Abstract
Specific targeting of radioisotopes or toxic drugs to tumors for cancer detection and treatment is an enticing but elusive goal. It has proved difficult to achieve adequate concentration ratios between tumor and normal tissues to improve on standard diagnostic and therapeutic methods.
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References
Bierwaltes, W. H. (1982) The treatment of thyroid carcinoma with radioactive iodine. Semin. Nucl. Med. 23, 43.
Hofnagel, C. A. and Lewington, V. J. (1994) MIBG therapy, in Nuclear Medicine in Clinical Diagnosis and Treatment (Murray and Ell, eds.), Churchill Livingstone, Edinburgh, Scotland.
Bauer, F. K., Tubis, M., and Thomas, H. B. (1955) Accumulation of homologous radioiodinated albumin in experimental tumours. Proc. Soc. Exper. Biol. Med. 90, 140ā142.
Hoffer, P. P. and Gottschalk A. (1974) Tumour scanning agents. Semin. Nucl. Med. 4, 305ā316.
Quastel, M. R., Richter, A. M., and Levy, J. G. (1990) Tumour scanning with Indium-111 dihaematoporphyrin ether. Br. J. Cancer 62, 885ā890.
Zwi, L. J., Baguley, B. C., Gain, J. B., and Wilson, W. R. (1990) Necrosis in non-tumour tissues caused by flavone acetic acid and 5,6-dimethyl xanthenone acetic acid. Br. J. Cancer 62, 932ā934.
Nakajo, M., Kobayashi, H., Shimabukuro, K., Shirono, K., Sakata, H., Taguchi, M., Uchiyama, N., Sonoda, T., and Shinohara, S. (1988) Biodistribution of in vivo kinetics of Iodine-131 lipiodol infused via the hepatic artery of patients with hepatic cancer. J. Nucl. Med. 29, 1066ā1077.
Briele, B., Hotze, A., Oehr, P., Biersack, H. J., Rosanowski, F., Gorgulla, W., and Herberhold, C. (1990) Tumour imaging with labelled liposomes. Lancet 336, 875ā876.
Widder, K. J., Morris, R. M., Poore, G. A., Howard, D. P., and Senyei, A. E. (1983) Selective targeting of magnetic albumin microspheres containing low-dose doxorubicin: total remission in Yoshida sarcoma-bearing rats. Eur. J. Cancer Clin. Oncol. 19, 135ā139.
Evers, B. M., Parekh, D., Townsend, C. M., Jr., and Thompson, J. C. (1991) Somatostatin and analogues in the treatment of cancer. Ann. Surg. 213, 190ā198.
Mather, S. J. and Ward, B. G. (1987) High efficiency iodination of monoclonal antibodies for radiotherapy. J. Nucl. Med. 28, 1034ā1036.
Anderson, W. T., and Strand, M. (1978) Radiolabelled antibody: iodine versus radiometal chelates. NCI Monogr. 3, 149ā151.
Hillier, A. P. (1972) Deiodination of thyroid hormones by the perfused rat liver. J. Physiol. 222, 475ā485.
Pernis, B. (1985) Internalisation of lymphocyte membrane components. Immunol. Today 6, 45ā49.
Hnatowich, D. J., Virxi, F., and Doherty, P. W. (1985) DTPA-coupled antibodies labeled with yttrium-90. J. Nucl. Med. 26, 503ā509.
Stewart, J. S., Hird, V., Snook D., Sullivan, M., Myers, M. J., and Epenetos, A. A. (1988) Intraperitoneal 131I-and 90Y-labelled monoclonal antibodies for ovarian cancer: pharmacokinetics and normal tissue dosimetry. Int. J. Cancer (Suppl. 3), 71ā76.
Vriesendorp, H. M., Herpst, J. M., Leichner, P. K., Klein, J. L., and Order, S. E. (1989) Polyclonal 90Yttrium labeled antiferritin for refractory Hodgkinās disease. Int. J. Rad. Oncol. Biol. Phys. 17, 815ā821.
