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Vaccine Adjuvants pp 91–103Cite as

Poly(Lactide-Coglycolide) Microparticles As Vaccine Adjuvants

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Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 42))

Abstract

Over the last 20 years, the adjuvant effect achieved through the association of antigens with polymeric microparticles has been repeatedly demonstrated (1,2). Encapsulation of antigens into microparticles, including submicron particles (nanoparticles), promotes their entry into lymph nodes and provides a high local concentration of antigen over an extended time-period. Microparticles also promote the interaction of encapsulated antigens with antigen presenting cells (APCs), e.g., macrophages.

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Authors and Affiliations

  1. Chiron Corporation, Emeryville, CA

    Derek T. O’ Hagan & Manmohan Singh

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  1. Derek T. O’ Hagan
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  2. Manmohan Singh
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  1. Chiron Corporation, Emeryville, CA

    Derek T. O’Hagan

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© 2000 Humana Press Inc.

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O’ Hagan, D.T., Singh, M. (2000). Poly(Lactide-Coglycolide) Microparticles As Vaccine Adjuvants. In: O’Hagan, D.T. (eds) Vaccine Adjuvants. Methods in Molecular Medicine™, vol 42. Springer, Totowa, NJ. https://doi.org/10.1385/1-59259-083-7:91

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  • DOI: https://doi.org/10.1385/1-59259-083-7:91

  • Publisher Name: Springer, Totowa, NJ

  • Print ISBN: 978-0-89603-735-9

  • Online ISBN: 978-1-59259-083-4

  • eBook Packages: Springer Protocols

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