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Measurement of HAMA and Anti-Idiotypic Antibodies

  • Steve Nicholson
Part of the Methods in Molecular Medicine book series (MIMM, volume 40)

Abstract

Murine monoclonal antibodies (mAbs) when administered to patients are perceived much as any other foreign antigen: an immune response is usually mounted against them, the result of which is the generation of human antimouse antibodies (HAMA). Even in the absence of such immunization some patients may possess HAMA activity because of polyclonal IgM rheumatoid factors that crossreact with Fc epitopes on both human and mouse IgG (1).

Keywords

Wash Buffer Chromogenic Substrate Sodium Periodate Charing Cross Hospital Carboxymethyl Dextran 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press Inc. 2000

Authors and Affiliations

  • Steve Nicholson

There are no affiliations available

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