Abstract
The specificity, homogeneity, and availability of large-batch production of liposomes with natural lipids and synthetic lipids have made them an extremely useful tool for the study of diverse cellular phenomena, as well as in medical applications. In many cases, however, the success of the use of liposomes as drug carriers or vaccines and in gene delivery depends entirely on both their formulation and the method of preparation.
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References
Gregoriadis G., ed. (1993) Liposome Technology, vols. I, II, III, 2nd edit. CRC Press, Boca Roton, FL.
Lasic D. D. and Paphadjopoulus D., eds. (1998) Medical Applications of Liposomes. Elsevier, New York, NY.
Lasic D. D., ed. (1997) Liposomes in Gene Delivery. CRC Press, Boca Raton, FL.
Alvin C. R. and Sivartz G. M., Jr. (1984) Liposome Techology, vol. II. CRC Press, Boca Raton, FL, pp. 55–69.
Szoda F. C. and Papahadjopoulos D. (1981) Liposomes: preparation and characterization, in Liposomes: From Physical Structure to Therapeutic Application (Knight C. G., ed.), Elsevier, Amsterdam, pp. 51–82.
Payne N. L., Browning I., and Haynes C. A. (1986) Characterization of Proliposomes. J. Pharmaceut. Sci. 75, 330–333.
Saunders L., Perrin J., and Gammack D. B. (1962) Ultrasonic irradiation of some phospholipids sols. J. Pharmaceut. Pharmacol. 14, 567–572.
Huang C. H. (1969) Studies on phosphatidylcholine vesicles. Formation and physical characteristics. Biochemistry 8, 344–351.
Bangham A. D., Hill M. W., and Miller G. A. (1974) Preparation and use of liposomes as models of biological membranes, in Methods in Membrane Biology (Korn E. D., ed.), Plenum. Press, New York, pp. 1–68.
Deamer D. and Bangham A. D. (1976) Large volume liposomes by an ether vaporization method. Biochim. Biophys. Acta 443, 629–634.
Cafiso D. S., Petty F. R., and McConnell H. M. (1981) Preparation of unilamellar vesicles at 37°C by vaporization methods. Biochim. Biophys. Acta 649, 129–132.
Hauser H. and Grains N. (1982) Spontaneous vesiculation of phospholipids: a simple and quick method of forming unilamellar vesicles. Proc. Natl. Acad. Sci. USA 79, 1683–1687.
Enouch H. G. and Strittmatter P. (1979) Formation and properties of 1000-Aodiameter, single-bilayer phospholipid vesicles. Proc. Natl. Acad. Sci USA 76, 146–149.
Hope M. J., Bally M. B., Webb G., and Cullis P. R. (1985) Production of large unilamellar vesicles by a rapid extrusion procedure: characterization of size distribution and ability to maintain a membrane potential. Biochim. Biophys. Acta 812, 55–65.
Chatterjee S., Sekerk C. S., and Kwiterovich P. O. (1982) Increased urinary excretion of glycosphingolipids in familial hypercholesterolemia. J. Lipid Res. 23, 513–522.
Esselman W. J., Laine R. A., and Sweeley C. C. (1972) Methods in Enzymology, vol. 28, Part B, Academic Press, New York, pp. 140–156.
Ledeen R. W. and Yu R. K. (1982) Ganglioside Structure, Isolation and Analysis. Methods in Enzymology, vol. 83, Part D, 139–191.
Krupp L., Chobanian A. V., and Brecher J. P. (1976) The in vivo transformation of phospholipid vesicles to a particle resembling HDL in the rat. Biochem. Biophys. Res. Commun. 72, 1251–1258.
Senior J., Gregoriadis G., and Mitropoulous K. A. (1983) Stability and clearance of small unilamellar liposomes. Studies with normal and lipoprotein-deficient mice. Biochim. Biophys. Acta 760, 111–118.
Tall A. R. and Small D. M. (1977) Solubilization of phospholipid membranes by human plasma high density lipoproteins. Nature (Lond.) 265, 163–164.
Vitas A. I., Diaz R., and Gamazo C. (1996) Effect of composition and method of preparation of liposomes on their stability and interaction with murine monocytes infected with Brucella abortus. Antimicrob. Agents Chemother. 40, 146–151.
Papahadjopoulos D. and Watkins J. C. (1967) Phospholipid model membranes II. Permeability properties of hydrated liquid crystals. Biochim. Biophys. Acta 135, 639–652.
Gruner S. M., Lenk R. P., Janoff A. S., and Ostro M. J. (1985) Novel multilayered lipid vesicles. Comparison of physical characteristics of multilamellar liposomes and stable plurilamellar vesicles. Biochemistry 24, 2833–2842.
Chatterjee S. (1994) Neutral sphingomyelinase action induces signal transduction of tumor necrosis factor in increasing cholesteryl ester synthesis in human fibroblasts. J. Biol. Chem. 269, 879–882.
Jungalwala F. B., Ullman M. D. and McCluer R. H. (1987) High performance liquid chromatography of glycosphingolipids in brain disease. J. Chromatogr. 32, 348–377.
Chatterjee S. and Yanni S. (1987) Analysis of neutral glycosphinoglipids and sulfatides by high performance liquid chromatography. LC-GC 5, 571–574.
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Chatterjee, S., Banerjee, D.K. (2002). Preparation, Isolation, and Characterization of Liposomes Containing Natural and Synthetic Lipids. In: Basu, S.C., Basu, M. (eds) Liposome Methods and Protocols. Methods in Molecular Biology, vol 199. Humana Press. https://doi.org/10.1385/1-59259-175-2:03
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DOI: https://doi.org/10.1385/1-59259-175-2:03
Publisher Name: Humana Press
Print ISBN: 978-0-89603-845-5
Online ISBN: 978-1-59259-175-6
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