Abstract
Human skin is a complex system, providing a formidable obstacle to drug delivery Fig. 1 (1–3). In particular, the stratum corneum (SC) is the primary barrier to transdermal drug delivery. The stratum corneum is made up of corneocytes, which are flattened remnants of cells, surrounded by lipid bilayer membranes (2,3). Because lipid-based structures tend to exclude charged species, the multilamellar arrangement acts as a “brick wall” (4) to prevent ionic and molecular transport.
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Vaughan, T.E., Weaver, J.C. (2000). Mechanism of Transdermal Drug Delivery by Electroporation. In: Jaroszeski, M.J., Heller, R., Gilbert, R. (eds) Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery. Methods in Molecular Medicine, vol 37. Humana Press. https://doi.org/10.1385/1-59259-080-2:187
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