Rainsbury, R. and Westwood, J. (1982) Tumour localisation with monoclonal antibody radioactivity labelled with metal chelate rather than iodine. Lancet II: 1347ā1348.
Meares, C. F., Moi, M. K., Diril, H., Kukis, D. L., McCall, M. J., Deshpande, S. V., DeNardo, S. J., Snook, D., and Epenetos, A. A. (1990) Macrocyclic chelates of radiometals for diagnosis and therapy. Br. J. Cancer 62(Suppl. X), 21ā26.
Alvarez, V. L., Wen, M. L., Lee, C., Lopes, A. D., Rodwell, J. D., and McKearn, T. J. (1986) Site-specifically modified IIIIndium labeled antibodies give low liver backgrounds and improved radioimmunoscintigraphy. Int. J. Rad. Appl. Instrum. [B] 13, 347ā352.
Otsuka, F. L. and Fleishman, J. B. (1986) Comparative studies using 125I-and IIIInlabeled monoclonal antibodies. Eur. J. Nucl. Med. II, 295ā299.
Epenetos, A. A., Britton, K. E., Mather, S., Shepherd, J., Granowska, M., Taylor-Papadimitriou, J., Nimmon, C. C., Durbin, H., Hawkins, L. R., Malpas, J. S., and Bodmer, W. F. (1982) Targeting of Iodine-123-labelled tumour-associated monoclonal antibodies to ovarian, breast, and gastrointestinal tumours. Lancet II, 999ā1004.
Zamora, P. O., Bender, H., Knapp, F. F. (R.) Jr., and Biersack, H. J. (1996) Radiotherapy of intrathoracic carcinoma xenografts with 188Re-RC-160, a somatostatin analogue. Tumor Targeting 2, 49ā59.
Cole, W. C., DeNardo, S. J., Meares, C. F., McCall, M. J., DeNardo, G. L., Epstein, A. L., OāBrien, H. A., and Moi, M. K. (1987) Comparative serum stability of radiochelates for antibody radiopharmaceuticals. J. Nucl. Med. 28b 83ā90.
Schwarz, A., Streinstrasser, A., and Hoechst, A. G. (1987) A novel approach to Tc99m-labelled monodonal antibodies. J. Nucl. Med. 28, 721.
Baum, R. P., Hertel, A., Lorenz, M., Schwarz, A., Encke, A., and Hor, G. (1989) 99mTc-labelled anti-CEA monoclonal antibody for tumour immunoscintigraphy: first clinical results. Nucl. Med. Commun. 10, 345ā352.
Ott, R. J., Grey, L. J., Zivanovic, M. A., Flower, M. A., Trott, N. G., Moshakis, V., Coombes, R. C., Omerod, M. C., Westwood, J. H., and McCready, V. R. (1983) The limitations of the dual radionuclide subtraction technique for the external detection of tumour by radioiodine-labelled antibodies. Br. J. Radiol. 56, 101ā108.
Chandler, S. T. and Anderson, P. (1987) A method for thresholding subtracted images in radiolabelled-antibody imaging. Br. J. Radiol. 60, 881ā886.
Granowska, M., Nimmon, C. C., Britton, K. E., Crowther, M., Mather, S. J., Slevin, M. L., and Shepherd, J. H. (1988) Kinetic analysis and probability mapping applied to the detection of ovarian cancer by radioimmunoscintigraphy. J. Nucl. Med. 29, 599ā607.
Serafini, A. N., Goldenberg, D. M., Higinbotham-Ford, E. A., Silberstein, E. B., Van Heertum, R. L., Kotler, J. A., Balasubramanian, N., Garty, I., and Wlodkowski, T. (1989) A multicenter trial of cancer imaging with fragments of CEA monoclonal antibodies. J. Nucl. Med. 82, 748.
