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Coagulation Studies

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Meningococcal Disease

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 67))

Abstract

Disseminated intravascular coagulation (DIC) is a complex acquired, coagulopathy resulting from excessive thrombin formation. Abnormal tissue factor (TF) expression is a major mechanism initiating DIC in many disorders, including obstetric complications, sepsis, cancer, and trauma. Numerous laboratory tests are available to monitor DIC, but most patients can be adequately managed using only routine hemostasis screening tests, and assays for fibrinogen and D-dimers. Treatment of DIC should focus on reversing the underlying disorder that initiated the coagulopathy. Novel treatments are being investigated for the treatment of DIC; many of these experimental modalities target the excessive TF activity that characterizes DIC.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Sophia Children’s Hospital, The Netherlands

    Jan A. Hazelzet & Ronald de Groot

  2. Erasmus Medical Center Rotterdam, The Netherlands

    Jan A. Hazelzet & Ronald de Groot

  3. Department of Immunopathology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Services, Amsterdam, The Netherlands

    C.Erik Hack

Authors
  1. Jan A. Hazelzet
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  2. C.Erik Hack
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  3. Ronald de Groot
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Editor information

Editors and Affiliations

  1. BC Research Institute for Children’s and Women’s Health, Vancouver, BC, Canada

    Andrew J. Pollard MD, PhD

  2. Wellcome Trust Centre for the Epidemiology of Infectious Disease, Oxford, UK

    Martin C. J. Maiden PhD

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© 2001 Humana Press Inc., Totowa, NJ

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Hazelzet, J.A., Hack, C., de Groot, R. (2001). Coagulation Studies. In: Walker, J.M., Pollard, A.J., Maiden, M.C.J. (eds) Meningococcal Disease. Methods in Molecular Medicine™, vol 67. Humana Press. https://doi.org/10.1385/1-59259-149-3:513

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  • DOI: https://doi.org/10.1385/1-59259-149-3:513

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-849-3

  • Online ISBN: 978-1-59259-149-7

  • eBook Packages: Springer Protocols

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