Abstract
The chemical mismatch cleavage (CMC) analysis was first described by Cotton et al. (1) and has successfully been used for detection and identification of mutations in several genes implicated in causing human genetic disorders (2-7). Compared with some current methods, such as denaturing gradient gel electrophoresis (8) and singlestranded conformation polymorphism (SSCP) which detects polymorphism in short DNA fragments, CMC has a higher diagnostic sensitivity and can analyze larger DNA fragment lengths (9).
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Ren, J. (2001). Chemical Mismatch Cleavage Analysis by Capillary Electrophoresis with Laser-Induced Fluorescence Detection. In: Mitchelson, K.R., Cheng, J. (eds) Capillary Electrophoresis of Nucleic Acids. Methods in Molecular Biology™, vol 163. Humana Press. https://doi.org/10.1385/1-59259-116-7:231
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DOI: https://doi.org/10.1385/1-59259-116-7:231
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