Goodwin, D., Meares, C., Diamanti, C., McCall, M., Lai, X., Torti, F., McTigue, M., and Martin, B. (1984) Use of specific antibody for rapid clearance of circulating blood background from radiolabelled tumour imaging proteins. Eur. J. Nucl. Med. 9, 209ā215.
Pedley, P. B., Dale, R., Boden, J. A., Begent, R. H., Keep, P. A., and Green, A. J. (1989) The effect of second antibody clearance on the distribution and dosimetry of radiolabelled anti-CEA antibody in a human colonic tumor xenograft model. Int. J. Cancer 43, 713ā718.
Wahl, R. L., Geatti, O., Liebert, M., Wilson, B., Shreve, P., and Beers, B. A. (1987) Kinetics of interstitially administered monoclonal antibodies for purposes of lymphoscintigraphy. J. Nucl. Med. 28, 1736ā1744.
Sutherland, R. M., Buchegger, F., Schreyer, M., Vacca, A., and Mach, J. P. (1987) Penetration and binding of radiolabeled anti-carcinoembryonic antigen monoclonal antibodies and their antigen binding fragments in human colon multicellu-lar spheroids. Cancer Res. 47, 1627ā1633.
Searle, F., Adam, T., and Boden, J. A. (1986) Distribution of intact and Fab2 fragments of anti-human chorionic gonadotrophin antibodies in nude mice bearing human choriocarcinoma xenografts. Cancer Immunol. Immunother. 21, 205ā208.
Burraggi, G. L., Callegaro, L., Marianari, G., Turrin, A., Cascinelli, N., Attili, A., Bombardieri, E., Terno, G., Plassio, G., Dovis, M, Mazzuca, N., Natali, P. G., Scassallati, G. A., Rosa, U., and Ferrone, S. (1985) Imaging with 131I-labelled monoclonal antibodies to a high molecular weight melanoma-associated antigen in patients with melanoma: efficiency of whole immunoglobulin and its F(ab)2 fragments. Cancer Res. 45, 3378ā3387.
Rowlinson-Busza, G., Deonarain, M. P., and Epenetos, A. A. (1996) Comparison of intact monoclonal antibody, its F(abā)2 and Fab fragments and recombinant single chain Fv in a human tumour xenograft model. Tumour Targeting 2, 37ā48.
Sharkey, R. M., Primus, F. J., Shochat, D., and Goldenberg, D. M. (1988) Comparison of tumour targeting of mouse monoclonal and goat polyclonal antibodies to carcinoembryonic antigen in the GW-39 human tumour-hamster host model. Cancer Res. 48, 1823ā1828
Goldenberg, D. M., Goldenberg, H., Sharkey, R. M., Lee, R. E., Higginbotham-Ford, E., Horowitz, J. A., Hall, T. C., Pinsky, C. M., and Hansen, H. J. (1989) Imaging of colorectal carcinoma with radiolabeled antibodies. Semin. Nucl. Med. 19, 262ā281.
Delgado, C., Pedley, B., Herraez, A., Boden, R., Boden, J. A., Keep, P. A., Chester, K. A., Fisher, D., Begent, R. H., and Francis, G. E. (1996) Enhanced tumour specificity of an anti-carcinoembryonic antigen Fabā fragment by poly(ethylene glycol) (PEG) modification. Br. J. Cancer 73, 175ā182.
Neri, D., de Lalla, C., Petrul, H., Soldani, P., di Stefano, A., Lozzi, L., Neri, G., and Neri, P. (1995) Engineering recombinant bifunctional antibodies. Tumour Targeting 1, 189ā194.
Green, N. M. (1963) Avidin. The nature of the biotin-binding site. Biochem. J. 89, 599ā609.
Hnatowich, D. J., Virzi, F., and Rusckowski, M. (1987) Investigations of avidin and biotin for imaging applications. J. Nucl. Med. 28, 1294ā1302.
