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Mutation Detection inTGF-β Receptors

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Part of the Methods in Molecular Medicine book series (MIMM, volume 50)

Abstract

The transforming growth factor β (TGF-β) receptors are an important class of tumor suppressor gene. TGF-β markedly inhibits the growth of many epithelial cell types; whereas in contrast, cancers of many different tissue types are commonly TGF-β resistant (10). Many cancer cell lines are resistant to the growth suppressive effects of TGF-β and display evidence of disruption of TGF-β signal transduction (10,4,10). To date, this resistance appears to often result from mutations in the TGF-β receptors or the smad family of TGF-β signaling proteins (5,11,12,14,16).

Keywords

Reaction Cocktail Template Length Premix Reaction 
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Copyright information

© Humana Press Inc. 2001

Authors and Affiliations

  1. 1.Ireland Cancer CenterUniversity Hospitals of ClevelandCleveland

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