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Genetically Manipulated Models of Atherosclerosis in Mice

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Part of the Methods in Molecular Medicine™ book series (MIMM, volume 52)

Abstract

Mice are largely resistant to atherosclerosis. However, with dietary intervention or genetic manipulation, mice can be induced to develop atherosclerosis The focus of this chapter is genetically manipulated models (see Chapter 1 for discussion regarding diet-induced atherosclerosis). For a complex genetic disease like atherosclerosis, mouse models provide a suitable means for studying large numbers of animals and a means for manipulating genes thought to be important in lesion development. With the powerful genetic tool that gene-targeted mice provide, we are able to search for the pathogenesis of atherosclerosis, to assess the influence of risk factors, such as elevated plasma glucose or plasma fibrinogen levels, on disease progression. In addition, we can also test the effects of environment, hormones, and drugs on disease progression.

Keywords

Cocoa Butter Cholic Acid Fatty Streak Atherogenic Diet Standard Chow Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Humana Press Inc., Totowa, NJ 2001

Authors and Affiliations

  1. 1.Center for Cancer ResearchMassachusetts Institute of TechnologyCambridge

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