Pimm, M. V., Fells, H. F., Perkins, A. C., and Baldwin, R. W. (1988) Iodine-131 and indium-111 labelled avidin and streptavidin for pre-targeted immuno-scintigraphy with biotinylated antitumour monoclonal antibody. Nucl. Med. Commun. 9, 931ā941.
Bagshawe, K. D., Sharma, S. K., Springer, C. J., and Antoniw, P. (1995) Antibody directed enzyme prodrug therapy: a pilot-scale clinical trial. Tumour Targeting 1, 17ā30.
Pimm, M. V. (1988) Drug-antibody conjugates for cancer therapy: potentials and limitations. Crit. Rev. Ther. Drug Carrier Syst. 5, 189ā227.
Weinstein, J. N., Steller, M. A., Keenan, A. M., Covell, D. G., Kay, M. E., Sieber, S. M., Oldham, R. K., Hwang, K. M., and Parker, R. J. (1983) Monoclonal antibodies in the lymphatics: selective delivery to lymph node metastases of a solid tumor. Science 222, 423ā426.
Epenetos, A. A., Courtenay-Luck N., Pickering, D., Hooker, G., Durbin, H., Lavender, J. P., and McKenzie, C. G. (1985) Antibody guided irradiation of brain glioma by arterial infusion of radioactive monoclonal antibody against epidermal growth factor receptor and blood group A antigen. Br. Med. J. 290, 1463ā1466.
Coakham, H. B., Richardson, R. B., Davies, A. G., Boume, A. P., Moseley, R. P., Kemshead, J. T., and Lashford, L. (1986) Antibody-guided radiation therapy via the CSF for malignant meningitis. Lancet II, 860,861.
Pectasides, D., Stewart, S., Courtenay-Luck N., Rampling, R., Munro, A. J., Krausz, T., Dhokia, B., Snook D., Hooker, G., Durbin, H., Taylor-Papadimitriou, J., Bodmer, W. F., and Epenetos, A. A. (1986) Antibody-guided irradiation of malignant pleural and pericardial effusions. Br. J. Cancer 53, 727ā732.
Hnatowich, D. J., Chinol, M., Siebecker, D. A., Gionet, M., Griffin, T., Doherty, P. W., Hunter, R., and Kase, K. R. (1988) Patient distribution of intraperitoneally administered yttrium-90-labeled antibody. J. Nucl. Med. 29, 1428ā1434.
Wahl, R. L., Barrett, J., Geatti, O., Liebert, M., Wilson, B. S., Fisher, S., and Wagner, J. G. (1988) The intraperitoneal delivery of radiolabeled monoclonal antibodies: studies on the regional delivery advantage. Cancer Immunol. Immunother. 26, 187ā201.
Smith, D. B., Mosely, R. P., Begent, R. H. J., Coakham, H. B., Glaser, M. G., Dewhurst, S., Kelly, A., and Bagshawe, K. D. (1990) Quantitative distribution of 131I-labelled monoclonal antibodies administered by the intraventricular route. Eur.J. Cancer 26, 129ā136.
Press, O. W., Eary, J. F., Badger, C. C., Martin, P. J., Appelbaum, F. R., Levy, R., Miller, R., Brown, S., Nelp, W. B., Krohn, K. A., Fisher, D., DeSantes, K., Porter, B., Kidd, P., Thomas, E. D., and Bernstein, I. D. (1989) Treatment of refractory non-Hodgkinās lym-phoma with radiolabeled MB-1 (anti-CD37) antibody. J. Clin. Oncol. 7, 1027ā1038.
Jain, R. K. and Baxter, L. T. (1988) Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumours: significance of raised interstitial pressure. Cancer Res. 48, 7022ā7032.
Maeda, H. (1991) SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy. Adv. Drug Delivery Rev. 6, 181ā202.
