, S. (2000). Tau Phosphorylation Both In Vitro and in Cells. In: Hooper, N.M. (eds) Alzheimer's Disease. Methods in Molecular Medicineā¢, vol 32. Humana Press. https://doi.org/10.1385/1-59259-195-7:375
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DOI: https://doi.org/10.1385/1-59259-195-7:375
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