Braunschweiger, P. G. and Schiffer, L. M. (1986) Effect of dexamethasone on vascular function in RIF-1 tumors. Cancer Res. 46, 3299ā3303.
Leenders, K. L., Beaney, R. P., Brooks, D. J., Lammertsma, A. A., Heather, J. D., and McKenzie, C. G. (1985) Dexamethasone treatment of brain tumour patients: effects on regional cerebral blood flow, blood volume, and oxygen utilisation. Neurology 35, 1610ā1616.
Attard, A. R., Thomas, G. D., Chappell, M. J., Taylor, D. N., Baum, R. P., Dykes, P. W., Godfrey, K. R., Fraser, I. A., and Bradwell, A. R. (1991) Effect of high dose, high affinity antibody and dexamethasone on antibody uptake by colorectal cancer: results of a pilot study. Antibody, Immunoconj. Radiopharmaceut. 4, 871ā876.
Curti, B. D., Urba, W. J., Alvord, W. G., et al. (1993) Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment. Cancer Res. 53, 2204.
Schultz, K. R., Badger, C. C., Dombi, G. W., Greenberg, P. P., and Bernstein, I. D. (1992) Effect of interleukin-2 on biodistribution of monoclonal antibody in tumour and normal tissues in mice bearing SL-2 thymoma. J. Natl. Cancer Inst. 15, 109ā112.
Jones, P. T., Dear, P. H., Foote, J., Neuberger, M. S., and Winter, G. (1986) Replacing the complementarily-determining regions in a human antibody with those from a mouse. Nature 321, 522ā525.
Hamblin, T. J., Cattan, A. R., Glennie, M. J., Mackenzie, M. R., Stevenson, F. K., Watts, H. F., and Stevenson, G. T. (1987) Initial experience in treating human lymphoma with a chimeric univalent derivative of monoclonal anti-idiotype antibody. Blood 69, 790ā797.
McCabe, R. P., Peters, L. C., Haspel, M. V., Pomato, N., Carrasquillo, J. A., and Hanna, M. G., Jr. (1988) Preclinical studies on the pharmacokinetic properties of human monoclonal antibodies to colorectal cancer and their use for detection of tumors. Cancer Res. 48, 4348ā4353.
Ledermann, J. A., Begent, R. H. J., Bagshawe, K. D., Riggs, S. J., Searle, F., Glaser, M. G., Green, A. J., and Dale, R. G. (1988) Repeated antitumour antibody therapy in man with suppression of the host response by Cyclosporin A. Br. J. Cancer 58, 654ā657.
Zimma, A. M., Rosen, S. T., Spies, S. M., Golman-Leilin, R., Kazikiewicz, J. M., Silverstein, E. A., and Kaplan, E. H. (1988) Radioimmunotherapy of patients with cutaneous T-cell lymphoma using an iodine-131-labeled monoclonal antibody: analysis of retreatment following plasmapheresis. J. Nucl. Med. 19, 174ā180.
Rosenthal, K. C., Tompkins, W. A. F., and Rawls, W. E. (1980) Factors affecting the expression of carcinoembryonic antigen at the surface of cultured human colon carcinoma cells. Cancer Res. 40, 4774ā4750.
Iacobelli, S., Scambia, G., Natoli, C., Benedetti Panici, P., Baiocchi, G., Perone, L., and Mancuso, S. (1988) Recombinant human leucocyte interferon-Ī± 2b stimulates the synthesis and release of a 90K tumor-associated antigen in human breast cancer cells. Int. J. Cancer 42, 182ā184.
Rowlinson, G., Balkwill, F., Snook, D., Hooker, G., and Epenetos, A. A. (1986) Enhancement by gamma-interferon of in vivo tumour radiolocalization by a monoclonal antibody against HLA-DR antigen. Cancer Res. 46, 6413ā6417.
Wong, J. Y. C., Mivechi, N. F., Paxton, R. J., Williams, L. E., Beatty, B. G., Beatty, J. D., and Shively, J. E. (1989) The effects of hyperthermia on tumor carcinoembryonic antigen expression. Int. J. Radiol. Biol. Phys. 17, 803ā808.
Shi, Z. R., Tsao, D., and Kim, Y. S. (1983) Subcellular distribution, synthesis, and release of carcinoembryonic antigen in cultured human colon adenoma cell lines. Cancer Res. 43, 4045ā4049.
Goldenberg, D. M., Kim, E. E., DeLand, F. H., Spremulli, E., Nelson, M. O., Cockerman, J. P., Primus, F. J., Corgan, R. L., and Alpert, E. (1980) Clinical studies on the radioimmunodetection of tumours containing alpha-fetoprotein. Cancer 45, 2500ā2505.
Katoh, Y., Nakata, K., Kohno, K., Shima, M., Satoh, A., Kusumoto, Y., Ishii, N., Kohji, T., Shiku, H., and Nagataki, S. (1990) Immunoscintigraphy of human tumors transplanted in nude mice with radiolabeled anti-ras p21 monoclonal antibodies. J. Nucl. Med. 31, 1520ā1526.
Krizan, Z., Murray, J. L., Hersh, E. M., Rosenblum, M. G., Glenn, H. J., Gschwind, C. R., and Carlo, D. J. (1985) Increased labeling of human melanoma cells in vitro using combinations of monoclonal antibodies recognising separate cell surface antigenic determinants. Cancer Res. 45, 4904ā4909.
Baum, R. P, Lorenz, M., Hottenrott, C., Albrecht, M., Senekowitch, R., Happ, J., Hertel, A., Spitz, J., and Hor, G. (1988) Radioimmunoscintigraphy using monoclonal antibodies to CEA, CA 19-9 and CA 125. Int. J. Biol. Markers 3, 177ā184.
Durrant, L. G., Robins, R. A., and Baldwin, R. W. (1989) Flow cytometric screening of monoclonal antibodies for drug or toxin targeting to human cancer. J. Natl. Cancer Inst. 9, 688ā696.
Brown, M. S., Anderson, R. G. W., and Goldstein, J. L. (1983) Recycling receptors: the round-trip itinerary of migrant membrane proteins. Cell 32, 663ā667.
Glennie, M. J. and Stevenson, G. T. (1982) Univalent antibodies kill tumour cells in vitro and in vivo. Nature 295, 712ā714.
Nadler, L. M., Stashenko, P., Hardy, R., Kaplan, W. D., Burton, L. N., Kufe, D. W., Antman, K. H., and Schlossman, S. F. (1980) Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen. Cancer Res. 40, 3147ā3154.
Miller, R. A., Maloney, D. G., McKillop, J., and Levy, R. (1981) In vivo effects of murine hybridoma monoclonal antibody in a patient with T cell leukaemia. Blood 58, 78ā86.
Primus, F. J., Bennett, S. J., Kim, E. E., DeLand, F. H., Zahn, M. C., and Goldenberg, D. M. (1980) Circulating immune complexes in cancer patients receiving goat radiolocalising antibodies to carcinoembryonic antigen. Cancer Res. 40, 497ā501.
Bosslet, K., Steinstrasser, A., Schwarz, A., Harthus, H. P., Luben, G., Kuhlmann, L., and Sedlacek, H. H. (1988) Quantitative considerations supporting the irrelevance of circulating serum CEA for the immunoscintigraphic visualization of CEA expressing carcinomas. Eur. J. Nucl. Med. 14, 523ā528.
Stevenson, G. T., Glennie, M. J., Hamblin, T. J., Lane, A. C., and Stevenson, F. K. (1988) Problems and prospects in the use of lymphoma idiotypes as therapeutic targets. Int. J. Cancer Suppl. 3, 9ā12.
Mason, D. W. and Williams, A. F. (1980) The kinetics of antibody binding to membrane antigens in solution and at the cell surface. Biochem. J. 187, 1ā20.
Rostock, R. A., Klein, J. L., Kopher, K. A., and Order, S. E. (1984) Variables affecting the tumor localization of 131 I-anti-ferritin in experimental hepatoma. Am. Clin. Oncol. 6, 9ā18.
Eger, R. R., Covell, D. G., Carrasquillo, J. A., Abrams, P. G., Foon, K. A., Reynolds, J. C., Schroff, R. W., Morgan, A. C., Larson, S. M., and Weinstein, J. N. (1987) Kinetic model for the biodistribution of an 111Indium-labeled monoclonal antibody in humans. Cancer Res. 47, 3328ā3336.
Murray, J. L., Lamki, L. M., Shanken, L. J., Blake, M. E., Plager, C. E., Benjamin, R. S., Schweighardt, S., Unger, M. W., and Rosenblum, M. G. (1988) Immuno-specific saturable clearance mechanisms for Indium-111-labeled anti-melanoma monoclonal antibody 96. 5 in humans. Cancer Res. 48, 4417ā4422.
Carrasquillo, J. A., Abrams, P. G., Schroff, R. W., Reynolds, J. C., Woodhouse, C. S., Morgan, A. C., Keenan, A. M., Foon, K. A., Perentis, P., Marshall, S., Horowitz, M., Szymendera, J., Englert, J., Oldham, R. K., and Larson, S. M. (1988) Effect of antibody dose on the imaging and biodistribution of Indium-111 9.2.27 anti-melanoma monoclonal antibody. Nucl. Med. 29, 39ā17.
Chabot, G. G., Bissery, M.-C., Corbett, T. H., Rutkowski, K., and Baker, L. H. (1989) Pharmacodynamics and causes of dose-dependent pharmacokinetics of flavone-8-acetic acid (LM-975; NSC-347512) in mice. Cancer Chemother. Pharmacol. 24, 15ā22.
Chow, D. D., Essien, H. E., Padki, M. M., and Hwary, K. J. (1989) Targeting small unilamellar liposomes to hepatic parenchymal cells by dose effect. J. Pharmacol. Exp. Ther. 248, 506ā513.
Byers, V. S., Pimm, M. V., Pawluczyk, I. Z., Lee, H. M., Scannon, P. J., and Baldwin, R. W. (1987) Biodistribution of ricin-antibody conjugates and influence of hepatic blocking agents. Cancer Res. 47, 5277ā5283.
Covell, D. G., Barbet, J., Holton, O. D., Black, C. D. V., Parker, R. J., and Weinstein J. N. (1986) Pharmacokinetics of monoclonal immunoglobulin G1, F(abā)2, and Fabā in mice. Cancer Res. 46, 3969ā3978.
Oie, S. and Tozer, T. N. (1979) Effect of altered plasma protein binding on appar-ent volume of distribution. J. Pharm. Sci. 68, 1203ā1205.
Rowland, M. (1984) Physiologic pharmacokinetic models: relevance, experience and future trends. Drug Metab. Rev. 15, 55ā74.
DiStefano, J. J. and Chang, R. F. (1971) Computer simulation of thyroid hormone binding, distribution, and disposal dynamics in man. Am. J. Physiol. 221, 1529ā1544.
Ishikawa, H., Maeda, T., Hikita, H., and Miyatake, K. (1988) The computerised derivation of rate equations for enzyme reactions on the basis of the pseudo-steady-state assumption and the rapid-equilibrium assumption. Biochem. J. 251, 175ā181.
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Thomas, G.D. (2000). Practical Considerations in the Exploitation of Passive Tumor Targeting. In: Francis, G.E., Delgado, C. (eds) Drug Targeting. Methods in Molecular Medicineā¢, vol 25. Humana Press. https://doi.org/10.1385/1-59259-075-6:97
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